CD20 Over-Expression in Hodgkin-Reed-Sternberg Cells of Classical Hodgkin Lymphoma: the Neglected Quest

Benharroch, Daniel; Nalbandyan, Karen; Lazarev, I.A.

doi:10.7150/jca.13107

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…In fact, the prognostic relevance of BCA, p53, and Bcl2 in cHL is highly controversial. Literature data on BCA are focused mainly on CD20 and correlate its expression to either worse, 40 neutral, 41,42 or better 43 survival rates compared with controls. The same holds true for Bcl2 and p53, which have been variably associated with prognosis 10,20,43‐49 .…”

Section: Discussionmentioning

confidence: 99%

Histology of pediatric classic Hodgkin lymphoma: From diagnosis to prognostic stratification

Pizzi

Tazzoli

Carraro

et al. 2020

Pediatric Blood & Cancer

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Aims Classic Hodgkin lymphoma (cHL) is a common malignancy of the pediatric age. Although clinical‐radiological features are routinely used for disease risk stratification, the role of tumor histology has yet to be defined. This study aimed to characterize the clinical‐pathological features of a large cohort of pediatric cHL specifically investigating the relevance of tumor histology for the prognostic stratification of patients. Methods and results The study considered 96 clinically annotated cases of pediatric cHL treated according to the AIEOP‐LH2004 protocol. The following histological parameters were considered: (i) cHL variant; (ii) grade of nodular sclerosis (NS); (iii) staining for Bcl2 and p53, and expression of B‐cell (BCA) and T‐cell antigens (TCA) by Hodgkin/Reed‐Sternberg cells. The study population consisted of 51 males and 45 females (median age: 13.6 years) with five‐year overall and progression‐free survival of 94% and 81%, respectively. Most cases featured NS morphology (96%) with a prevalence of NS1 over NS2 grades. Two NS2 variants were recognized (sarcomatous/syncytial and fibrohistiocytic). A consistent subset of cases disclosed positivity for BCA (34%), TCA (26%), p53 (13%), and Bcl2 (19%). Clinical‐pathological correlations showed a more aggressive clinical course for NS2 over NS1 cases. The NS2 fibrohistiocytic variant was associated with the worst outcome. No other histological features correlated with prognosis. Conclusions Pediatric cHL is a clinically and histologically heterogeneous neoplasm. The majority of cases disclose NS morphology and aberrant phenotypes are frequently encountered. In the pediatric population, NS grading and NS2 subtyping bear significant prognostic impact.

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Section: Discussionmentioning

confidence: 99%

Histology of pediatric classic Hodgkin lymphoma: From diagnosis to prognostic stratification

Pizzi

Tazzoli

Carraro

et al. 2020

Pediatric Blood & Cancer

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“…In addition, older patients were reported to have a higher proportion of CD20-positivity than younger patients. 18 , 26 - 29 As our study found no significant correlation between CD79a and CD20 expression, they may be independent B-cell markers in CHL. Indeed, CD20- and CD79a-positivity were reported to be only weakly correlated.…”

Section: Discussionmentioning

confidence: 46%

“…In contrast to CD79a, the prognostic impact of CD20 has been well documented, although controversies remain. 26 , 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma

Sakatani

Igawa

Okatani

et al. 2020

JCEH

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Classic Hodgkin lymphoma (CHL) is a lymphoid neoplasia characterized by the presence of large tumor cells, referred to as Hodgkin and Reed-Sternberg (HRS) cells, originating from B-cells in an inflammatory background. As the clinical significance of B-cell markers has yet to be fully elucidated, this study aimed to clarify the clinicopathological significance of CD79a in 55 patients with CHL. They were immunohistochemically divided into two groups, comprising of 20 CD79a-positive and 35 CD79a-negative patients. There was no significant correlation between CD79a and CD20 expression ( r s = 0.125, P = 0.362). CD79a-positive patients were significantly older at onset ( P = 0.011). There was no significant correlation between CD79a-positivity and clinical stage ( P = 0.203), mediastinal involvement ( P = 0.399), extranodal involvement ( P = 0.749), or laboratory findings, including serum levels of lactate dehydrogenase ( P = 1) and soluble interleukin-2 receptor ( P = 0.251). There were significant differences in overall survival (OS) ( P = 0.005) and progression-free survival (PFS) ( P = 0.007) between CD79a-positive and CD79a-negative patients (5-year OS: 64.6% and 90.5%; 5-year PFS: 44.0% and 76.6%, respectively). Five patients in whom the majority (> 80%) of HRS cells expressed CD79a consisted of 4 males and 1 female aged between 52 and 81 years; 4 of them were in a limited clinical stage. We concluded that CD79a-positive CHL may have unique clinicopathological features.

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“…The clinical presentation, stage, clinical course, and response to therapy do not differ from conventional CD20-negative cases. 41,42 In equivocal cases, additional pan-B-cell markers (CD19, CD79a, BOB.1, and OCT-2), which are negative in CHL and positive in non-Hodgkin lymphomas, are necessary. Another source of potential confusion includes primary mediastinal B-cell lymphoma and nonmediastinal "gray-zone lymphoma," which in biopsy specimens demonstrate overlap between CHL and DLBCL, with foci resembling one or the other entity or with areas that show overlapping histologic features of both.…”

Section: Presence Of Rare Large Pleomorphic Cellsmentioning

confidence: 99%

Diagnosis of Lymphoid Lesions in Limited Samples

Mesa

Rawal

Gupta

2018

American Journal of Clinical Pathology

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CD20 Over-Expression in Hodgkin-Reed-Sternberg Cells of Classical Hodgkin Lymphoma: the Neglected Quest

Cited by 16 publications

References 20 publications

Histology of pediatric classic Hodgkin lymphoma: From diagnosis to prognostic stratification

Histology of pediatric classic Hodgkin lymphoma: From diagnosis to prognostic stratification

Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma

Diagnosis of Lymphoid Lesions in Limited Samples

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