CD2AP mRNA in urinary exosome as biomarker of kidney disease

Lv, Lin‐Li; Cao, Yuhan; Pan, Mingming; Liu, Hong; Tang, Ri‐Ning; Ma, Kun-Ling; Chen, Pingsheng; Liu, Bi‐Cheng

doi:10.1016/j.cca.2013.10.003

Cited by 103 publications

(74 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, in patients with kidney disease CD2AP mRNA was associated with urinary exosomes (79). Several specific proteins have been identified in exosomes isolated from: (1) the urine of healthy individuals (CD24 and Aquaporin 2) (80), (2) sera from cancer patients (MUC1, LRG1, Hsp90a, and RAD21) (81), (3) the placenta (syncytin-1) (82), and 4) from patients with multiple sclerosis (IB4) (83).…”

Section: Role Of Treg Exosomes In Transplantationmentioning

confidence: 99%

Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation

et al. 2014

View full text Add to dashboard Cite

Exosomes are extracellular vesicles released by many cells of the body. These small vesicles play an important part in intercellular communication both in the local environment and systemically, facilitating in the transfer of proteins, cytokines as well as miRNA between cells. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulate the immune response has paved the way for these structures to be considered as potential immunotherapeutic reagents. Indeed, clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. Exosomes can also have a negative effect on the immune response and exosomes isolated from regulatory T cells (Tregs) and other subsets of T cells have been shown to have immune suppressive capacities. Here, we review what is currently known about Treg derived exosomes and their contribution to immune regulation, as well as highlighting their possible therapeutic potential for preventing graft rejection, and use as diagnostic tools to assess transplant outcome.

show abstract

Section: Role Of Treg Exosomes In Transplantationmentioning

confidence: 99%

Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Renal fibrosis microRNA29c [34] Renal fibrosis CD2AP [35] Chronic kidney disease Osteoprotegerin [44] Glomerular disease Puromycin-treated rats or podocin-Vpr transgenic mice and from patients with focal segmental glomerulosclerosis Wilms tumor 1 [10] IgA nephropathy versus thin basement membrane nephropathy a Aminopeptidase N, vasorin precursor, α-1-antitrypsin, and ceruloplasmin [45] (continued)…”

Section: Urinary Exosomes In Biomarker Discoverymentioning

confidence: 98%

“…In addition to being a great source of protein biomarkers, exosomes also contain functional mRNA and miRNA, which markedly expands the potential repertoire of biomarkers. In recent studies, for example, mRNA and miRNA in urinary exosomes were used to identify potential markers for prostate cancer and renal fibrosis [34][35][36]. In many cases, early detection of a disease or injury is required for increasing the chances of successful treatment, and several of the biomarkers already discovered could provide early detection possibilities.…”

Section: Urinary Exosomes In Biomarker Discoverymentioning

confidence: 99%

Exosomes in Urine Biomarker Discovery

Huebner

Somparn

Benjachat

et al. 2014

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Nanovesicles present in urine the so-called urinary exosomes have been found to be secreted by every epithelial cell type lining the urinary tract system in human. Urinary exosomes are an appealing source for biomarker discovery as they contain molecular constituents of their cell of origin, including proteins and genetic materials, and they can be isolated in a non-invasive manner. Following the discovery of urinary exosomes in 2004, many studies have been performed using urinary exosomes as a starting material to identify biomarkers in various renal, urogenital, and systemic diseases. Here, we describe the discovery of urinary exosomes and address the issues on the collection, isolation, and normalization of urinary exosomes as well as delineate the systems biology approach to biomarker discovery using urinary exosomes.

show abstract

“…In addition to the imaging advancements described above, these studies have defined podocyte-specific gene splicing patterns [91], produced a computationally defined signature to evaluate how diseases affect the podocyte [92], contributed to a growing list of urinary biomarkers for podocyte injury [93][94][95][96] and generated a comprehensive podocyte protein-protein interaction network [97] -leading to the characterization of several novel podocyte proteins [98,99]. Further, the application of systems biology methods to the podocyte has enormous potential in the pursuit of personalized medicine in nephrology, wherein we can better predict the effects of therapeutic combinations and suggest patient-specific drug intervention strategies [100].…”

Section: How Does Nephrin Tyrosine Phosphorylation Affect the Slit DImentioning

confidence: 99%