CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures

Moussa, Myriam; Gouranton, Erwan; Gleize, Béatrice; Yazidi, Claire El; Niot, Isabelle; Besnard, Philippe; Borel, Patrick; Landrier, Jean‐François

doi:10.1002/mnfr.201000399

Cited by 93 publications

(77 citation statements)

References 29 publications

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“…Indeed, we detected lycopene in the adipose tissue (unpublished data). These results are in agreement with FAT/CD36 involvement in the uptake 26 and storage of lycopene 54 in adipose tissue.…”

Section: Discussionsupporting

confidence: 93%

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

et al. 2015

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Aim: To investigate whether lycopene can modulate adiponectin levels and SIRT1 and FoxO1 gene expression in the adipose tissue of diet-induced obese rats. Methods: Male Wistar rats were first fed with hypercaloric diet (HD, n = 12) for 6 weeks, and afterward, these rats were randomly assigned to receive HD ( n = 6) or HD with lycopene-rich tomato oleoresin (equivalent to lycopene 10 mg/kg body weight (BW)/day, HD + L, n = 6) by gavage for additional 6 weeks. Plasma lycopene and adiponectin levels were analyzed by high-performance liquid chromatography and immunoassay, respectively. The messenger RNA (mRNA) expressions of adiponectin, Sirtuin 1 (SIRT1), Forkhead box O 1 (FoxO1), fatty acid translocase/cluster of differentiation 36 (FAT/CD36), and PPARγ in adipose tissues were determined by quantitative polymerase chain reaction. Results: Lycopene was detected in the plasma of rats in HD + L group but not in the HD group. Although both BW and adiposity were not different between the two groups, there was a significant increase in both plasma concentration and mRNA expression of adiponectin in the adipose tissue of the HD + L group. In addition, the lycopene supplementation upregulated mRNA expressions of SIRT1, FoxO1, and FAT/CD36 but downregulated PPARγ in adipose tissue of obese rats. Conclusion: These data suggest that lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications.

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Section: Discussionsupporting

confidence: 93%

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

et al. 2015

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“…Using these two tissues we determined the regulatory pathways by expression analyses of these enzymes / transporters and we tried to associate enzyme / transporter gene expression with the observed RARE-luciferase data. The two carotenoid metabolizing enzymes Bco-1 and Bco-2 may contribute to the lycopene metabolism and the non-specific carotenoid transporter CD36 may contribute to lycopene uptake (Moussa, et al, 2011). However, little is known about the impact of lycopene metabolism and lycopene metabolite induced effects on retinoic acid receptor activation pathways.…”

Section: Discussionmentioning

confidence: 99%

Lycopene induces retinoic acid receptor transcriptional activation in mice

Aydemir

Carlsen

Blomhoff

et al. 2012

Molecular Nutrition Food Res

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Scope Lycopene is a lipophilic carotenoid and provides the red colour to tomatoes and tomato product. Various studies indicated that lycopene and tomatoes/tomato products are able to positively influence various diseases associated with a chronic inflammation. The mechanism of action of lycopene to elicit these effects is partly unknown. A possible mechanism is that biological metabolites of lycopene may activate nuclear hormone receptors in mammalian cells. The aim of this study was to investigate the potential of orally administered lycopene and all‐trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response‐element (RARE)‐reporter mouse system. Methods and results Orally administered lycopene (100 mg/kg bw in beadlets, n = 6) and ATRA as an endogenous RAR ligand (50 mg/kg bw, n = 6) for the induction of the retinoic acid receptor in male mice using a transgenic RARE‐reporter mouse system. Conclusion Lycopene treatments induced RARE‐mediated cell signalling indicated by quantified bioimaging, increased luciferase activity and up‐regulated the retinoid target genes in selected organs of the mice. We conclude that lycopene can induce RAR‐transcriptional activation in mice and lycopene might be a precursor of still non‐identified biologically active metabolites.

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“…The molecular mechanisms involved in VD uptake/ secretion by adipose tissue have not yet been investigated but may well involve the megalin/cubulin pathway (described later) as suggested by Abboud et al (25) and/ or cholesterol transporters as described in the intestine (17) or for other lipophilic micronutrients in adipose tissue (26) . (27) .…”

Section: Uptake Of Vitamin Dmentioning

confidence: 99%

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

et al. 2015

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Cross-sectional studies depict an inverse relationship between vitamin D (VD) status reflected by plasma 25-hydroxy-vitamin D and obesity. Furthermore, recent studies in vitro and in animal models tend to demonstrate an impact of VD and VD receptor on adipose tissue and adipocyte biology, pointing to at least a part-causal role of VD insufficiency in obesity and associated physiopathological disorders such as adipose tissue inflammation and subsequent insulin resistance. However, clinical and genetic studies are far less convincing, with highly contrasted results ruling out solid conclusions for the moment. Nevertheless, prospective studies provide interesting data supporting the hypothesis of a preventive role of VD in onset of obesity. The aim of this review is to summarise the available data on relationships between VD, adipose tissue/adipocyte physiology, and obesity in order to reveal the next key points that need to be addressed before we can gain deeper insight into the controversial VD-obesity relationship.Adipose tissue: Vitamin D: Obesity: Inflammation: Adipocytes: Nutrients: Nutrition Vitamin D: a brief overview Vitamin D (VD; calciferol) is a hormone mainly described for its role as a regulator of phosphate and calcium homeostasis (1) . It can be obtained through animal (VD 3 , cholecalciferol) or plant (VD 2 , ergocalciferol) food sources. Only a few foodstuffs contain significant amounts of VD, the main sources being fish liver oils, fatty fish (sardines, herring and mackerel) and egg yolk (2,3) , but small quantities are also found in fortified milk, orange juice, bread and cereals. Alternatively, VD 3 is produced endogenously in the skin after UVB irradiation from the precursor 7-dehydrocholesterol to give pre-VD 3 , which is further isomerised to VD 3 before being released into the circulation (4) . Classical estimates have assigned a majority (70-90 %) of VD supply to dermal synthesis, but a recent paper revised this figure down to just 10-25 % of VD supply (5) and posited that dietary intake of 25-hydroxy-vitamin D (25(OH)D) is a significant contributor to total VD input.Adipose tissue is a major storage site for vitamin D Despite limited data, it is widely accepted that adipose tissue is a reservoir for VD in human subjects and rats (6)(7)(8)(9)(10) . Interestingly, visceral fat was found to contain 20 % more VD than subcutaneous fat (11) . Heaney et al. (12) calculated that 65 % of total VD in the body is in the form of D 3 , for which adipose tissue and skeletal muscle appear to be the main body stores (accounting for 73 and 16 %, respectively).

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CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures

Abstract: For the first time, we report the involvement of a transporter, CD36, in carotenoid uptake by adipocytes and adipose tissue.

Cited by 93 publications

References 29 publications

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

Lycopene induces retinoic acid receptor transcriptional activation in mice

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

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