CD34+ stem cell treatment for knee osteoarthritis: a treatment and rehabilitation algorithm

Abstract

Osteoarthritis of the knee joint is a chronic disease that mainly affects people over 50 years of age. The main symptoms include pain and limitation of range of motion of the joint, which prevent patients from participating in physical activity. Stem cell therapy has been developed in orthopaedics in recent years for the treatment of gonarthrosis. Rehabilitation is necessary after stem cell transplantation in patients with gonarthrosis in order to restore the proper range of joint mobility, for anti-oedematous action, muscle strength improvement, and for elimination of pain. This article describes the physiotherapy algorithm used for patients after stem cell transplantation. Kinesitherapy and physical therapy enabled a more rapid return of the patient to physical or professional activity. Osteoarthritis is a group of multiple overlapping pathological conditions that cause destruction of articular cartilage and other structures of the joint. It is a progressive disease that leads to limitations of physical activity. New forms of treatment are therefore sought to alleviate the clinical symptoms of osteoarthritis and avoid surgery. Stem cell based therapy is an emerging field in orthopaedics. This study describes the treatment of knee osteoarthritis with CD34+ stem cells at the Medical Magnus Outpatient Clinic in Lodz, Poland, together with the treatment and rehabilitation algorithm developed for maximum effectiveness of this procedure. The algorithm includes 3 rehabilitation stages: preoperative, hospitalization and outpatient periods.

Stem cell-based therapy for human diseases

“…To further enhance the therapeutic potential of HSCT, CD34 + stem cells were proposed to be used in combination with the rehabilitation algorithm, which included three stages: preoperative, hospitalization and outpatient periods. 68 Currently, a large wave of studies has been directed to MSC-based therapy for the treatment of OA due to their immunoregulatory functions and anti-inflammatory characteristics. MSCs have been used as the main cell source in several multiple and small-scale trials, proving their safety profile and potential effectiveness in alleviating pain, reducing cartilage degeneration, and enhancing the regeneration of cartilage structure and morphology in some cases.…”

The importance of systematic rehabilitation over 45 years of a patient with developmental dysplasia of the hip joint (case study)

“…Patients are increasingly seeking new and innovative treat- Adres do korespondencji / Corresponding author ments to preserve their joint and avoid endoprosthesis. One such solution is treatment with CD34+ stem cells [10].…”

“…still on the operating table. A specialist team of qualified physiotherapists, together with an original method of a jointly developed algorithm of posttreatment rehabilitation, mobilized to systematic work twice a day, 7 days a week [9,10]. During the first four days after surgery, the patient was strictly forbidden to put any weight on the operated limb, positioning therapy was applied, and light passive exercises were carried out up to the pain limit, together with gentle traction of the hip joint.…”

The Choice of Anticoagulant Influences the Characteristics of Bone Marrow Aspirate Concentrate and Mesenchymal Stem Cell Bioactivity In Vitro

“…However, this logic has recently been contested [10,11]. While the role of other cell types unique to the bone marrow including CD34 + hematopoietic progenitor/ precursor [12] cells and platelets [13] has been proposed as contributors to the therapeutic value of BMC, the value of MSCs in the BMC remains a pinnacle.…”