CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies

Prieto‐Torres, Lucía; Rodríguez‐Pinilla, Socorro María; Onaindía, Arantza; Ara, Mariano; Requena, Luís; Piris, Miguel Á.

doi:10.3324/haematol.2018.197152

Cited by 42 publications

(50 citation statements)

References 106 publications

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“…ALK positivity by immunohistochemistry has been found in only a handful of cases of pcALCL and these cases showed a favorable prognosis (85) unlike their systemic counterpart. ALK translocation has not been found in pcALCL to date (79).…”

Section: Lypmentioning

confidence: 94%

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An Update on Molecular Biology of Cutaneous T Cell Lymphoma

Walia

Yeung

2020

Front. Oncol.

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Cutaneous T cell lymphomas represent a heterogenous group of lymphoproliferative disorders defined by clonal proliferation of T cells present in the skin. The latest WHO classification in 2016 and WHO-EORTC classification in 2018 has updated the classification of these entities based on the molecular profile. Research in the field of molecular genetics of CTCL has allowed a better understanding of the biology of these tumors and has helped to identify potential targets for therapy that can be tailored to individual patients. In this review, we discuss the latest developments in the molecular profile of CTCLs including biomarkers for diagnosis, prognosis, and potential therapeutic targets. We have also touched upon the utility of various molecular diagnostic modalities. For the purpose of this review, we researched papers in PubMed indexed journals in English literature published in the past 20 years using keywords CTCL, mycosis fungoides, molecular profile, molecular diagnosis, whole genome profile, genomic landscape, TCR clonality.

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Section: Lypmentioning

confidence: 94%

“…There are various differences between pc ALCL and systemic ALCL on molecular level. Most cases of pcALCL are negative for classic chromosomal rearrangements seen in systemic ALCL-ALK, DUSP22/IRF4, and TP63 (79). DUSP/IRF4 rearrangement is found in 20% pcALCLs (78) and show a biphasic histological pattern similar to LyP with this alteration (80).…”

Section: Lypmentioning

confidence: 99%

An Update on Molecular Biology of Cutaneous T Cell Lymphoma

Walia

Yeung

2020

Front. Oncol.

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“…Rearrangements of DUSP22 can be present in both, and thus are not discriminant. [156][157][158] The distinction ultimately relies on clinical staging. Breast implant-associated ALCL may disseminate to lymph nodes, with a sinusoidal pattern of involvement, often associated with perifollicular, interfollicular, and diffuse patterns.…”

Section: Alcl Versus Diffuse Large B-cell Lymphoma (Dlbcl)mentioning

confidence: 99%

Approach to nodal-based T-cell lymphomas

Leval

2020

Pathology

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Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of uncommon malignancies derived from mature T cells and usually characterised by an aggressive clinical course. Their clinical presentation, localisation and pattern of dissemination are highly variable, but the majority of cases present as nodal diseases. The recently revised classification of lymphomas has incorporated many new molecular genetic data derived from gene expression profiling and next generation sequencing studies, which refine the definition and diagnostic criteria of several entities. Nevertheless, the distinction of PTCL from various reactive conditions, and the diagnosis of PTCL subtypes remains notably challenging. Here, an updated summary of the clinicopathological and molecular features of the most common nodal-based PTCLs (angioimmunoblastic T-cell lymphoma and other nodal lymphomas derived from follicular T helper cells, anaplastic large cell lymphomas and peripheral T-cell lymphoma, not otherwise specified) is presented. Practical recommendations in the diagnostic approach to nodal T-cell lymphoproliferations are presented, including indications for the appropriate use and interpretation of ancillary studies. Finally, we discuss commonly encountered diagnostic problems, including pitfalls and mimics in the differential diagnosis with various reactive conditions, and the criteria that allow proper identification of distinct PTCL entities.

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“…We are not aware about previous studies reporting on this subject in patients with PCALCL but early relapse is a known significant prognostic factor in follicular lymphoma . Genetic and epigenetic features in PCALCL may underlie this heterogeneity but definite evidence is lacking.…”

Section: Discussionmentioning

confidence: 93%

Prognostic factors in patients with primary cutaneous anaplastic large cell lymphoma: a multicentric, retrospective analysis of the Spanish Group of Cutaneous Lymphoma

Fernández-de-Misa

Hernández‐Machín²,

Combalía

et al. 2019

Acad Dermatol Venereol

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Background Reliable prognostic factors for patients with primary cutaneous anaplastic large cell lymphoma (PCALCL) are lacking. Objective To identify prognostic factors for specific survival in patients with PCALCL. Methods Using the convenience sampling method, patients with PCALCL diagnosed from May 1986 to August 2017 in 16 University Departments were retrospectively reviewed. Results One hundred eight patients were included (57 males). Median age at diagnosis was 58 years. All of them showed T1‐3N0M0 stages. Seventy per cent of the cases presented with a solitary lesion, mostly at the limbs. Complete response rate after first‐line treatment was 87%, and no advantage was observed for any of them (surgery, radiotherapy, chemotherapy or other approaches). Nodal and visceral progression rate was 11% and 2%, respectively. 5‐year specific survival (SSV) reached 93%; 97% for T1 patients and 84% for T2/T3 patients (P = 0.031). Five‐year SSV for patients developing early cutaneous relapse was 64%; for those with late or no relapse, 96% (P = 0.001). Estimated median SSV for patients showing nodal progression was 103 months (95% CI: 51–155 months); for patients without nodal progression, estimated SSV did not reach the median (P < 0.001). Nodal progression was an independent predictive parameter for shorter survival (P = 0.011). Conclusion Multiple cutaneous lesions at presentation, early skin relapse and nodal progression portrait worse prognosis in patients with PCALCL.

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CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies

Cited by 42 publications

References 106 publications

An Update on Molecular Biology of Cutaneous T Cell Lymphoma

An Update on Molecular Biology of Cutaneous T Cell Lymphoma

Approach to nodal-based T-cell lymphomas

Prognostic factors in patients with primary cutaneous anaplastic large cell lymphoma: a multicentric, retrospective analysis of the Spanish Group of Cutaneous Lymphoma

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