CD26/dipeptidyl‐peptidase IV and adenosine deaminase serum levels in psoriatic patients treated with cyclosporine, etanercept, and psoralen plus ultraviolet A phototherapy

Yıldırım, Fatma Elif; Karaduman, Ayşen; Pınar, Aslı; Aksoy, Yasemin

doi:10.1111/j.1365-4632.2010.04799.x

Cited by 11 publications

(13 citation statements)

References 32 publications

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“…These findings support the hypothesis that adenosine deaminase could be validated by further studies as a useful indicator in monitoring patients with psoriasis, assessing the response to therapy and predicting the prognosis of the disease (52,54,55). In previous studies on patients with psoriasis, adenosine deaminase activity was found to decline after treatment with PUVA, cyclosporine, etanercept, and psoralen, reconfirming the ability of this enzyme to be associated with T-cell activation (55,56). The increase in adenosine deaminase activity could become a predictive factor for identifying patients with psoriasis at risk of developing relapses prior to the occurrence of clinical manifestations.…”

Section: Psoriasis Vulgaris Pasi Score ------------------------------supporting

confidence: 71%

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=-0.301 and P= 0.036, r=-0.384 and P= 0.002). Thus, severe psoriasis is a risk factor for the development of renal disease.

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Section: Psoriasis Vulgaris Pasi Score ------------------------------supporting

confidence: 71%

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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“…Its mRNA, protein levels and activity are higher in psoriatic skin samples ( 245 , 246 ). By contrast, serum DPPIV levels and activity seem to be lower in patients ( 247 , 248 ), accompanied by a reduction of peripheral CD8 + CD26 + T cells ( 249 , 250 ). Two case reports suggest a link between the use of DPPIV inhibitor sitagliptin and psoriasis.…”

Section: The Dpp Family In Inflammatory Diseasementioning

confidence: 89%

The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis

et al. 2015

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Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its family members in many processes and different pathologies of the immune system. Most research has been focused on either DPPIV or just a few of its family members. It is, however, essential to consider the entire DPP family when discussing any one of its members. There is a substantial overlap between family members in their substrate specificity, inhibitors, and functions. In this review, we provide a comprehensive discussion on the role of prolyl-specific peptidases DPPIV, FAP, DPP8, DPP9, dipeptidyl peptidase II, prolyl carboxypeptidase, and prolyl oligopeptidase in the immune system and its diseases. We highlight possible therapeutic targets for the prevention and treatment of atherosclerosis, a condition that lies at the frontier between inflammation and cardiovascular disease.

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“…Many studies have also reported a decrease of serum ADA levels after psoriasis treatment with different modalities including cyclosporine, etanercept, PUVA, and PTU. 10,22 On the contrary, one study found normal ADA activity in psoriatic patients. 23 This could be due to the few number of patients (only 18) and the use of a normal laboratory range instead of a control group in that study.…”

Section: Discussionmentioning

confidence: 95%

“…Some studies report high ADA in the sera of psoriatic patients than that of the healthy controls. 21,22 Tikhonov et al 9 , found double activities of ADA and purine nucleoside phosphorylase (PNP) in the skin of psoriatic patients. In accordance with our results Hashemi et al 21 and Yildirum et al 22 found no correlation between serum ADA and PASI score.…”

Section: Discussionmentioning

confidence: 99%

“…21,22 Tikhonov et al 9 , found double activities of ADA and purine nucleoside phosphorylase (PNP) in the skin of psoriatic patients. In accordance with our results Hashemi et al 21 and Yildirum et al 22 found no correlation between serum ADA and PASI score. Many studies have also reported a decrease of serum ADA levels after psoriasis treatment with different modalities including cyclosporine, etanercept, PUVA, and PTU.…”

Section: Discussionmentioning

confidence: 99%

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Hyperuricemia and Serum ADA Levels in Psoriasis and their Correlation to Severity of Disease

Nadeem¹,

Shah²,

Waseem³

et al. 2019

IJCMR

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Introduction: Psoriasis is a chronic inflammatory autoimmune disease characterized by hyperproliferation of keratinocytes with multifactorial pathogenesis including genetic, and environmental factors. The aim of this study was to evaluate serum ADA, SUA, and ESR in psoriatic patients and their correlations with PASI score. Material and methods: Our study was a case-control study. The sample size was calculated using the Cochran formula and 50 patients of psoriasis who attended the out patient clinic at SMHS and Government medical college, srinagar were included in the study. These patients were divided according to PASI scores into three groups (mild, moderate, and severe). PASI score <10 defined psoriasis as mild, between 10 and 20 as moderate, and >20 as severe. A group of 50 healthy subjects of matched age and sex were included as a control group who were taken from amongst volunteering hospital staff and relatives. Results: This study included 50 psoriatic patients classified according to PASI score into mild, moderate, and severe psoriatic group and 50 age and sex matched controls. Out of these four patients had mild psoriasis, twelve patients had moderate psoriasis and thirty four patients had severe psoriasis according to PASI. Fifty healthy subjects were included as a control group. There were no statistically significant differences of age and sex between different patients and the control group. Conclusion: ESR, Serum Uric Acid and serum adenosine deaminase levels are significantly raised in patients with psoriasis. However there was no association with severity of disease in these patients, however, larger studies are needed to elucidate the mechanism and whether this hyperuricemia predisposes these patients to gout and increased risk of cardiovascular disease.

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CD26/dipeptidyl‐peptidase IV and adenosine deaminase serum levels in psoriatic patients treated with cyclosporine, etanercept, and psoralen plus ultraviolet A phototherapy

Cited by 11 publications

References 32 publications

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis

Hyperuricemia and Serum ADA Levels in Psoriasis and their Correlation to Severity of Disease

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