CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity

Modak, Madhura; Mattes, Ann-Kathrin; Reiss, Daniela; Skrońska-Wąsek, Wioletta; Langlois, Rebecca; Sabarth, Nicolas; Konopitzky, Renate; Ramírez, Fidel; Lehr, Katharina; Mayr, Tobias; Kind, David; Viollet, Coralie; Swee, Lee Kim; Petschenka, Jutta; Kasmi, Karim C. El; Noeßner, Elfriede; Kitt, Kerstin; Pflanz, Stefan

doi:10.1172/jci.insight.155022

Cited by 54 publications

(33 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, a recent study highlighted the importance of CD206 + macrophages as integral part of the anti-tumor orchestra. Similar to Clec9a+ cross-presenting dendritic cells, F4/80highCD206 + macrophages were shown to be important for the activation of anti-tumoral T cells by cross-presenting tumor antigens [96].…”

Section: Cellular Immunosuppression In the Melanoma Microenvironmentmentioning

confidence: 97%

Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges

Indini¹,

Massi²,

Pirro³

et al. 2022

Seminars in Cancer Biology

View full text Add to dashboard Cite

Section: Cellular Immunosuppression In the Melanoma Microenvironmentmentioning

confidence: 97%

Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges

Indini¹,

Massi²,

Pirro³

et al. 2022

Seminars in Cancer Biology

View full text Add to dashboard Cite

“…(Allavena et al, 2010;van der Zande et al, 2021) Contrarily, in models of melanoma and colon cancer high CD206 expression on TAMs was associated with improved cross presentation of tumor neoantigens to CD8 + T cells resulting in better tumor control. (Modak et al, 2022) The expression of the scavenger receptor CD163 is restricted to macrophages and to a lesser extend monocytes and closely linked to an anti-inflammatory phenotype. (Skytthe et al, 2020) CD163 binds haptoglobin-hemoglobin complexes and removes toxic free hemoglobin and damaged erythrocytes from the circulation thereby stimulating the production of anti-inflammatory hememetabolites.…”

Section: Phagocytosis and Scavenging-the Role Of Antiinflammatory Mar...mentioning

confidence: 99%

The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities

Kohlhepp

Liu

Tacke

et al. 2023

Front. Mol. Biosci.

View full text Add to dashboard Cite

Chronic liver diseases from varying etiologies generally lead to liver fibrosis and cirrhosis. Among them, non-alcoholic fatty liver disease (NAFLD) affects roughly one-quarter of the world population, thus representing a major and increasing public health burden. Chronic hepatocyte injury, inflammation (non-alcoholic steatohepatitis, NASH) and liver fibrosis are recognized soils for primary liver cancer, particularly hepatocellular carcinoma (HCC), being the third most common cause for cancer-related deaths worldwide. Despite recent advances in liver disease understanding, therapeutic options on pre-malignant and malignant stages remain limited. Thus, there is an urgent need to identify targetable liver disease-driving mechanisms for the development of novel therapeutics. Monocytes and macrophages comprise a central, yet versatile component of the inflammatory response, fueling chronic liver disease initiation and progression. Recent proteomic and transcriptomic studies performed at singular cell levels revealed a previously overlooked diversity of macrophage subpopulations and functions. Indeed, liver macrophages that encompass liver resident macrophages (also named Kupffer cells) and monocyte-derived macrophages, can acquire a variety of phenotypes depending on microenvironmental cues, and thus exert manifold and sometimes contradictory functions. Those functions range from modulating and exacerbating tissue inflammation to promoting and exaggerating tissue repair mechanisms (i.e., parenchymal regeneration, cancer cell proliferation, angiogenesis, fibrosis). Due to these central functions, liver macrophages represent an attractive target for the treatment of liver diseases. In this review, we discuss the multifaceted and contrary roles of macrophages in chronic liver diseases, with a particular focus on NAFLD/NASH and HCC. Moreover, we discuss potential therapeutic approaches targeting liver macrophages.

show abstract

“…LRP6 and MARK2P16 belong to the WNT pathway required for leukemia stem cells development (Wang et al, 2010). Finally, CLEC9A is a lectin specifically expressed in immune cell subsets of the tumor microenvironment (Modak et al, 2022). Additionally, the genes found have different behaviors in AML and cohorts from healthy donors, showing specific deregulation in AML regardless of the NPM1 mutation condition.…”

Section: Appmentioning

confidence: 99%

A k-mer based transcriptomics analysis for NPM1-mutated AML

Silva

Riedel

Guibert

et al. 2023

Preprint

View full text Add to dashboard Cite

Motivation: Acute Myeloid Leukemia is a highly heterogeneous disease. Although current classifications are well-known and widely adopted, many patients experience drug resistance and disease relapse. New biomarkers are needed to make classifications more reliable and propose personalized treatment. Results: We performed tests on a large scale in 3 AML cohorts, 1112 RNAseq samples. The accuracy to distinguish NPM1 mutant and non-mutant patients using machine learning models achieved more than 95% in three different scenarios. Using our approach, we found already described genes associated with NPM1 mutations and new genes to be investigated. Furthermore, we provide a new view to search for signatures/biomarkers and explore diagnosis/prognosis, at the k-mer level. Availability: Code available at https://github.com/railorena/npm1aml and https://osf.io/4s9tc/. The cohorts used in this article were authorized for use.

show abstract

CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity

Cited by 54 publications

References 55 publications

Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges

Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges

The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities

A k-mer based transcriptomics analysis for NPM1-mutated AML

Contact Info

Product

Resources

About