CD300f is a potential therapeutic target for the treatment of food allergy

Uchida, Shino; Izawa, Kumi; Ando, Tomoaki; Yamada, Hiromichi; Uchida, Koichiro; Negishi, Naoko; Kaitani, Ayako; Maehara, Akie; Nagamine, Masakazu; Kamei, Anna; Takamori, Ayako; Maeda, Keiko; Nakano, Nobuhiro; Shimizu, Toshiaki; Ogawa, Hideoki; Okumura, Ko; Nagahara, Akihito; Watanabe, Sumio; Kitaura, Jiro

doi:10.1111/all.14034

Cited by 20 publications

(31 citation statements)

References 10 publications

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“…Moreover, ceramide also inhibits ATP‐mediated MC activation to suppress experimental colitis via CD300f (Matsukawa et al, 2016). Because CD300f has a regulatory effect on MC activity, it might be a potential therapeutic target for the treatment of food allergies (Uchida et al, 2020). Since the calcium signaling pathway plays an important role in many physiological functions, inhibiting its activation to reduce the activation of MRGPRX2 might lead to other effects, whereas CD300f is highly expressed in MCs, and inhibiting the activation of MRGPRX2 via CD300f could have a more specific effect.…”

Section: Discussionmentioning

confidence: 99%

Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction

Che

Zheng

Hou³

et al. 2022

Phytotherapy Research

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Mas-related G protein-coupled receptor X2 (MRGPRX2) mediates mast cells (MCs) activation, which is a key target for the treatment of allergic diseases. However, there are few drugs targeting MRGPRX2. Leukocyte mono-immunoglobulin-like receptor 3 (CD300f) is a negative regulator of FcεRΙ-mediated MC activation. However, the regulatory effect of CD300f on MRGPRX2 remains unclear. Dehydroandrographolide (DA) is a main contributor of Andrographis paniculata (Burm.f.) Nees (family: Acanthaceae) have been shown to inhibit type I hypersensitivity. The aim of this study was to determine whether DA negatively regulated MRGPRX2-mediated MC activation via CD300f and showed therapeutic effect on pseudo-allergic reactions. Mouse allergic models and MC degranulation were detected in vivo and in vitro, and inflammatory mediators were detected. siRNA interference and Biacore were used to verify the target. DA inhibited pseudo-allergic reactions by reducing vasodilation and serum cytokine levels in mice and inhibited MRGPRX2-mediated MC activation. The regulatory effect of DA was significantly decreased after the knockdown of CD300f expression. Moreover, DA upregulated the phosphorylation level of Src homology region 2 domain-containing phosphatase (SHP)-1 and SHP-2, which are key kinases in the negative regulatory signaling pathways associated with CD300f. In conclusion, DA negatively regulates MRGPRX2-mediated MC activation via CD300f to inhibit pseudo-allergic reactions.

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Section: Discussionmentioning

confidence: 99%

Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction

Che

Zheng

Hou³

et al. 2022

Phytotherapy Research

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“…Src homology 2 domain-containing protein phosphatase (SHP)-1 and -2, which are recruited to the phosphorylated ITIMs and ITSM, negatively regulate high-affinity IgE receptor FcεRI-mediated signaling, resulting in the suppression of IgEmediated mast cell activation. Uchida et al [87] have shown that CD300f is also expressed on the cell surface of MMCs, MMC9, and β7 integrin + MCp in the small intestinal lamina propria in mice. In a mouse model of IgE-mediated food allergy, the serum level of mMCP-1, a marker of MMC activation, was higher in CD300f-deficient mice than in wildtype mice after oral allergen challenge.…”

Section: Activation Of An Inhibitory Receptormentioning

confidence: 99%

Mucosal Mast Cells as Key Effector Cells in Food Allergies

Nakano

Kitaura

2022

Cells

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Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in skin and other connective tissues. MMCs are inducible and transient cells that arise from bone marrow-derived mast cell progenitors, and their numbers increase rapidly during mucosal allergic inflammation. However, the mechanism of the dramatic expansion of MMCs and their cell functions are not well understood. Here, we review recent findings on the mechanisms of MMC differentiation and expansion, and we discuss the potential for the inducers of differentiation and expansion to serve as targets for food allergy therapy. In addition, we also discuss the mechanism by which oral immunotherapy, a promising treatment for food allergy patients, induces unresponsiveness to food allergens and the roles of MMCs in this process. Research focusing on MMCs should provide useful information for understanding the underlying mechanisms of food allergies in order to further advance the treatment of food allergies.

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“…In concert with CD103+ CD11b+ DCs, the interaction of the immunoreceptor CD300f and its ligand ceramide was shown to inhibit the development of OVA‐induced food allergy in mice by inhibiting mast cell activation and suppressing Th2 responses. 132 Long‐acting CD300f agonist drugs, such as ceramide, might therefore be promising for preventing and treating food allergy. The tolerogenic potential of naturally present compounds in the human body should also be considered in molecular mechanisms involved in food allergy.…”

Section: Biomarkers In Food Allergy and Anaphylaxismentioning

confidence: 99%

Advances and highlights in biomarkers of allergic diseases

Öğülür

Pat

Ardicli

et al. 2021

Allergy

122

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During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of allergic diseases is characterized by a type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies. The availability of powerful omics technologies, How to cite this article: Ogulur I, Pat Y, Ardicli O, et al. Advances and highlights in biomarkers of allergic diseases.

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CD300f is a potential therapeutic target for the treatment of food allergy

Cited by 20 publications

References 10 publications

Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction

Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction

Mucosal Mast Cells as Key Effector Cells in Food Allergies

Advances and highlights in biomarkers of allergic diseases

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