2018
DOI: 10.1089/aid.2018.0105
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CD4+T Cell Subsets and Pathways to HIV Latency

Abstract: Latent infection of CD4 T cells is the main barrier to eradicating HIV-1 infection from infected patients. The cellular and molecular mechanisms involved in the establishment and maintenance of latent infection are directly linked to the transcriptional program of the different CD4 T cell subsets targeted by the virus. In this review, we provide an overview of how T cell activation, T cell differentiation into functional subsets, and the mode of initial viral infection influence HIV proviral transcription and … Show more

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Cited by 22 publications
(22 citation statements)
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“…With the progress of the disease, despite the efforts of T cells to ght against the virus, CD4, CD8 and other lymphocytes are reduced in severe patients or in the later stage of the disease due to the virulence of the virus or the decline of the body's immunity. Possible, the mechanism is similar to that of CD4 cell reduction caused by HIV [26,27]. These results re ect the body reach the maximum to clear the virus, so that this stage may result in decreased lung function, liver function, kidney function, and even blood clotting and heart function.…”
Section: Discussionmentioning
confidence: 67%
“…With the progress of the disease, despite the efforts of T cells to ght against the virus, CD4, CD8 and other lymphocytes are reduced in severe patients or in the later stage of the disease due to the virulence of the virus or the decline of the body's immunity. Possible, the mechanism is similar to that of CD4 cell reduction caused by HIV [26,27]. These results re ect the body reach the maximum to clear the virus, so that this stage may result in decreased lung function, liver function, kidney function, and even blood clotting and heart function.…”
Section: Discussionmentioning
confidence: 67%
“…With the progress of the disease, despite the efforts of T cells to ght against the virus, CD4, CD8 and other lymphocytes were reduced in severe patients or in the later stage of the disease due to the virulence of the virus or the decline of the body's immunity. Possible, the mechanism was similar to that of CD4 cell reduction caused by HIV [26,27].…”
Section: Discussionmentioning
confidence: 71%
“…With the progress of the disease, despite the efforts of T cells, CD4, CD8 and other lymphocytes were reduced in severe patients or in the later stage of the disease owing to the virulence of the virus or the decline of the body's immunity. Whether the mechanism is similar to that of HIV causing CD4 cell depletion remains to be investigated [24,25]. These results re ect the body reached the maximum for clearing the virus, so that this stage may result in decreased lung function, liver function, kidney function, heart function, and even blood clotting.…”
Section: Discussionmentioning
confidence: 99%