CD30/Ki-1-positive lymphoproliferative disorders of the skin--clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group.

Abstract

Our findings indicate that CD30+ cutaneous lymphoproliferative disorders comprise a spectrum of closely related skin lesions, which can be assigned a relatively favorable or unfavorable prognosis by a combined clinical and pathologic analysis.

EBV Positive Primary Cutaneous CD30+ Large T-Cell Lymphoma in a Heart Transplanted Patient: Case Report

“…Primary cutaneous CD30+ ALCLs uniformly lack the t(2;5) and ALK expression (13). Despite this, they usually have a favourable prognosis and are highly responsive to external radiotherapy and cytotoxic chemotherapy (either alone or in combination) (14,15).…”

Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas

“…94,[245][246][247] It has been suggested that LyP is a precursor lesion of primary cutaneous ALCL. The studies summarized in Table 12 indicate that the t(2;5) NPM-ALK is Leukemia absent in LyP (except for one study) and rare in most studies on primary cutaneous CD30 + ALCL.…”

Immunohistochemical Analysis of CD30-Positive Lymphoproliferative Disorders for Expression of CD95 and CD95L

“…The relationship between these entities is supported by the conversion of LyP to CD30-positive ALCL in a minority of cases (1,5). In contrast, there is mounting evidence that noncutaneous CD30-positive ALCL, although morphologically similar to its cutaneous counterpart, is biologically distinct.…”

“…Criteria for the histologic distinction between these two entities are imprecise, at times causing a diagnostic dilemma. Ultimately, LyP and PC CD30-positive ALCL have both histologic and clinical overlap, prompting some to consider these entities as ends of a spectrum of PC CD30-positive LPDs (1,4).…”

“…Lymphomatoid papulosis (LyP) and primary cutaneous (PC) CD30-positive anaplastic large cell lymphoma (ALCL) belong to the spectrum of PC lymphoproliferative disorders (LPDs) associated with a favorable prognosis that has been attributed to the expression of CD30 (1,2). Classically, LyP and PC CD30-positive ALCL differ with respect to clinical presentation.…”