CD4+/CD8+ Ratio and Growth Differentiation Factor 8 Levels in Peripheral Blood of Large Canine Males Are Useful Parameters to Build an Age Prediction Model

Lee, Han-Jun; Hong, Seok-Jin; Kim, Seung Soo; Kwon, Young-Yon; Choi, Bong Hwan; Choi, Kyung Il; Sheen, S; Lee, Myung-jin; Hwang, Sun‐Young; Park, Kyoungwan; Joo, Y C; Song, H M; Lee, Cheol Koo

doi:10.5534/wjmh.210003

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…This unavoidable thymus involution is regarded as one of the main factors contributing to the loss of immune function typical of the elderly and is considered in turn a genetically programmed event (the so-called “thymus clock”) [ 15 , 17 , 21 , 29 ]. In a recent study (2022), Lee et al proposed both CD4/CD8 ratio and Growth Differentiation Factor 8 (GDF8) levels in canine blood as useful factors to use as an age prediction model for dogs, as these parameters were found to be significantly correlated with age [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Aging on the Immune Response to Core Vaccines in Senior and Geriatric Dogs

Dall’Ara

Lauzi

Turin

et al. 2023

Veterinary Sciences

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Elderly dogs are steadily increasing worldwide as well as veterinarians’ and owners’ interest in their health and wellness. Aging is not a disease, but a combination of changes negatively affecting the organism in general and the immune system in particular, resulting in a decline in protection over time. The aim of this study was to measure the specific serum antibody titers against the main dangerous and widespread viral diseases preventable by core vaccinations in senior and geriatric dogs using the in-practice test VacciCheck. A cohort of three hundred fifty elderly dogs was analyzed for Protective Antibody Titers (PATs) against CPV-2, CDV and CAdV-1. The age ranged from 5 to 19 years, with two hundred fifty-eight seniors (73.7%) and ninety-two geriatrics (26.3%), and 97.4% of them were vaccinated at least once in their lives. More than half of the entire study population (52.9%) had PATs simultaneously for all three diseases, with 80.5% seniors and 19.5% geriatrics. Specific PATs were found in 88.6% of aging dogs for CPV-2, 82.3% for CadV-1 and 66.0% for CDV, demonstrating that unprotected aging dogs represent a minority. Unexpectedly, the larger elderly dogs resulted as more protected than smaller ones for CPV-2. Protection then decreases over time, with geriatric dogs less protected than senior ones. Veterinary practitioners should therefore always consider whether to maintain core vaccinations in aging dogs as in adults on a three-year basis or opt instead for closer boosters (every 1 or 2 years). PATs for core vaccines could then represent a good biomarker of protection and their titration could become a standard of care, especially in such a sensitive period of the dogs’ life.

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Section: Introductionmentioning

confidence: 99%

Effect of Aging on the Immune Response to Core Vaccines in Senior and Geriatric Dogs

Dall’Ara

Lauzi

Turin

et al. 2023

Veterinary Sciences

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Comprehensive multi-omics integration uncovers mitochondrial gene signatures for prognosis and personalized therapy in lung adenocarcinoma

Zhang,

Zhao,

Zheng

et al. 2024

J Transl Med

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The therapeutic efficacy of lung adenocarcinoma (LUAD), the most prevalent histological subtype of primary lung cancer, remains inadequate, with accurate prognostic assessment posing significant challenges. This study sought to elucidate the prognostic significance of mitochondrial-related genes in LUAD through an integrative multi-omics approach, aimed at developing personalized therapeutic strategies. Utilizing transcriptomic and single-cell RNA sequencing (scRNA-seq) data, alongside clinical information from publicly available databases, we first applied dimensionality reduction and clustering techniques to the LUAD single-cell dataset, focusing on the subclassification of fibroblasts, epithelial cells, and T cells. Mitochondrial-related prognostic genes were subsequently identified using TCGA-LUAD data, and LUAD cases were stratified into distinct molecular subtypes through consensus clustering, allowing for the exploration of gene expression profiles and clinical feature distributions across subtypes. By leveraging an ensemble of machine learning algorithms, we developed an Artificial Intelligence-Derived Prognostic Signature (AIDPS) model based on mitochondrial-related genes and validated its prognostic accuracy across multiple independent datasets. The AIDPS model demonstrated robust predictive power for LUAD patient outcomes, revealing significant differences in responses to immunotherapy and chemotherapy, as well as survival outcomes between risk groups. Furthermore, we conducted comprehensive analyses of tumor mutation burden (TMB), immune microenvironment characteristics, and genome-wide association study (GWAS) data, providing additional insights into the mechanistic roles of mitochondrial-related genes in LUAD pathogenesis. This study not only offers a novel approach to improving prognostic assessments in LUAD but also establishes a strong foundation for the development of personalized therapeutic interventions. Supplementary Information The online version contains supplementary material available at10.1186/s12967-024-05754-y.

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A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs

Wambacq,

Apper,

Le Bourgot

et al. 2024

Front. Vet. Sci.

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IntroductionElderly dogs often suffer from chronic diseases, in part attributed to immunosenescence, characterized by reduced blood CD4+ T cells (helper T cells) and elevation in the CD8+ T cells subset (cytotoxic T cells). Studies conducted in adult dogs suggested that supplementing short chain fructo-oligosaccharides (scFOS) or postbiotics derived from yeasts may positively influence the immune response. The aim of the current study was to investigate whether dietary supplementation with a combination of scFOS with a new yeast postbiotic (Profeed ADVANCED® called scFOS+) could have a positive influence on the immune status of senior dogs subjected to an immune challenge (Lyme disease vaccination).MethodsTo this end, 22 healthy senior client-owned dogs were divided into two groups: one group received a placebo diet without scFOS+ and the other group the basal diet supplemented with 1.1% scFOS+. In order to assess immune function, complete blood count, serum acute phase proteins, immunoglobulins, cytokines, T-cell subsets and antibody secreting cells were analyzed. Furthermore, faecal score and pH were recorded.Results and discussionDogs fed the scFOS+ supplement had decreased total serum IgA concentrations (p < 0.01), which might suggest a more local IgA response in agreement with what was previously found when adult dogs were supplemented with β-1, 3/1, 6-glucan, a yeast-based product. More importantly, the present study demonstrated that feeding 1.1% scFOS+ to healthy senior dogs increased the CD4+:CD8+ T-cell (Helper:Cytotoxic T cell) ratio (p < 0.001) during and after vaccination against Lyme disease. Combining scFOS and yeast-derived postbiotics in the diet can therefore counter certain characteristics of T-cell immunosenescence in dogs.

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CD4+/CD8+ Ratio and Growth Differentiation Factor 8 Levels in Peripheral Blood of Large Canine Males Are Useful Parameters to Build an Age Prediction Model

Cited by 3 publications

References 53 publications

Effect of Aging on the Immune Response to Core Vaccines in Senior and Geriatric Dogs

Effect of Aging on the Immune Response to Core Vaccines in Senior and Geriatric Dogs

Comprehensive multi-omics integration uncovers mitochondrial gene signatures for prognosis and personalized therapy in lung adenocarcinoma

A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs

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