2009
DOI: 10.1111/j.1365-2249.2009.03974.x
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CD3 expression distinguishes two γδT cell receptor subsets with different phenotype and effector function in tuberculous pleurisy

Abstract: SummaryTuberculous pleurisy is a naturally occurring site of Mycobacterium tuberculosis (Mtb) infection. Herein, we describe the expression of activation, natural killer (NK) and cell migration markers, as well as effector functions from gdT cells in peripheral blood (PB) and pleural effusion (PE) from tuberculosis patients (TB). We observed a decreased percentage of circulating gdT from TB patients and differential expression of NK as well as of chemokine receptors on PB and PE. Two subsets of gdT cells were … Show more

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Cited by 25 publications
(23 citation statements)
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“…Observed for ED1 and ED14, the majority of the γδ T population expressing TCRγδ lo/ CD3 hi cells had dominant Vδ1 usage (Figure e). This was converse to previous studies showing predominant Vδ2 usage in the TCRγδ lo/ CD3 hi subset, suggesting that the TCRγ lo /CD3 hi in the elderly may reflect recent TCR‐dependent activation. The subset of γδ T cells expressing TCRγδ hi /CD3 lo had the predominant usage of Vδ2 paired with Vγ2 (ED1, Figure e, Supplementary tables 3 and 4), where Vδ2 paired with Vγ9 or Vδ1 paired with Vγ4 (ED14, Figure e, Supplementary table 4, Supplementary figure 6c, Supplementary table 3).…”
Section: Resultscontrasting
confidence: 77%
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“…Observed for ED1 and ED14, the majority of the γδ T population expressing TCRγδ lo/ CD3 hi cells had dominant Vδ1 usage (Figure e). This was converse to previous studies showing predominant Vδ2 usage in the TCRγδ lo/ CD3 hi subset, suggesting that the TCRγ lo /CD3 hi in the elderly may reflect recent TCR‐dependent activation. The subset of γδ T cells expressing TCRγδ hi /CD3 lo had the predominant usage of Vδ2 paired with Vγ2 (ED1, Figure e, Supplementary tables 3 and 4), where Vδ2 paired with Vγ9 or Vδ1 paired with Vγ4 (ED14, Figure e, Supplementary table 4, Supplementary figure 6c, Supplementary table 3).…”
Section: Resultscontrasting
confidence: 77%
“…Such clonal expansions led to a non‐normal distribution and distinct CDR3 γδ lengths across different elderly donors. This is the first report of clonal expansions of paired γδ TCRs in elderly adults, with clonal divergence often being associated with differences between the ratio of cell surface expressed TCRγδ and CD3 …”
Section: Discussionmentioning
confidence: 87%
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“…Such a classification across species would represent a significant step in understanding the functional dichotomy of γδ T‐cell subsets. Of note, a subset of human γδ T cells showing a bright expression of CD3 has already been demonstrated in patients with tuberculous pleurisy 62 . In line with our hypothesis, these cells were predominantly Vδ2 + , 62 a subset of human γδ T cells with high capacity in IL‐17 production 57 …”
Section: Discussionsupporting
confidence: 79%
“…This behavior resembles that of adaptive immunity cells and suggests that Vg9Vd2 cells may contribute to adaptive immunity to mycobacterial infections. In pleural effusions of TB patients, two populations of gd cells were identified as TCR low Vd2 þ and TCR high Vd1 þ (Yokobori et al 2009). The Vd2 cells were CD45RA þ/2 CCR7 þ CXCR3 þ , released large amounts of IFN-g, and expressed the CD107a marker, indicating a status of activated cells within the tissue.…”
Section: Role Of Gd Cells In Tbmentioning
confidence: 99%