2009
DOI: 10.2119/molmed.2008.00108
|View full text |Cite
|
Sign up to set email alerts
|

CD38 and CD157 Ectoenzymes Mark Cell Subsets in the Human Corneal Limbus

Abstract: , and that CD157 is a potential marker of corneal limbal cells in the stem cell niche. The presence and characteristics of these ectoenzymes may be exploited to design drugs for wound repair or for applications in tissue transplantation.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
23
0
1

Year Published

2011
2011
2021
2021

Publication Types

Select...
5
4

Relationship

2
7

Authors

Journals

citations
Cited by 44 publications
(24 citation statements)
references
References 41 publications
0
23
0
1
Order By: Relevance
“…On the other side, the interplay between adenosine and purinergic receptors generates local cellular anergy, which is a relevant mechanism of peripheral tolerance in both normal tissues and in the course of oncogenesis and tumor progression 52 . Therefore, the NAD + -catalytic network that we delineated here is now under evaluation in normal cells (natural killer cells, mesenchymal stem cells, Tregs, regulatory B cells, and myeloid-derived suppressor cells) as well as in the human cornea, which was selected because of its immunologically privileged status and proven expression of CD38 (and CD157) 55 . The results of these studies will indicate whether this adenosinergic ectoenzyme network contributes to the generation of local tolerance or rather facilitates the elicitation of adaptive immune responses.…”
Section: Discussionmentioning
confidence: 99%
“…On the other side, the interplay between adenosine and purinergic receptors generates local cellular anergy, which is a relevant mechanism of peripheral tolerance in both normal tissues and in the course of oncogenesis and tumor progression 52 . Therefore, the NAD + -catalytic network that we delineated here is now under evaluation in normal cells (natural killer cells, mesenchymal stem cells, Tregs, regulatory B cells, and myeloid-derived suppressor cells) as well as in the human cornea, which was selected because of its immunologically privileged status and proven expression of CD38 (and CD157) 55 . The results of these studies will indicate whether this adenosinergic ectoenzyme network contributes to the generation of local tolerance or rather facilitates the elicitation of adaptive immune responses.…”
Section: Discussionmentioning
confidence: 99%
“…These findings indicated that human LSC express p63, however, because of the nuclear expression of p63, further enrichment of the limbal grafts for p63 purity was not feasible, leaving unanswered the question whether a pure p63+ population could have resulted in more universal therapeutic success, as might be expected of an autologous LSC graft. Subsequently, several additional potential human LSC markers were described based on their anatomical and immunohistochemical association with p63, including positive selection markers Lgr5, Tcf4, CD157, CD71 low /Integrin α6 high , TrkA, N‐Cadherin, Abcg2, and Cytokeratin15, and negative selection markers Cytokeratin 3, ALDH dim , RHAMM bright , and Connexin‐43 (Table ).…”
Section: Limbal Stem Cell Identitymentioning
confidence: 99%
“…Many putative corneal epithelial stem cell markers (e.g. p63, ABCG2, Integrin a9, Keratin 15, N-cadherin, NGF/TrkA, Integrin a6/CD71, Hes1, p75, Nectin 3, Importin 13, Nucleostemin, CD38/157, Lrig1, ABCB5, WNT7A) have been reported worldwide (Di Girolamo et al, 2008;Hayashi et al, 2008Hayashi et al, , 2007Horenstein et al, 2009;Kawashima et al, 2009;Ksander et al, 2014;Kusanagi et al, 2009;Nakamura et al, 2014Nakamura et al, , 2008aOuyang et al, 2014;Pajoohesh-Ganji et al, 2006;Pellegrini et al, 2001;Qi et al, 2008;Wang et al, 2009;Watanabe et al, 2004;Yoshida et al, 2006) (Fig. 10).…”
Section: Candidate Limbal Stem Cell Markersmentioning
confidence: 99%