2016
DOI: 10.1016/j.bbrc.2016.08.115
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CD27 - CD45 + γδ T cells can be divided into two populations, CD27 - CD45 int and CD27 - CD45 hi with little proliferation potential

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Cited by 21 publications
(13 citation statements)
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“…Despite the current model stating that terminally differentiated γδ T lymphocytes have progressively lost their proliferative capacity (13)(14)(15), the third conclusion of this study is that some terminally differentiated TEMRA cells from both TCRVδ1 and TCRVδ2 subsets of γδ T lymphocytes have kept a significant proliferative capacity. This proliferative capacity remains in a CD45RA intermediate subpopulation of TEMRA cells, however, fully consistent with a recent report depicting two populations of TEMRA TCRVδ2 cells in solid cancer patients (55). This unattended finding arose from the unbiased algorithmic spotting of mitotic gene signatures in cells positioned at the end of chronologically ordered maturation trajectories, and was validated by further flow cytometric analyses and in vitro proliferation assays.…”
Section: Discussionsupporting
confidence: 90%
“…Despite the current model stating that terminally differentiated γδ T lymphocytes have progressively lost their proliferative capacity (13)(14)(15), the third conclusion of this study is that some terminally differentiated TEMRA cells from both TCRVδ1 and TCRVδ2 subsets of γδ T lymphocytes have kept a significant proliferative capacity. This proliferative capacity remains in a CD45RA intermediate subpopulation of TEMRA cells, however, fully consistent with a recent report depicting two populations of TEMRA TCRVδ2 cells in solid cancer patients (55). This unattended finding arose from the unbiased algorithmic spotting of mitotic gene signatures in cells positioned at the end of chronologically ordered maturation trajectories, and was validated by further flow cytometric analyses and in vitro proliferation assays.…”
Section: Discussionsupporting
confidence: 90%
“…Factors associated with adequate Vγ9Vδ2 T-cell proliferation were investigated in 67 patients; one 72-year-old patient with good Vγ9Vδ2 T-cell proliferation was nonetheless excluded because of a lack of information about prior therapy (online supplemental table S2). As reported previously, 23 the numbers and phenotypes of Vγ9Vδ2 T-cells in PBMC are the most important factors predicting successful Vγ9Vδ2T-cell cultures (p=0.0000565). Sex, the total number of prior therapies, history of surgery or radiation, or type of earlier regimen was not associated with the outcome of Vγ9Vδ2 T-cell culturing.…”
Section: Small-scale Vγ9vδ2 T-cell Culture Screening Testssupporting
confidence: 66%
“…Using zoledronate and IL-2, we cultured autologous Vγ9Vδ2 T-cells from patients with advanced cancer under clinical-grade conditions. 19–22 Unfortunately, Vγ9Vδ2 T-cells cannot be sufficiently expanded in all patients 23 ; but when they can be expanded, they retain cytotoxic activity and Th1 cytokine secretion very well. Therefore, we conducted phase I clinical studies to evaluate the safety and potential antitumor effects of the adoptive transfer of autologous Vγ9Vδ2 T-cells expanded from patients with NSCLC, 24 colorectal cancer, 22 pancreatic cancer 25 and gastric cancer.…”
Section: Introductionmentioning
confidence: 99%
“…This shift of Vδ1 T cells was not observed for the total γδ T cell population ( Figures 2B,C , upper panel) and also not within the Vδ2 subpopulation ( Figures 2B,C , lower panel). Moreover, the CD27 − CD45RA ++ population which has been described as a dysfunctional subpopulation with limited proliferation capacity ( 41 ) was significantly increased within the BM-derived Vδ1 T cells in AML and MM in comparison to HDs (HD vs. AML p = 0.036; HD vs. MM p = 0.026, respectively, Figure 2D ).…”
Section: Resultsmentioning
confidence: 99%