CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection #

Li, Dongling; Zheng, Linghua; Jin, Lei; Zhou, Yue-Su; Li, Haiying; Fu, Junliang; Shi, Ming; Du, Pu; Wang, Lizhong; Wu, Hao; Chen, Guoyun; Zheng, Pan; Liu, Yang; Wang, Fu Sheng; Wang, Shengdian

doi:10.1002/hep.23047

Cited by 41 publications

(49 citation statements)

References 37 publications

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“…92 Importantly, targeted mutation of CD24 significantly reduced the size of hepatocellular carcinomas induced by the transgenic expression of hepatitis virus B genes. 104 However, additional studies are needed to demonstrate the function of CD24 in cancer pathogenesis and the underlying mechanisms involved. …”

Section: Cd24 In Cancer Cellsmentioning

confidence: 99%

CD24: from A to Z

et al. 2010

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As a testament to the importance of CD24, researchers with diverse interests, including adaptive immunity, inflammation, autoimmune diseases and cancer, have encountered CD24. CD24 is overexpressed in many cancers and appears oncogenic. In the adaptive immune response, CD24 is a redundant costimulatory molecule in costimulation-rich lymphoid organs but is essential in selected target organs tested, such as brain and skin. More recent studies suggest it may have a role in discriminating danger and pathogen-associated molecular patterns by dendritic cells. The biology of CD24 is intriguing but poorly understood. Here we summarize the major findings associated with CD24 to stimulate new ideas for further research that may reveal the underlying link among the diverse processes mediated by CD24.

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Section: Cd24 In Cancer Cellsmentioning

confidence: 99%

CD24: from A to Z

et al. 2010

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“…It was a striking evidence indicating that T cells had played a critical role in Concanavalin A-induced liver injury (Figures 2A-2F) [12,13]. So we show the change of T cells by calculating the percentage of CD4+ and CD8+ cells in the liver which used the flow cytometry ( Figures 3A and 3B) [14][15][16].…”

Section: The Difference Of Cd4+ and Cd8+mentioning

confidence: 99%

The Comparison between HBV Transgenic Mice and Normal Mice after Being Injected Concanavalin A (Con A)

Cheng¹,

Liu²,

Mu³

et al. 2017

Pharm Anal Chem

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HBV transgenic mice are used as chronic hepatitis B models for research, but they cannot be infected by HBV to have the hepatitis B as the same as human. In the research, we explored the differences between HBV transgenic mice and normal mice who are injected the concanavalin, A which can injure the livers of the mice. We found some data to show the differences of them after the injection, such as weight, pictures of the liver tissue, alanine transaminase (ALT) and aspartate transaminase (AST) in the blood. The pro-inflammatory cytokines (IL-6, IFN-γ and TNF-α) and T cells (CD4+ cells and CD8+ cells) also showed the livers of HBV transgenic mice were more vulnerable to be hurt than normal mice.

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“…Furthermore, CD24, initially discovered as a lymphoid differentiation marker, is expressed on activated T cells, B cells, macrophages, and dendritic cells [22]. One of the biologic functions reported for CD24 is a costimulatory activity for the clonal expansion of T cells [23,24].…”

Section: Introductionmentioning

confidence: 99%

“…The first one, a C [ T single-nucleotide polymorphism (SNP; rs52812045 at position 170 from the CD24 translation start site), is located in the putative GPI-anchor cleavage site (-1 position), whereby a valine (V) substitutes an alanine (A). The P170T/T (CD24 V/V) genotype is associated with an increased risk and more rapid progression of MS, SLE, giant cell arteritis, and chronic hepatitis B [22,29,30,[32][33][34], whereas the second polymorphism, a dinucleotide deletion (TG/Del) within the 3 0 UTR (rs3838646), highly reduces CD24 mRNA stability and is strongly protective [22,29,30,[32][33][34]. These consistent data suggest that CD24 plays an important role in modulating immune response and autoimmunity.…”

Section: Introductionmentioning

confidence: 99%

“…Two polymorphisms within the CD24 gene were shown to modify disease risk and progression in multiple sclerosis (MS), systemic lupus erythematosus (SLE), giant cell arteritis, and, most recently, chronic hepatitis B too [22,[28][29][30][31][32][33]. The first one, a C [ T single-nucleotide polymorphism (SNP; rs52812045 at position 170 from the CD24 translation start site), is located in the putative GPI-anchor cleavage site (-1 position), whereby a valine (V) substitutes an alanine (A).…”

Section: Introductionmentioning

confidence: 99%

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CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer

Marmé

Werft

Walter

et al. 2011

Breast Cancer Res Treat

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Overexpression of CD24 is an independent prognostic factor for breast cancer. Recently, two polymorphisms in the CD24 gene were linked to disease risk and progression in autoimmune diseases. Here, we evaluated the clinical relevance of these polymorphisms with respect to their potential to predict a pathologic complete response (pCR) to neoadjuvant chemotherapy (NCT) for primary breast cancer (PBC), one of the strongest prognostic factors in this setting. A total of 257 patients were randomized to either doxorubicin/cyclophosphamide (AC) or doxorubicin/pemetrexed (AP), both followed by docetaxel (Doc) as NCT for T2-4 N0-2 M0 PBC as part of an international, multicenter, randomized phase II trial. CD24 polymorphisms were analyzed on germ line DNA and correlated with clinicopathologic variables and pCR. No significant associations were found between either of the polymorphisms and any of the clinicopathologic variables. In a multivariate analysis, CD24 Val/Val genotype was the only significant predictor of pCR (OR: 4.97; P = 0.003). The predictive potential was significant in both treatment arms and in the hormone receptor-positive subgroup. There was no correlation between CD24 3'UTR (TG/Del) genotype and pCR. We did not observe any association between CD24 genotype and CD24 protein expression or in vitro chemosensitivity, but there was a significant correlation between CD24 Val/Val and intratumoral lymphocyte aggregates. In conclusion, CD24 Ala/Val SNP is a strong and independent predictor of pCR after NCT for PBC and may affect immune functions rather than tumor characteristics. Further evaluation of the CD24 function and validation of its predictive potential are clearly warranted.

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CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection #

Abstract: T-cell immunity to hepatitis B virus (HBV) is involved in both viral

Cited by 41 publications

References 37 publications

CD24: from A to Z

CD24: from A to Z

The Comparison between HBV Transgenic Mice and Normal Mice after Being Injected Concanavalin A (Con A)

CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer

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