1998
DOI: 10.1097/00007890-199805150-00022
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Cd4 Lymphocytopenia as a Risk Factor for Skin Cancers in Renal Transplant Recipients

Abstract: CD4 cell depletion is associated with skin cancer in long-term renal transplant recipients.

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Cited by 118 publications
(71 citation statements)
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“…The influence of CD4 T cell lymphopenia on survival persisted even after return to dialysis and immunosuppressive withdrawal. We previously reported that RTRs with persistent CD4 T cell lymphopenia have an increased risk for opportunistic infections, 6 cancer, 7,8 and atherosclerotic disease. 9 Our results here add to the clinical impact of immune reconstitution after ATG administration in RTRs and underlines the need for both pretransplantation recognition of patients who are at risk for impaired immune reconstitution and posttransplantation monitoring of CD4 T cell after ATG administration to guide preventive measures.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The influence of CD4 T cell lymphopenia on survival persisted even after return to dialysis and immunosuppressive withdrawal. We previously reported that RTRs with persistent CD4 T cell lymphopenia have an increased risk for opportunistic infections, 6 cancer, 7,8 and atherosclerotic disease. 9 Our results here add to the clinical impact of immune reconstitution after ATG administration in RTRs and underlines the need for both pretransplantation recognition of patients who are at risk for impaired immune reconstitution and posttransplantation monitoring of CD4 T cell after ATG administration to guide preventive measures.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, renal transplant recipients (RTRs) with persistent CD4 T cell lymphopenia exhibit a higher rate of late opportunistic infections 6 and an increased incidence of cancers. 7,8 More recently, we reported an increased rate of atherosclerotic events (AEs) in patients with impaired CD4 T cell reconstitution. 9 Nevertheless, whether impaired immune reconstitution after ATG influences patient survival remains to be determined.…”
mentioning
confidence: 99%
“…Currently available immunosuppression therapies have little impact in this process. Furthermore, as they lack specificity, protective anti-infectious and anticancer immune responses are also suppressed, resulting in higher rates of infection and cancer in allograft recipients [1]. Thus, a yet still elusive aim is to induce immune tolerance to donor allograft.…”
Section: Introductionmentioning
confidence: 99%
“…Increased age, longer duration of immunosuppression, more intense immunosuppression, more extensive UV radiation exposure, presence of human papillomavirus (HPV) infection, easily burned skin, and CD4 lymphocytopenia are associated with an increased risk for skin cancer. [10][11][12] Conversely, sex of the recipient, cadaveric versus live donor transplant, repeated transplantation, administration of antithymocyte globulin or OKT3, and duration of dialysis do not appear to confer an increased cancer risk. 11 The relative risk of HLA-B mismatch and HLA recipient antigens remains controversial.…”
Section: Skin Cancer In Organ Transplant Recipientsmentioning
confidence: 99%