CD3+T, CD4+T, CD8+T, and CD4+T/CD8+T Ratio and Quantity of γδT Cells in Peripheral Blood of HIV-Infected/AIDS Patients and Its Clinical Significance

Zhao, Nange; Zhang, Tingting; Zhao, Yongqiang; Zhang, Jianping; Wang, Keqiang

doi:10.1155/2021/8746264

Cited by 13 publications

(11 citation statements)

References 17 publications

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“…The increased hydrophobic angle indicates the increased hydrophobic performance of the device. [61][62][63] BPQDs can optimize the crystalline quality of the perovskite film and reduce the surface area of the grain boundary in contact with water molecules, which improves the moisture and hydrophobic properties of the perovskite film to a certain extent. Defects at the surface and grain boundaries of perovskite films affect the long-term stability and humidity stability of the device.…”

Section: Resultsmentioning

confidence: 99%

Light Management through Organic Bulk Heterojunction and Carrier Interfacial Engineering for Perovskite Solar Cells with 23.5% Efficiency

Shi

Zhou

Zhuang

et al. 2022

Adv Funct Materials

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Light management through organic bulk heterojunction (BHJ) has been widely reported to push up the performance of lead-based perovskite solar cells (PSCs) by extending the spectral response. However, the development of integrated perovskite/organic bulk heterojunction solar cells (IPSCs) encounters a bottleneck problem that the poor carrier extraction capability of perovskite and BHJ leads to the severe loss of open-voltage (V oc ) and fill factor (FF). Herein, the strategy of introducing black phosphorous quantum dots (BPQDs) and cuprous oxide (CuO x ) into IPSCs is adopted, which not only successfully extends the single-component PSCs light response to 930 nm, but also significantly reduces the V oc and FF loss of IPSCs. BPQDs with bipolar charge transport and high mobility characteristics improves the electron/hole transport behaviors of perovskite and BHJ films. CuO x with matching energy levels is introduced between BHJ and Spiro-OMeTAD as a buffer layer, which provides good driving force for the transportation of holes. The champion device achieves a power conversion efficiency of 23.52%. The IPSCs devices also display an excellent long-term and humidity stability. This work demonstrates an approach to solve the carrier extraction key issues that limits the performance of IPSCs, which achieves an instructive result in the development of PSCs light management.

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Section: Resultsmentioning

confidence: 99%

Light Management through Organic Bulk Heterojunction and Carrier Interfacial Engineering for Perovskite Solar Cells with 23.5% Efficiency

Shi

Zhou

Zhuang

et al. 2022

Adv Funct Materials

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“…Furthermore, higher counts of immune cells, such as B-cells and T-CD4, as well as higher IgG levels, prior the immunization protocol favoured the response to the COVID-19 vaccine. The correct ratios of immune subsets are known to be critical during viral infections, such as the CD4/CD8 ratio in HIV-infection ( 7 ), or the total CD4+ and CD8+ T-cells producing IFN-γ or TNF-α as predictors of the immune response after vaccination against tuberculosis and herpes zoster ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

“…The distribution of immune cell populations impacts the outcome of immune responses to different viral infections and vaccination settings such as the CD4/CD8 T-cell ratio in HIV-infected subjects ( 7 ), or the total CD4+ and CD8+ T-cells producing IFN-γ or TNF-α in tuberculosis and herpes zoster vaccination ( 8 , 9 ). In addition, delayed reconstituted T and B cells have been related to a higher risk of viral infection after stem cell transplantation ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients

Bulnes-Ramos

Pozo-Balado²,

Olivas-Martínez³

et al. 2023

Front. Immunol.

