CD44 (CD44 molecule (Indian blood group))

Sen, Yin-Ping; Yip, George

doi:10.4267/2042/44676

Cited by 3 publications

(6 citation statements)

References 47 publications

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“…CD44 encompasses 20 exons spanning a length of 60 kb, with the first five exons (Exons 1-5) and the last 5 exons (Exons 1-9) being conserved in all the isoforms; they encode the N-terminal (extracellular) and C-terminal (extracellular, transmembrane and, cytoplasmic) domains, respectively for all CD44 isoforms 11 . The remaining 10 intermediate exons (Exons 5a-14; v1-v10) can be involved in alternative splicing, thus generating several CD44 variants (Figure 1 ) .…”

Section: Structure Of Cd44mentioning

confidence: 99%

“…Post-translational modifications with N-glycosylation, O-glycosylation and glycosaminoglycannation by heparan sulphate or chondroitin sulphate results in the generation of multiple isoforms (at least 20 are identified) of variable molecular sizes (85-230 kDa), suggesting the involvement of CD44 in various cellular processes 11 , 12 .…”

Section: Structure Of Cd44mentioning

confidence: 99%

“…The non-variant standard form of CD44, CD44s, also known, as hematopoietic CD44 (CD44H) is the smallest molecule (85-95kDa), encoded by the conserved exons and is the highly expressed CD44 isoform, and is present on the surface of most vertebrate cells 8 . It is a single-chain molecule consisting of various domains; distal extracellular domain (N-terminal) comprising ligand-binding sites, a membrane-proximal region, transmembrane domain and, a cytoplasmic domain (Figure 2 ) 11 .…”

Section: Structure Of Cd44mentioning

confidence: 99%

“…Moreover, these variants have tissue-specific expression, regulated by different environment and tissue-specific factors, as well as oncogenic pathways, particularly the Ras-MAPK pathways that control alternative splicing during cancer progression 12 , 13 While CD44 lacking v2-v10 is the most common form on hematopoietic cells; larger CD44 splice variants are present on normal and neoplastic epithelia, activated lymphocytes and malignant lymphomas 13 . CD44v8-10 (CD44E) is frequently dominant on epithelial cells, while the longest CD44 isoform, CD33v3-10, expressing eight exons of the variable region is present in keratinocytes 11 .…”

Section: Structure Of Cd44mentioning

confidence: 99%

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Novel CD44-downstream signaling pathways mediating breast tumor invasion

et al. 2018

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CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including PI3K/AKT, Rho GTPases and the Ras-MAPK pathways, but also acts as a growth/arrest sensor, and inhibitor of angiogenesis and invasion, in response to signals from the microenvironment. The function of CD44 has been very controversial since it acts as both, a suppressor and a promoter of tumor growth and progression. To address this discrepancy, we have previously established CD44-inducible system both in vitro and in vivo. Next, using microarray analysis, we have identified and validated Survivin, Cortactin and TGF-β2 as novel CD44-downstream target genes, and characterized their signaling pathways underpinning CD44-promoted breast cancer (BC) cell invasion. This report aims to update the literature by adding and discussing the impact of these novel three signaling pathways to better understand the CD44-signaling pathways involved in BC tumor cell invasion.

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Section: Structure Of Cd44mentioning

confidence: 99%

Section: Structure Of Cd44mentioning

confidence: 99%

Section: Structure Of Cd44mentioning

confidence: 99%

Section: Structure Of Cd44mentioning

confidence: 99%

See 2 more Smart Citations

Novel CD44-downstream signaling pathways mediating breast tumor invasion

et al. 2018

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“…CD44 is a membrane receptor which plays a role in cell adhesion (cell-cell and cell-extracellular matrix interactions), cell traffic, presentation of chemokines and growth factors, signals transmission. High levels of expression of CD44 have been observed in a high number of cancer types, including non-Hodgkin Lymphomas (Sen and Yip 2010).…”

Section: Cd44mentioning

confidence: 99%

t(11;14)(p13;q32) IGH/CD44

Huret¹

2019

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Targeting CD44 Receptor Pathways in Degenerative Joint Diseases: Involvement of Proteoglycan-4 (PRG4)

Qadri

2023

Pharmaceuticals

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Rheumatoid arthritis (RA), osteoarthritis (OA), and gout are the most prevalent degenerative joint diseases (DJDs). The pathogenesis underlying joint disease in DJDs remains unclear. Considering the severe toxicities reported with anti-inflammatory and disease-modifying agents, there is a clear need to develop new treatments that are specific in their effect while not being associated with significant toxicities. A key feature in the development of joint disease is the overexpression of adhesion molecules, e.g., CD44. Expression of CD44 and its variants in the synovial tissues of patients with DJDs is strongly associated with cartilage damage and appears to be a predicting factor of synovial inflammation in DJDs. Targeting CD44 and its downstream signaling proteins has emerged as a promising therapeutic strategy. PRG4 is a mucinous glycoprotein that binds to the CD44 receptor and is physiologically involved in joint lubrication. PRG4-CD44 is a pivotal regulator of synovial lining cell hemostasis in the joint, where lack of PRG4 expression triggers chronic inflammation and fibrosis, driven by persistent activation of synovial cells. In view of the significance of CD44 in DJD pathogenesis and the potential biological role for PRG4, this review aims to summarize the involvement of PRG4-CD44 signaling in controlling synovitis, synovial hypertrophy, and tissue fibrosis in DJDs.

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CD44 (CD44 molecule (Indian blood group))

Abstract: This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.

Cited by 3 publications

References 47 publications

Novel CD44-downstream signaling pathways mediating breast tumor invasion

Novel CD44-downstream signaling pathways mediating breast tumor invasion

t(11;14)(p13;q32) IGH/CD44

Targeting CD44 Receptor Pathways in Degenerative Joint Diseases: Involvement of Proteoglycan-4 (PRG4)

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