CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells

Fontenot, Andrew P.; Gharavi, Laia; Bennett, Sean; Canavera, Scott J.; Newman, Lee S.; Kotzin, Brian L.

doi:10.1172/jci18317

Cited by 33 publications

(60 citation statements)

References 53 publications

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“…With T-cell differentiation, effector memory cells become independent of CD28-mediated co-stimulation, with the eventual loss of CD28 expression [45]. Central memory CD4 C T cells are capable of differentiating into effector memory cells [70].…”

Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

“…Analysis of CD28 expression on CD4 C T cells from CBD patients shows that the percentage of CD28-negative CD4 C cells is increased dramatically in the lungs and is also increased, although less so, in the blood [45]. The loss of surface CD28 expression on BAL CD4 C cells correlates with the severity of the CD4 C T-cell alveolitis [45].…”

Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

“…The loss of surface CD28 expression on BAL CD4 C cells correlates with the severity of the CD4 C T-cell alveolitis [45]. Blockade of the CD28-B7 interaction fails to inhibit either BeSO 4 -induced proliferation or Th1-type cytokine secretion by BAL-derived beryllium-specific CD4 C T cells whereas markedly reduced responses are seen in blood [45]. These findings suggest a transition within the memory CD4 C T-cell population from CD28 dependence in central memory cells (in blood) to a functional independence followed by the eventual loss of CD28 expression in effector memory cells.…”

Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

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Genetic susceptibility and immune-mediated destruction in beryllium-induced disease

Fontenot

Maier

2005

Trends in Immunology

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Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

Section: Beryllium-specific Cd4 C T Cells In Cbdmentioning

confidence: 99%

See 2 more Smart Citations

Genetic susceptibility and immune-mediated destruction in beryllium-induced disease

Fontenot

Maier

2005

Trends in Immunology

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“…2 These lung T cells recognize beryllium in a CD28-independent manner, whereas those cells in blood remain dependent on CD28 costimulation for optimal T-cell activation. 3 These findings suggest that lung CD4 1 T cells are more differentiated than those in blood. Thus, a more intimate understanding of functional differences between beryllium-specific CD4 1 T cells in these 2 compartments may further our understanding of the immunopathogenesis of CBD and other immune-mediated diseases characterized by an inaccessible target organ.…”

mentioning

confidence: 91%

CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease

Palmer¹,

Mack²,

Martin³

et al. 2007

Journal of Allergy and Clinical Immunology

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Evaluation of Histologic, Serologic, and Clinical Changes in Response to Abatacept Treatment of Primary Sjögren's Syndrome: A Pilot Study

Adler

Körner

Förger

et al. 2013

Arthritis Care & Research

111

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Objective. To prospectively evaluate histopathologic, blood cellular, serologic, and clinical changes in response to abatacept treatment in patients with primary Sjögren's syndrome (SS). Methods. Blood, saliva, and minor salivary gland biopsy samples were obtained before and after the last of 8 doses of abatacept in 11 primary SS patients. The histologic data evaluated the numbers of lymphocytic foci and B and T cell subtypes (CD20؉, CD3؉, CD4؉, and CD8؉). The numbers of FoxP3؉ regulatory T cells were measured and the FoxP3:CD3 ratio was calculated. Histologic data were compared with results from peripheral blood and with changes in saliva secretion. Results. The numbers of lymphocytic foci decreased significantly (P ‫؍‬ 0.041). Numbers of local FoxP3؉ T cells decreased significantly in percentage of total lymphocytic infiltrates (P ‫؍‬ 0.037). In the peripheral blood, B cells increased (P ‫؍‬ 0.038). This was due to an expansion of the naive B cell pool (P ‫؍‬ 0.034). When adjusting for disease duration, an increase was also noted for total lymphocytes (P ‫؍‬ 0.044) and for CD4 cells (P ‫؍‬ 0.009). Gamma globulins decreased significantly (P ‫؍‬ 0.005), but IgG reduction did not reach significance. Adjusted for disease duration, saliva production increased significantly (P ‫؍‬ 0.029). Conclusion. CTLA-4Ig treatment significantly reduces glandular inflammation in primary SS, induces several cellular changes, and increases saliva production. Remarkably, this increase in saliva production is significantly influenced by disease duration.

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CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells

Cited by 33 publications

References 53 publications

Genetic susceptibility and immune-mediated destruction in beryllium-induced disease

Genetic susceptibility and immune-mediated destruction in beryllium-induced disease

CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease

Evaluation of Histologic, Serologic, and Clinical Changes in Response to Abatacept Treatment of Primary Sjögren's Syndrome: A Pilot Study

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