CD30‐positive lymphoproliferative disorders arising after regional therapy for recurrent melanoma: A report of two cases and analysis of CD30 expression

Gill, Kamraan Z.; Ariyan, Charlotte E.; Wang, Xuan; Brady, Mary S.; Pulitzer, Melissa

doi:10.1002/jso.23636

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…An association between increased latitude or distance from equator and increased prevalence of mature NK and TCL, including PC‐ALCL, perhaps suggests a modulatory effect of ultraviolet radiation . Increases in CD30+ lymphocytes have been shown in the extremities of patients given regional chemotherapy for recurrent melanoma, with at least 1 case of PC‐ALCL reported . Carbamazepine‐associated PC‐ALCL has also been documented…”

Section: Etiology and Pathogenesismentioning

confidence: 97%

Primary cutaneous anaplastic large cell lymphoma

2017

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Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease.CD30+ LPDs comprise approximately 25%-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T-cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC-ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms. K E Y W O R D SCD30+ lymphoproliferative disorder, primary cutaneous anaplastic large cell lymphoma

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Section: Etiology and Pathogenesismentioning

confidence: 97%

Primary cutaneous anaplastic large cell lymphoma

2017

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“…3c ) CCL17 and CCL22 to CCR4 interactions were strongest to the AXL population and these ligands have been shown to increase metastasis formation of CCR4 expressing melanoma cells ( Klein et al , 2017 ). The CD30 ligand to CD30 interaction was also higher to the AXL population, which is interesting as CD30 has been shown to be up-regulated in T-cells following malignant melanoma treatment ( Gill et al , 2014 ). The neurotensin to neurotensin receptor 2 interaction is stronger to the MITF cells, and the major source of neurotensin is endothelial cells and AXL cells.…”

Section: Resultsmentioning

confidence: 78%

scConnect: a method for exploratory analysis of cell–cell communication based on single-cell RNA-sequencing data

2021

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Motivation Cell to cell communication is critical for all multicellular organisms, and single cell sequencing facilitates the construction of full connectivity graphs between cell types in tissues. Such complex data structures demand novel analysis methods and tools for exploratory analysis. Results We propose a method to predict the putative ligand-receptor interactions between cell types from single cell RNA-sequencing data. This is achieved by inferring and incorporating interactions in a multidirectional graph, thereby enabling contextual exploratory analysis. We demonstrate that our approach can detect common and specific interactions between cell types in mouse brain and human tumors, and that these interactions fit with expected outcomes. These interactions also include predictions made with molecular ligands integrating information from several types of genes necessary for ligand production and transport. Our implementation is general and can be appended to any transcriptome analysis pipeline to provide unbiased hypothesis generation regarding ligand to receptor interactions between cell populations or for network analysis in silico. Availability scConnect is open source and available as a Python package athttps://github.com/JonETJakobsson/scConnect. scConnect is directly compatible with Scanpy scRNA-sequencing pipelines. Supplementary information Supplementary data are available at Bioinformatics online.

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Case 22. Infusion-related CD30-positive lymphomatoid drug eruption secondary to melphalan

Matsumoto

Akilov

2021

Cutaneous Lymphomas

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CD30‐positive lymphoproliferative disorders arising after regional therapy for recurrent melanoma: A report of two cases and analysis of CD30 expression

Cited by 4 publications

References 41 publications

Primary cutaneous anaplastic large cell lymphoma

Primary cutaneous anaplastic large cell lymphoma

scConnect: a method for exploratory analysis of cell–cell communication based on single-cell RNA-sequencing data

Case 22. Infusion-related CD30-positive lymphomatoid drug eruption secondary to melphalan

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