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IntroductionKidney transplant recipients showed a weak humoral response to the mRNA COVID-19 vaccine despite receiving three cumulative doses of the vaccine. New approaches are still needed to raise protective immunity conferred by the vaccine administration within this group of high-risk patients. MethodsTo analyze the humoral response and identify any predictive factors within these patients, we designed a prospective monocentric longitudinal study of Kidney transplant recipients (KTR) who received three doses of mRNA-1273 COVID-19 vaccine. Specific antibody levels were measured by chemiluminescence. Parameters related to clinical status such as kidney function, immunosuppressive therapy, inflammatory status and thymic function were analyzed as potential predictors of the humoral response. ResultsSeventy-four KTR and sixteen healthy controls were included. One month after the administration of the third dose of the COVID-19 vaccine, 64.8% of KTR showed a positive humoral response. As predictive factors of seroconversion and specific antibody titer, we found that immunosuppressive therapy, worse kidney function, higher inflammatory status and age were related to a lower response in KTR while immune cell counts, thymosin-a1 plasma concentration and thymic output were related to a higher humoral response. Furthermore, baseline thymosin-a1 concentration was independently associated with the seroconversion after three vaccine doses. DiscussionIn addition to the immunosuppression therapy, condition of kidney function and age before vaccination, specific immune factors could also be relevant in light of optimization of the COVID-19 vaccination protocol in KTR. Therefore, thymosin-a1, an immunomodulatory hormone, deserves further research as a potential adjuvant for the next vaccine boosters.

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“…In addition, many other PID, such as hyper-IgM syndrome [9], are amenable to diagnosis by flow cytometry using antibodies specific to the molecule with impaired expression. Among secondary immunodeficiencies, by far the most important indication for immunophenotyping is the need for enumeration of CD4 + T lymphocytes in human immunodeficiency virus (HIV)-infected persons [10]. The method is also used in monitoring the effects of immunosuppressive treatment, particularly when rituximab is administered, or planned to be administered [11].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic significance of immunophenotyping of peripheral blood lymphocytes in pediatric patients from the Autonomous Province of Vojvodina, Republic of Serbia

et al. 2023

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Introduction/Objective. Although lymphocyte immunophenotyping based on flow cytometry is a powerful tool in the diagnosis of many primary immunodeficiences (PID), there has been an increasing awareness of associated costs and the need for its reassessment as a screening tool. We present the results and diagnostic impact of immunophenotyping performed by flow cytometry in the University Children?s Hospital, Belgrade, in a series of patients referred from the Institute for Child and Youth Health Care of Vojvodina from July 2008 to July 2018. Methods. We reviewed the laboratory reports on numbers of B lymphocytes (CD19+), T lymphocytes (CD3+), natural killer (NK) cells (CD3-CD16/CD56+) and activated T cells (CD3+HLA-DR+), as well as CD4+ and CD8+ T cells in 198 children. Results Patients were grouped by stated indication into the following eight categories: hypogammaglobulinemia (34), selective IgA deficiency and/or IgG subclass deficiency (43), various infections with no immunoglobulin deficiencies (67), asthma and/or allergies with no immunoglobulin deficiencies or infections (23), known or suspected autoimmune disorders (24), and miscellaneous diagnoses not accompanied by infections (7). In total, 159 (80.3%) findings were either completely within the respective reference range or exhibited only minimal aberrations. Four patients were diagnosed with Bruton?s disease and one with Artemis immunodeficiency. Nineteen patients were given immunoglobulin substitution to control infections and/or maintain immunoglobulin G levels. Conclusion. Lymphocyte immunophenotyping aids the diagnosis of PID in selected patients. We venture some thoughts on how the usefulness of this laboratory method could be improved in real-life tertiary care pediatric hospital settings.

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CD3+T, CD4+T, CD8+T, and CD4+T/CD8+T Ratio and Quantity of γδT Cells in Peripheral Blood of HIV-Infected/AIDS Patients and Its Clinical Significance

Cited by 13 publications

References 17 publications

Light Management through Organic Bulk Heterojunction and Carrier Interfacial Engineering for Perovskite Solar Cells with 23.5% Efficiency

Light Management through Organic Bulk Heterojunction and Carrier Interfacial Engineering for Perovskite Solar Cells with 23.5% Efficiency

Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients

Diagnostic significance of immunophenotyping of peripheral blood lymphocytes in pediatric patients from the Autonomous Province of Vojvodina, Republic of Serbia

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