CD28 costimulation regulates FOXP3 in a RelA/NF‐κB‐dependent mechanism

Soligo, Marzia; Camperio, Cristina; Caristi, Silvana; Scottà, Cristiano; Porto, Paola Del; Costanzo, Antonio; Mantel, Pierre‐Yves; Schmidt‐Weber, Carsten B.; Piccolella, Enza

doi:10.1002/eji.201040712

Cited by 32 publications

(29 citation statements)

References 29 publications

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“…We also saw a significant up-regulation of CD38 mRNA expression after the graft was subjected to 8 h CI (3.5 6 0.8 ng versus 5.5 6 1.6 ng, P < 0.05). However, regulatory T cells which suppress allogeneic immune response also express CD25 on the cellular surface, the up-regulation of CD28 may be associated with the increased regulatory T cells [28,29]. In order to exclude the possibility that the up-regulation of CD25 and CD28 was caused by increased number of regulatory T cells, we assessed the mRNA expression of Foxp3.…”

Section: Mrna Expression Of T-cell Activation Markers and Clt Relatedmentioning

confidence: 99%

Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models

Jin

Dahmen

Liu

et al. 2012

Journal of Surgical Research

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Section: Mrna Expression Of T-cell Activation Markers and Clt Relatedmentioning

confidence: 99%

Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models

Jin

Dahmen

Liu

et al. 2012

Journal of Surgical Research

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“…An alternative explanation for a role for c-Rel has suggested c-Rel is involved in chromatin remodeling of the IL-2 promoter (Rao et al, 2003). c-Rel does appear to contribute to the expression of Foxp3 and the development of Treg cells in the thymus (Isomura et al, 2009; Long et al, 2009; Ruan et al, 2009) but another NF-κB family member RelA may be more important for induced Treg cell production in the periphery (Soligo et al, 2011). A further post-translational protein modification that may contribute to CD28-mediated T cell activation is O-GlcNAc glycosylation.…”

Section: The Cd28 Costimulatory Pathway Regulates T Cell Activation Bmentioning

confidence: 99%

CD28 Costimulation: From Mechanism to Therapy

et al. 2016

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Summary Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here we discuss the expression, structure, and biochemistry of CD28 and its ligands. CD28 signals play a key role in many T cell processes including cytoskeletal remodeling, production of cytokines, survival, and differentiation. CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be recapitulated by TCR ligation alone. We discuss the function of CD28 and its ligands in both effector and regulatory T cells. CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis. We outline the roles that CD28 and its family members play in human disease and we review the clinical efficacy of drugs that block CD28 ligands. Despite the centrality of CD28 and its family members and ligands to immune function, many aspects of CD28 biology remain unclear. Translation of a basic understanding of CD28 function into immunomodulatory therapeutics has been uneven with both successes and failures. Such real-world results may stem from multiple factors including complex receptor-ligand interactions among CD28 family members, differences between the mouse and human CD28 families, and cell-type specific roles of CD28 family members.

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“…69,95,96 More recent studies have shown how the cooperative expression of c-Rel and JunB significantly enhances Foxp3 promoter activity, 97 and the role of RelA has also been observed to be important for iTreg cell differentiation in a CD28 signal-dependent manner. 98 …”

Section: Epigenetic and Transcriptional Regulation Of Foxp3mentioning

confidence: 99%

Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells

et al. 2011

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CD4þ CD25 þ regulatory T (Treg) cells engage in the maintenance of immunological self-tolerance and homeostasis by limiting aberrant or excessive inflammation. The transcription factor forkhead box P3 (FOXP3) is critical for the development and function of Treg cells. The differentiation of the Treg cell lineage is not terminal, as developmental and functional plasticity occur through the sensing of inflammatory signals in the periphery. Here, we review the recent progress in our understanding of the molecular mechanisms underlying the regulation and functional plasticity of CD4 þ CD25 þ FOXP3 þ Treg cells, through the perturbation of FOXP3 and its complex at a transcriptional, translational and post-translational level.

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CD28 costimulation regulates FOXP3 in a RelA/NF‐κB‐dependent mechanism

Cited by 32 publications

References 29 publications

Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models

Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models

CD28 Costimulation: From Mechanism to Therapy

Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells

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