CD209 (DC-SIGN) −336A&gt;G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese

Chan, Kelvin Y.K.; Xu, Meishu; Ching, Johannes C.Y.; So, Thomas; Lai, Sik To; Chu, Chung Ming; Yam, Loretta Yin‐Chun; Wong, Andrew T.Y.; Chung, Pui Hong; Chan, Vivien; Chen, Lin; Sham, Pak C.; Leung, Gabriel M.; Peiris, Malik; Khoo, Ui‐Soon

doi:10.1016/j.humimm.2010.03.006

Cited by 37 publications

(42 citation statements)

References 42 publications

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“…Based on this hypothesis, we examined the influence of five single nucleotide polymorphisms (SNPs) in the promoter region of DC-SIGN that have been reported to a) influence the promoter activity and b) are associated with several infectious diseases [13,14,[17][18][19][20][21][22], with IVIG response among KD patients of three ethnic groups -Whites, Asians and Hispanics. KD patients who were treated with IVIG and had documented response data from our ongoing cohort recruited from Seattle Children's Hospital, Oakland Children's Hospital, and Primary Children's Hospital of Utah were included in this study.…”

Section: Resultsmentioning

confidence: 99%

DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease

et al. 2013

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BackgroundGenetic variants in the inhibiting FcγRIIB mediate anti-inflammatory responses and influence IVIG refractoriness (IVIG-R). However, these variants are rare in Asian and Hispanic populations so other genes in the pathway could be potentially involved. IVIG is ineffective in mice lacking SIGN-R1, a related molecule to human DC-SIGN. Further, DC-SIGN is a known receptor for sialylated Fc, the component responsible for the anti-inflammatory action of IVIG. Thus, we hypothesized that DC-SIGN would also be involved in the pathway of IVIG response in Kawasaki Disease (KD) patients.FindingsA case-control approach was performed to examine the differential distribution of five single nucleotide polymorphisms (SNPs) in DC-SIGN promoter with IVIG-R among White (158 vs. 62), Asian (64 vs. 12) and Hispanic (55 vs. 20) KD patients. Distinct differences in allele frequency distributions of several variants in the DC-SIGN promoter were observed in the three ethnic groups. Further, Asians with the major allele “A” in rs2287886 were more likely (OR = 1.76, p = 0.04) to be IVIG non-responder, but this allele is a minor allele in other two ethnic groups, where the association was not apparent.ConclusionsDC-SIGN can potentially complement the role of FcγRIIB in the anti-inflammatory cascade involved in the IVIG response mechanism.

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Section: Resultsmentioning

confidence: 99%

DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease

et al. 2013

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“…For example, SNPs of genes involved in innate immunity were correlated with SARS-CoV load during the initial phase of infection [49]. A 336A > G promoter polymorphism in the gene encoding CD209 (DC-SIGN) was correlated with clinical-pathologic outcomes in 824 serologically confirmed SARS patients [50]. The -336AG/GG genotype was associated with lower standardized lactatedehydrogenase (LDH) levels compared with the '-336AA' genotype carrying patients with a 60% chance of having a poorer prognosis because of higher LDH levels.…”

Section: Discussionmentioning

confidence: 99%

Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

Brunn

Ciesek

Brunn

et al. 2015

Current Opinion in Virology

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Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of several viruses. Here, we summarize present knowledge on the role of cyclophilin A during coronavirus replication. We present data on the effect of cyclophilin A single nucleotide polymorphism mutants on the replication of human CoV-229E demonstrating the requirement of proper cyclophilin A function for virus propagation. Results define cellular cyclophilin A as a host target for inhibition of coronaviruses ranging from relatively mild common cold to highly pathogenic SARS-CoV and MERS-CoV viruses with the perspective of disclosing non-immunosuppressive cyclosporin A analogs to broadly inactivate the coronavirus family.

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“…Moreover, M tuberculosis Manose-dependent binding to CD209 leads to Raf-1-dependent upregulation of IL-6 [15]. However, the DC-SIGN -336G variant affects a Sp1 binding site and decreases the expression of DC-SIGN resulting in less efficient cytokine and chemokine secretion [8,30]. It is hypothesized that individuals homozygous for the -336G allele may, in part, be protected from expressing low levels of DC-SIGN and therefore less prone to the IL-6 secretion induced by Manose-dependent binding to DC-SIGN.…”

Section: Discussionmentioning

confidence: 99%

Relationship between polymorphism of DC-SIGN (CD209) gene and the susceptibility to pulmonary tuberculosis in an eastern Chinese population

et al. 2011

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Dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is an important receptor for Mycobacterium tuberculosis on human dendritic cells. Previous studies have shown that the variation, especially the -871A/G and -336A/G in DC-SIGN promoter influenced the susceptibility to tuberculosis. We therefore investigated whether polymorphisms in the DC-SIGN gene were associated with susceptibility to tuberculosis in an eastern Chinese population. A total of 237 culture-positive pulmonary tuberculosis case patients and 244 controls were genotyped for -871A/G and -336A/G by pyrosequencing. Our results suggested that the 2 promoter variants of DC-SIGN gene were not associated with susceptibility to tuberculosis in Chinese. Further analysis showed that the allele -336G was associated with a protective effect against fever in pulmonary tuberculosis patients, but not against cavity formation. In addition, we compared the allelic frequencies of -871A/G and -336A/G in African, Caucasian, and Asian groups. The results showed that the tw forms of allelic frequencies detected Chinese individuals in our study were similar to the reported frequencies in other Asian populations but differed significantly from those in the African and Caucasian groups studied.

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CD209 (DC-SIGN) −336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese

Cited by 37 publications

References 42 publications

DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease

DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease

Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

Relationship between polymorphism of DC-SIGN (CD209) gene and the susceptibility to pulmonary tuberculosis in an eastern Chinese population

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