2016
DOI: 10.21873/anticanres.10991
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CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis

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Cited by 21 publications
(14 citation statements)
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“…Findings on CD40 are consistent with the results published by Keidai et al, in which 51.9% of NSCLC tissue specimens [24] and 78% of lung cancer cell lines (14 of 18) expressed CD40 [25]. Furthermore, the expression of CD40 has been documented in many other carcinomas, such as melanomas [26], hepatocellular carcinomas [27] thyroid [28], bladder [29], colon [30], esophageal squamous cell [31], ovarian [32], gastric [33], cervical [34], breast and pancreatic cancer [35], as well as in the vast majority of hematological malignancies [36,37].…”
Section: Discussionsupporting
confidence: 89%
“…Findings on CD40 are consistent with the results published by Keidai et al, in which 51.9% of NSCLC tissue specimens [24] and 78% of lung cancer cell lines (14 of 18) expressed CD40 [25]. Furthermore, the expression of CD40 has been documented in many other carcinomas, such as melanomas [26], hepatocellular carcinomas [27] thyroid [28], bladder [29], colon [30], esophageal squamous cell [31], ovarian [32], gastric [33], cervical [34], breast and pancreatic cancer [35], as well as in the vast majority of hematological malignancies [36,37].…”
Section: Discussionsupporting
confidence: 89%
“…Furthermore, CD40-CD40L interaction can affect the growth regulation of some tumors. Matsumura et al, proposed that the expression of CD40 is associated with progression of ESCC [23]. Moreover, as one of the apoptosis-related markers, FasL plays an important role in the development of ESCC [24].…”
Section: Discussionmentioning
confidence: 99%
“…Substantial CD40 expression was detected in a variety of frequent solid cancer types including bladder cancer (102/131, 78%), melanoma (41/71, 57,7%), breast cancer (53%), lung cancer (67/129, 51,9%), colon cancer (87/110, 79%) as well as B-lineage malignancies 14–19. CD40 expression was frequently shown to be associated with prolonged survival; however, contrary results were evident in lung and oesophageal cancer as CD40 expression correlated with poor prognosis 17 20. Interestingly, compared with cancer tissue, normal tissues exhibited very low to no CD40 levels, underscoring the potential of CD40 as a cancer-specific immunological target.…”
Section: Cd40 Expression and Signalling In Cancermentioning
confidence: 99%