CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia

Palumbo, Giuseppe A.; Parrinello, Nunziatina Laura; Fargione, Giovannella; Cardillo, Katia; Chiarenza, Annalisa; Berretta, Salvatore; Conticello, Concetta; Villari, Loredana; Raimondo, Francesco Di

doi:10.1016/j.leukres.2009.01.017

Cited by 122 publications

(121 citation statements)

References 37 publications

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“…8,9 In addition, CD200 immunoreactivity can be assessed by flow-cytometric analysis in addition to immunohistochemical staining (Palumbo et al 15 and Alapat et al 16 ; Pillai et al, manuscript in preparation). A number of B cell-derived neoplasms are immunoreactive for CD200, including chronic lymphocytic leukemia/ small lymphocytic lymphoma, hairy cell leukemia, B lymphoblastic leukemia/lymphoma, multiple myeloma, and classical Hodgkin lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…A number of B cell-derived neoplasms are immunoreactive for CD200, including chronic lymphocytic leukemia/ small lymphocytic lymphoma, hairy cell leukemia, B lymphoblastic leukemia/lymphoma, multiple myeloma, and classical Hodgkin lymphoma. 7,8 CD200 is useful in the differential diagnosis in a number of B cell-derived neoplasms, because it is not expressed in mantle cell lymphoma (vs chronic lymphocytic leukemia/small lymphocytic lymphoma), Burkitt lymphoma (vs B lymphoblastic leukemia/ lymphoma), or nodular lymphocyte predominant Hodgkin lymphoma (vs classical Hodgkin lymphoma; Dorfman and Shahsafaei 8 , Palumbo et al 15 ; Pillai et al, in preparation). In a recent flow-cytometric study, we found that CD200 staining can differentiate hairy cell leukemia from hairy cell leukemia variant as well (Pillai et al, in preparation).…”

Section: Discussionmentioning

confidence: 99%

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Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

2012

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CD200, an immunoglobulin superfamily membrane glycoprotein, is expressed in a number of B cell lymphoproliferative disorders, including primary mediastinal large B cell lymphoma, but not diffuse large B cell lymphoma, based on a preliminary study. Here, we compare the expression of CD200 with other markers of primary mediastinal large B cell lymphoma, including MAL and CD23, in formalin-fixed, paraffin-embedded histologic sections from a series of 35 cases of primary mediastinal large B cell lymphoma and 30 cases of diffuse large B cell lymphoma. CD200 exhibits the greatest staining sensitivity of the markers studied: 94%, compared with CD23 (69%), MAL (86%), TRAF (86%), and REL (77%). It exhibits staining specificity of 93%, similar to that of CD23 (93%) and MAL (97%), and greater than that of TRAF (77%) and REL (83%). We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

2012

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“…The inclusion of this marker in the routine investigation by flow cytometry is strongly recommended (20,21,22,23).…”

Section: Discussionmentioning

confidence: 99%

Atypical case of B-cell Chronic Lymphocytic Leukemia presenting with extreme hyperleukocytosis / Hiperleucocitoză extremă într-un caz atipic de leucemie limfatică cronică cu celulă B

Bacârea¹,

Bănescu²,

Macarie³

et al. 2014

Romanian Review of Laboratory Medicine

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“…79 CD200 and cyclin D1 may additionally help to discriminate B-CLL from mantle cell lymphoma in cases of B-NHL, although use of the latter marker in flow is still disputed. 80,81 CD123 is usually expressed on the HCL cells, which conversely may lack CD24. 69,82 CD138 and CD38 expression are appropriate to detect cells engaged in plasmacytoid differentiation, 75 and this is the recommended combination, together with CD45, to gate plasma cells.…”

Section: Additional Useful Markersmentioning

confidence: 99%

Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10

et al. 2011

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The European LeukemiaNet (ELN), workpackage 10 (WP10) was designed to deal with diagnosis matters using morphology and immunophenotyping. This group aimed at establishing a consensus on the required reagents for proper immunophenotyping of acute leukemia and lymphoproliferative disorders. Animated discussions within WP10, together with the application of the Delphi method of proposals circulation, quickly led to post-consensual immunophenotyping panels for disorders on the ELN website. In this report, we established a comprehensive description of these panels, both mandatory and complementary, for both types of clinical conditions. The reason for using each marker, sustained by relevant literature information, is provided in detail. With the constant development of immunophenotyping techniques in flow cytometry and related software, this work aims at providing useful guidelines to perform the most pertinent exploration at diagnosis and for follow-up, with the best cost benefit in diseases, the treatment of which has a strong impact on health systems.

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CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia

Cited by 122 publications

References 37 publications

Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

Atypical case of B-cell Chronic Lymphocytic Leukemia presenting with extreme hyperleukocytosis / Hiperleucocitoză extremă într-un caz atipic de leucemie limfatică cronică cu celulă B

Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10

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