CD4+, CD25+, FOXP3+ T Regulatory Cell Levels in Obese, Asthmatic, Asthmatic Obese, and Healthy Children

Donma, Mustafa Metın; Karasu, Erkut; Ozdilek, Burcu; Turgut, Burhan; Topçu, Birol; Nalbantoğlu, Burçin; Donma, Orkide

doi:10.1007/s10753-015-0122-4

Cited by 32 publications

(22 citation statements)

References 24 publications

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“…Accordingly, it has been shown that children who were obese, asthmatic, and, asthmatic-obese present significant lower circulating regulatory T cells (Tregs) compared to healthy controls. Tregs have been shown to encourage neutrophil apoptosis, improve efferocytosis, and produce specific cytokines [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Obesity and Asthma: A Missing Link

Gomez-Llorente

Romero

Chueca

et al. 2017

IJMS

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Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of both conditions. The prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second phenotype of later-onset asthma that predominantly affects women. Systemic inflammation and mechanical effect, both due to the expansion of the adipose tissue, have been proposed as the main reasons for the association between obesity and asthma. However, the mechanisms involved are not yet fully understood. Moreover, it has also been suggested that insulin resistance syndrome can have a role in the association between these conditions. The intestinal microbiota is an important factor in the development of the immune system, and can be considered a link between obesity and asthma. In the obese state, higher lipopolysaccharide (LPS) serum levels as a consequence of a microbiota dysbiosis have been found. In addition, changes in microbiota composition result in a modification of carbohydrate fermentation capacity, therefore modifying short chain fatty acid (SCFA) levels. The main objective of this review is to summarize the principal findings that link obesity and asthma.

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Section: Resultsmentioning

confidence: 99%

Obesity and Asthma: A Missing Link

Gomez-Llorente

Romero

Chueca

et al. 2017

IJMS

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“…T cell immunity plays important roles in chronic inflammatory diseases such as obesity. Decreased regulatory T cells status is noted in obese children [3] .…”

Section: Introductionmentioning

confidence: 94%

Beneficial Effects of Poultry Meat Consumption on Cardiovascular Health and the Prevention of Childhood Obesity

2017

Med One

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Poultry meat is an animal product important in human nutrition. A variable, and moderate energy content, highly digestible proteins of good nutritional quality, unsaturated lipids, fat-soluble and B-complex vitamins as well as minerals make poultry meat a valuable food. Poultry meat is one of the recommended constituents of Dietary Approaches to Stop Hypertension Diet as well as the Mediterranean Diet. The substitution of red meat with poultry as well as fish, nuts and legumes decreases the risk of developing type 2 and gestational diabetes mellitus, improves glycemic control and cardiovascular risk factors. Low-fat diets supported by fruits, grains, nuts, fish and poultry instead of red meat yields cardiovascular health benefits. Antiinflammatory and antioxidative diet enriched with high-quality foods reduces pro-inflammatory cytokines. This favors anti-inflammatory milieu which in turn improves insulin sensitivity and endothelial function and ultimately act as a barrier to obesity, metabolic syndrome, type 2 diabetes mellitus and development of atherosclerosis. The nutritive value of poultry meat depends on different factors such as age, feeding, keeping, hybrids, carcass parts and type of meat. Preventive measures against risky aspects of the matter should be developed. Since the use of antibiotics leads to the development of antibiotic resistant pathogens, antibiotics must be replaced by herbs and spices with growth promoting effects, antimicrobial properties, and other health related benefits to solve the problem. Enrichment and fortification with nutrients may cause poultry meat to gain even more functional food character.

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“… 77 78 Concepts of regulatory B cells are being investigated for their role in suppressing T cell-independent activation of B cells with self-reactive B cell receptors (BCRs) 79 and IL-10-mediated regulation of autoimmune responses. 80 In context to asthma, there is evidence of both compromised peripheral tolerance in severe asthmatics with significant low levels of Foxp3 + -Treg cells 81 82 and reduced IL-10 expression. 81 83 Furthermore, CD25 + CTLA4 + Foxp3 + -T cells with regulatory functions were enumerated to be significantly reduced in induced sputum from atopic asthmatics compared to healthy volunteers.…”

Section: Working Hypothesis Of Autoimmune-associated Asthma Pathogenementioning

confidence: 99%

“… 80 In context to asthma, there is evidence of both compromised peripheral tolerance in severe asthmatics with significant low levels of Foxp3 + -Treg cells 81 82 and reduced IL-10 expression. 81 83 Furthermore, CD25 + CTLA4 + Foxp3 + -T cells with regulatory functions were enumerated to be significantly reduced in induced sputum from atopic asthmatics compared to healthy volunteers. 84 Again, none of these studies investigated autoantibodies and therefore neither association nor causality can be derived.…”

Section: Working Hypothesis Of Autoimmune-associated Asthma Pathogenementioning

confidence: 99%

Autoimmune Responses in Severe Asthma

Mukherjee

Nair

2018

Allergy Asthma Immunol Res

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Asthma and autoimmune diseases both result from a dysregulated immune system, and have been conventionally considered to have mutually exclusive pathogenesis. Autoimmunity is believed to be an exaggerated Th1 response, while asthma with a Th2 underpinning is congruent with the well-accepted Th1/Th2 paradigm. The hypothesis of autoimmune involvement in asthma has received much recent interest, particularly in the adult late-onset non-atopic patients (the “intrinsic asthma”). Over the past decades, circulating autoantibodies against diverse self-targets (beta-2-adrenergic receptors, epithelial antigens, nuclear antigens, etc.) have been reported and subsequently dismissed to be epiphenomena resulting from a chronic inflammatory condition, primarily due to lack of evidence of causality/pathomechanism. Recent evidence of ‘granulomas’ in the lung biopsies of severe asthmatics, detection of pathogenic sputum autoantibodies against autologous eosinophil proteins (e.g., eosinophil peroxidase) and inadequate response to monoclonal antibody therapies (e.g., subcutaneous mepolizumab) in patients with evidence of airway autoantibodies suggest that the role of autoimmune mechanisms be revisited. In this review, we have gathered available reports of autoimmune responses in the lungs, reviewed the evidence in the context of immunogenic tissue-response and danger-associated molecular patterns, and constructed the possibility of an autoimmune-associated pathomechanism that may contribute to the severity of asthma.

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CD4+, CD25+, FOXP3+ T Regulatory Cell Levels in Obese, Asthmatic, Asthmatic Obese, and Healthy Children

Cited by 32 publications

References 24 publications

Obesity and Asthma: A Missing Link

Obesity and Asthma: A Missing Link

Beneficial Effects of Poultry Meat Consumption on Cardiovascular Health and the Prevention of Childhood Obesity

Autoimmune Responses in Severe Asthma

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