CD36 polymorphism, sugary drinks, and sedentarism are associated with hypertriglyceridemic waist phenotype

Abstract

Abstract. Background: The hypertriglyceridemic waist (HTGW) phenotype is characterized by concomitant increases in waist circumference (WC) and blood triglyceride levels (TG), which has been identified as a predictor of metabolic disorders. This study aimed to analyze associations between food consumption, exercise, and the CD36 gene rs1761667 G>A polymorphism with the HTGW phenotype in adult Mexicans. Methods: This cross-sectional study included a total of 255 participants (both genders, between 18–64 years of age). The HTGW phenotype was defined as WC >88 cm in women, WC >102 cm in men, and TG >150 mg/dL. Body composition was analyzed by electrical bioimpedance. Dietary intakes (macro and micronutrients) were evaluated through a validated 64-item food frequency questionnaire and a 24-h recall. Physical exercise was subjectively recorded asking the participants if they regularly performed some systematic exercise or sport of moderate intensity at least 150–300 minutes a week. Biochemical tests were determined by an automated system. A Taqman real-time assay was used to detect the rs1761667 (G>A) polymorphism of the CD36 gene. A multivariate logistic regression model was performed to analyze the variables potentially associated with the HTGW phenotype (adjusted for age, energy intake, and total fat mass). Results: Overall, 21.6% of the population presented the HTGW phenotype; compared to the HTGW−, also, they were older, had more body fat, higher glucose, cholesterol and insulin levels, and high blood pressure. Female sex (OR=2.92, 95% CI: 1.12–7.60, p=0.028), body mass index (OR=1.19, 95% CI: 1.07–1.32, p=0.001), total cholesterol (OR=1.01, 95% CI:1.00–1.02, p=0.039), daily consumption of sugary drinks (OR=6.94, 95% CI: 1.80–26.8, p=0.005), and the CD36 AG genotype (OR=3.81, 95% CI: 1.08–13.4, p=0.037) were positively associated with the HTGW phenotype, while performing exercise played a protective role (OR=0.23, 95% CI: 0.08–0.62, p=0.004). Overall, the model predicted HTGW phenotype in 47% (R2=0.47, p≤0.001). Conclusion: The CD36 AG genotype, daily consumption of sugary drinks and sedentarism are risk factors for HTGW phenotype in Mexicans.

The Interaction between <i>CD36</i> rs1761667 Polymorphism and Dietary Phytochemical Index on the Risk Factors Related to Metabolic Syndrome

“…Previous studies have demonstrated that CD36 polymorphisms are correlated with metabolic dysregulation [49]. Studies about the interaction between CD36 rs1761667 and diet are rare, for example, Navarro-Rios et al [50] showed that daily consumption of sugary drinks can be a risk factor for hypertriglyceridemic waist phenotype (as a predictor of metabolic disorders) in the AG genotype of the rs1761667 polymorphism, while Lopez-Ramos et al [23] observed that individuals with the AA genotype of CD36 rs1761667 had a higher intake of total fat, polyunsaturated fatty acids, MUFA, and saturated fatty acids. Furthermore, the serum cholesterol level in this genotype group was significantly higher than AG genotype carriers.…”

Low Dietary Betaine Intake Is Associated with Increased Blood Cholesterol in Mexican Subjects

“…Additionally, for exercise assessment, participants were asked if they regularly practiced some type of systematic physical exercise or sport (yes/no) at least 150-300 min a week, as described elsewhere [30].…”