CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans—impact of immunosenescence

Trzonkowski, Piotr; Szmit, Ewa; Myśliwska, Jolanta; Myśliwski, Andrzej

doi:10.1016/j.clim.2006.02.002

Cited by 132 publications

(88 citation statements)

References 34 publications

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“…62 This suggests that mTOR inhibitors are ideal candidates for short-term immunosuppression therapy after depleting T cells after transplant. 3 It seems that mycophenolate mofetil administration along with mTOR inhibitors favors expansion of the T-regs through induction of tolerogenic dendritic cells 63 and inhibiting expansion of memory T cells. 64 Mycophenolate mofetil increases frequency of T-regs and induces tolerance when combined with vitamin D3.…”

Section: Effects Of Immunosuppressive Drugs On T-regsmentioning

confidence: 99%

“…64 Mycophenolate mofetil increases frequency of T-regs and induces tolerance when combined with vitamin D3. [62][63][64] Preferentially, antithymocyte globulin causes the expansion of T-regs and promotes their function in vivo. 65 The mechanism by which antithymocyte globulin induces expansion of T-regs is conversion of CD4 + CD25 -cells to CD4 + CD25 + cells.…”

Section: Effects Of Immunosuppressive Drugs On T-regsmentioning

confidence: 99%

See 1 more Smart Citation

Regulatory T Cells as a Therapeutic Tool To Induce Solid-Organ Transplant Tolerance: Current Clinical Experiences

Nikoueinejad¹,

Sharif²,

Amirzargar³

et al. 2013

Exp Clin Transplant

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Long-term tolerance is potentially an ideal in organ transplant. Achieving this leads us to eliminate immunosuppressive therapies and their associated side effects. Although most succession in this field belongs to mixed chimerism methods of tolerance induction, regulatory T cells and (T-reg)-based methods also have been demonstrated to prevent organ rejection and lead to transplant tolerance through different mechanisms. In contrast to chimeric protocols (which require bone marrow transplant), T-reg-mediated protocols do not aggressively manipulate blood and the immune system. Most treatment has been done for graft-versus-host disease after hematopoietic stem cell transplant. This review describes different types and mechanisms of action and clinical strategies using T-regs to induce transplant tolerance.

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Section: Effects Of Immunosuppressive Drugs On T-regsmentioning

confidence: 99%

Section: Effects Of Immunosuppressive Drugs On T-regsmentioning

confidence: 99%

Regulatory T Cells as a Therapeutic Tool To Induce Solid-Organ Transplant Tolerance: Current Clinical Experiences

Nikoueinejad¹,

Sharif²,

Amirzargar³

et al. 2013

Exp Clin Transplant

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“…these cells are frequently increased in patients with several types of malignancies and are correlated positively with disease stage and poor prognosis (57). they also play a role in immune evasion mechanisms employed by cancer cells (58), and can decrease the activity of cd8 + t cells and NK cells (59). Further characterisation of the Cd25 + subpopulations was not possible due to the lack of cells for the analysis of T regulatory cell markers such as Foxp3, GITr and cd127.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the Th1/Th2 balance in breast cancer patients using reflexology and scalp massage

Green¹,

Alexandropoulou²,

Walker³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. the diagnosis and treatment of breast cancer can adversely affect quality of life. here the aim was to determine the effects of reflexology on host defences and endocrine function in women with early breast cancer. Six weeks after surgery for early breast cancer, 183 women were randomly assigned to self-initiated support (SIS), SIS plus foot reflexology, or SIS plus scalp massage. peripheral blood mononuclear cells and serum were isolated at T1 (6 weeks post surgery; baseline), T2 and T3 (4 and 10 weeks post completion of intervention, respectively). lymphocyte phenotyping found that cd25 + cells were significantly higher in the massage group compared with the SiS group at t3. the percentage of t cells, and more specifically the T helper subset expressing IL4, decreased significantly in the massage group compared with the SIS group at t3. this change was accompanied by an increase in the percentage of cd8 + T cytotoxic cells expressing IFNγ in the massage group. Natural killer and lymphokine activated killer cell cytotoxicity measurements, serum levels of cortisol, prolactin and growth hormone, and flow cytometric assessment of their corresponding receptors all revealed no significant differences between the three groups of patients. this study provides evidence that the immunological balance of patients can be altered in a potentially beneficial manner by massage. the original trial was registered with the international Standard randomised controlled trial registry (iSrctn87652313).

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“…[10][11][12] There have been some studies pointing to an increase in the proportion of CD25 regulatory T cells in the peripheral blood of aged BALB/c 13,14 and C57BL/6 mice 15,16 as well as in elderly people. [17][18][19][20][21] Such imbalance might contribute to the decreased immune functional activity and other peculiarities of the immune system in this age group. 4,5,[19][20][21][22][23] In addition, increased frequency of the CD4 Foxp3 Treg phenotype has been shown in aged C57BL/6 24 and in elderly people.…”

Section: Abstract: T-lymphocytes Aging Regulators T-lymphocytes Inmentioning

confidence: 99%

“…[17][18][19][20][21] Such imbalance might contribute to the decreased immune functional activity and other peculiarities of the immune system in this age group. 4,5,[19][20][21][22][23] In addition, increased frequency of the CD4 Foxp3 Treg phenotype has been shown in aged C57BL/6 24 and in elderly people. 25 In contrast, more recent studies have found normal CD4 Foxp3 Treg cell frequency in elderly people.…”

Section: Abstract: T-lymphocytes Aging Regulators T-lymphocytes Inmentioning

confidence: 99%

Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women

Cruvinel

Júnior

Araújo

et al. 2015

Rev. Assoc. Med. Bras.

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CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans—impact of immunosenescence

Cited by 132 publications

References 34 publications

Regulatory T Cells as a Therapeutic Tool To Induce Solid-Organ Transplant Tolerance: Current Clinical Experiences

Regulatory T Cells as a Therapeutic Tool To Induce Solid-Organ Transplant Tolerance: Current Clinical Experiences

Alterations in the Th1/Th2 balance in breast cancer patients using reflexology and scalp massage

Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women

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