Cd23

Barclay, A. Neil; Brown, Marion H.; Law, S.K. Alex; McKnight, Andrew J.; Tomlinson, Michael G.; Merwe, P. Anton van der

doi:10.1016/b978-012078185-0/50458-3

Cited by 1 publication

(2 citation statements)

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“…The expression of the IL‐2 receptor α‐chain (CD25) on CD19 + B cells was unchanged in patients with thalassaemia major compared with the reference group (Fig 2). CD23, the IgE Fc receptor is up‐regulated following B‐cell activation, CD40 ligation or in response to certain T‐helper‐2‐type cytokines (Barclay et al , 1997). The percentage and absolute numbers of CD23 + B cells was significantly raised ( P < 0.05 and P = 0.01 respectively, Mann‐Whitney) in these patients (Fig 2).…”

Section: Resultsmentioning

confidence: 99%

“…These patients revealed raised expression of CD23, a low‐affinity receptor for IgE which is up‐regulated with B‐cell activation. Many functions have been ascribed to CD23 and one of these is regulation of IgE production (Barclay et al , 1997). There was a correlation between raised IgE production and CD23 expression on B lymphocytes in these patients.…”

Section: Discussionmentioning

confidence: 99%

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Functional lymphocyte immunophenotypes observed in thalassaemia and haemophilia patients receiving current blood product preparations

Hodge

Lloyd²,

Hodge

et al. 1999

Br J Haematol

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Summary.Immune abnormalities have been reported in recipients of cellular and plasma blood products. To document the effect of current transfusion practices, we performed ex vivo lymphocyte immunophenotypic studies on patients with thalassaemia major who had received multiple (leucocyte-depleted) transfusions and patients with haemophilia A and B who had received heat viral-inactivated factor concentrates. Patients with thalassaemia major showed a significant lymphocytosis, with mainly B-cell changes consistent with ongoing B-cell stimulation associated with chronic exposure to red cell antigens. Reduced T-cell IL-2Ra expression would be consistent with inhibition by desferrioxamine chelation therapy. In contrast, patients with haemophilia showed predominantly T-cell changes. Patients with haemophilia A showed significantly elevated activated CD8 þ cytotoxic T lymphocytes whereas those with haemophilia B showed an increase in CD8þ CD11a dim and CD4suppressor T cells. Several of the immune abnormalities found may be due to the presence of cytokines not removed by leucocyte filtration or destroyed by factor concentrate production (e.g. TGF-b) causing a T-helper-2-like response. The extensive lymphocyte characterization in this study has not previously been performed and has enabled a closer examination of the functional lymphocyte immunophenotypes seen in patients treated according to current transfusion practices.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%