CD4+ T lymphocytes produce adiponectin in response to transplants

Danturti, Sreedevi; Keslar, Karen; Steinhoff, Leah R.; Fan, Ran; Dvorina, Nina; Valujskikh, Anna; Fairchild, Robert L.; Baldwin, William M.

doi:10.1172/jci.insight.89641

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…At present, adipokines are regarded as the main players in the interactions between adipose tissues and the immune system (Procaccini et al, 2013 ; Hutcheson, 2015 ; Abella et al, 2017 ). Adipokines can modulate the inflammatory and immune response, and a normal function of adipose tissues is thus critical for maintaining immune tolerance in human bodies (Lourenco et al, 2016 ; Abella et al, 2017 ; Danturti et al, 2017 ). The critical roles of adipokines in modulating immune function provide some explanations for the relationship between obesity and TAI.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Associations of Obesity With Hypothyroidism and Thyroid Autoimmunity Among Chinese Adults

Wang

Song

et al. 2018

Front. Physiol.

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There is an intensive link between obesity and thyroid dysfunction, but this relationship in Asians is still unclear. This study was conducted to define the impact of obesity on risk of hypothyroidism and thyroid autoimmunity among Chinese adults. A population-based, cross-sectional study was carried out, which enrolled a total of 2,808 Chinese adults. To assess the associations of obesity with hypothyroidism and thyroid autoimmunity, odds ratio (ORs) with 95% confidence intervals (95%CIs) were calculated through logistic regression model, and the correlations of body mass index (BMI) with TPOAb and TGAb were also analyzed. Obese females had higher risk of hypothyroidism (22.7 vs. 15.0%; OR = 1.66, 95%CI 1.10–2.53; P = 0.02) and higher risk of subclinical hypothyroidism (22.1 vs. 13.4%; OR = 1.83, 95%CI 1.20–2.80; P = 0.005) than non-obese females. Multivariate logistic regression analysis found significant associations of obesity with hypothyroidism (Adjusted OR = 1.54, 95%CI 1.00–2.38; P = 0.05) and subclinical hypothyroidism (Adjusted OR = 1.69, 95%CI 1.09–2.63; P = 0.02) in females after adjustment for confounding factors. No association between obesity and hypothyroidism was observed in male participants. Spearman's correlation analysis suggested BMI was significantly and positively correlated with TPOAb (Spearman's r = 0.062, P = 0.022) in men but not in women. Linear regression analysis suggested an obviously positive correlation of BMI with TPOAb in men (β = 0.018, P = 0.015) and an obviously negative correlation of BMI with TGAb in women (β = −0.025, P = 0.012), respectively. The study suggests sex differences in the associations of obesity with hypothyroidism and thyroid autoimmunity among Chinese adults. Further studies are needed to better understand the exact mechanism of sex difference in the obesity-thyroid relationship.

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Section: Discussionmentioning

confidence: 99%

Sex Differences in the Associations of Obesity With Hypothyroidism and Thyroid Autoimmunity Among Chinese Adults

Wang

Song

et al. 2018

Front. Physiol.

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“…Further experiments indicated that adipocyte-derived adiponectin was responsible for the reduction in the IFN-γ and IL-17-producing T lymphocytes in mice fed a normal diet [120]. More recently it was demonstrated in murine cardiac transplant studies that CD4 + T cells are also an important local source of adiponectin in the transplanted heart [121]. Comparatively, less is known about the effect of adiponectin on B cells.…”

Section: Adiponectin and Immune Functionmentioning

confidence: 99%

The complex role of adipokines in obesity, inflammation, and autoimmunity

2021

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The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since the discovery of leptin in 1994, a multitude of studies have characterized the pathological changes that occur within adipose tissue in the obese state. One significant change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge on adipokine structure and physiological function, and focus on the known roles of these factors in the modulation of the immune response. I will also discuss adipokines in rheumatic and autoimmune diseases.

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“…We speculate that CD4 + T cells found in the choroid plexus influence (either by direct contact or indirectly by secreting factors) the transport of molecules through the choroid plexus epithelium than can then reach the CSF and the brain parenchyma. Some factors produced by CD4 + T cells in EE such as cytokines or chemokines, or adiponectin, which has been shown to be produced by these cells in under certain conditions ( Crawford et al, 2010 ; Danturti et al, 2017 ), could favor brain plasticity ( Nicolas et al, 2015 ; Zhang et al, 2016 ). In this line, we found that genes encoding for CXCR6, IFNγ and CCL5 were upregulated in CD4 + T cells from choroid plexus of EE mice relative to SE mice.…”

Section: Discussionmentioning

confidence: 99%

CD4+ T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity

Zarif¹,

Hosseiny²,

Paquet³

et al. 2018

Front. Synaptic Neurosci.

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Living in an enriched environment (EE) benefits health by acting synergistically on various biological systems including the immune and the central nervous systems. The dialog between the brain and the immune cells has recently gained interest and is thought to play a pivotal role in beneficial effects of EE. Recent studies show that T lymphocytes have an important role in hippocampal plasticity, learning, and memory, although the precise mechanisms by which they act on the brain remain elusive. Using a mouse model of EE, we show here that CD4+ T cells are essential for spinogenesis and glutamatergic synaptic function in the CA of the hippocampus. However, CD4+ lymphocytes do not influence EE-induced neurogenesis in the DG of the hippocampus, by contrast to what we previously demonstrated for CD8+ T cells. Importantly, CD4+ T cells located in the choroid plexus have a specific transcriptomic signature as a function of the living environment. Our study highlights the contribution of CD4+ T cells in the brain plasticity and function.

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CD4+ T lymphocytes produce adiponectin in response to transplants

Cited by 6 publications

References 24 publications

Sex Differences in the Associations of Obesity With Hypothyroidism and Thyroid Autoimmunity Among Chinese Adults

Sex Differences in the Associations of Obesity With Hypothyroidism and Thyroid Autoimmunity Among Chinese Adults

The complex role of adipokines in obesity, inflammation, and autoimmunity

CD4+ T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity

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