CD4+CD25+CD127low/− T Cells: A More Specific Treg Population in Human Peripheral Blood

Yu, Ning; Li, Xiaomei; Wu, Song; Li, Dongmei; Yu, Daliang; Zeng, Xiaofeng; Li, Mengtao; Leng, Xiaomei; Li, Xiang-Pei

doi:10.1007/s10753-012-9496-8

Cited by 204 publications

(156 citation statements)

References 28 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Conversely, CD127 expression on Treg inversely correlates to Foxp3 expression; therefore, low CD127 expression level is considered a reliable marker of activated Treg. 36 Thus, a general now accepted panel for Treg identification is CTLA-4…”

Section: Regulatory T Cells In Hnscc Developmentmentioning

confidence: 99%

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

Maggioni

Garavello

2017

OncoImmunology

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) is one of the most diffused cancer types, characterized by a high reoccurrence rate, mainly due to the inability of current therapeutic approaches to completely eradicate cancer cells. HNSCC patients often have defective immune functions, thus allowing cancer immune escape and cancer spreading. Particularly important in driving immune escape during HNSCC progression are T-helper and T-regulatory cells. New insights into their mechanisms of action might support the development of effective and long-lasting immunotherapy.

show abstract

Section: Regulatory T Cells In Hnscc Developmentmentioning

confidence: 99%

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

Maggioni

Garavello

2017

OncoImmunology

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated that human peripheral CD4 + CD25 + Tregs can be accurately identified and purified using surface expression of CD127, as an alternative to the transcription factor FOXP3 (38)(39)(40)(41)(42)(43) + Tregs in the current study. A number of therapeutic approaches are aimed at inhibiting immune suppression within the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 68%

Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer

Wang

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Previous studies have reported that regulatory T cells (Tregs), which are physiologically engaged in the maintenance of immunological self-tolerance, have a critical role in the regulation of the antitumor immune response. Targeting Tregs has the potential to augment cancer vaccine approaches. The current study therefore aimed to evaluate the role of cytokine-induced killer (CIK) cell infusion in modulating Tregs in patients with non-small cell lung cancer (NSCLC). A total of 15 patients with advanced NSCLC were treated by an infusion of CIK cells derived from autologous peripheral blood mononuclear cells (PBMCs). By using flow cytometry and liquid chip analysis, subsets of T cells and natural killer (NK) cells in peripheral blood, and plasma cytokine profiles in the treated patients, were analyzed at 2 and 4 weeks after CIK cell infusion. Cytotoxicity of PBMCs (n=15) and NK cells (n=6) isolated from NSCLC patients was evaluated before and after CIK cell therapy. Progression-free survival (PFS) and overall survival (OS) were also assessed. Analysis of the immune cell populations before and after treatment showed a significant increase in NK cells (P<0.05) concomitant with a significant decrease in Tregs (P<0.01) at 2 weeks post-infusion of CIK cells compared with the baseline. NK group 2D receptor (NKG2D) expression on NK cells was also significantly increased at 2 weeks post-infusion compared with the baseline (P<0.05). There was a positive correlation between NKG2D expression and the infusion number of CIK cells (P<0.05).

show abstract

“…21 We defined Tregs using flow cytometry as CD45+CD4+CD25+CD123low, which is reportedly a more specific natural Treg population with suppressor capabilities. 28 Furthermore this is one of the largest studies using a white cohort, and differences in inflammatory cell accumulation in nasal polyps have been reported to be affected by ethnicity. 1,10 To our knowledge this is the first study that has used flow cytometry to examine for resident Th17 cells in the mucosa of CRS patients based on cell surface expression of CD45+CD4+CCR6+.…”

Section: Discussionmentioning

confidence: 95%

T regulatory and Th17 cells in chronic rhinosinusitis with polyps

Miljkovic

Psaltis

Wormald

et al. 2016

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

CD4+CD25+CD127low/− T Cells: A More Specific Treg Population in Human Peripheral Blood

Cited by 204 publications

References 28 publications

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer

T regulatory and Th17 cells in chronic rhinosinusitis with polyps

Contact Info

Product

Resources

About