CD44 Expression in Dysplastic and Non-Dysplastic Oral Lichen Planus

Ghazi, Narges; Saghravanian, Nasrollah; Ghazi, Ala; Shakeri, Mohammad Taghi; Khajehbahrami, Hamidreza

doi:10.5812/ijcm.98061

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…CD44 has been known to participate in the extravasation of lymphocytes to inflammatory areas ( 40 ). Earlier studies also observed increased expression of CD44 ( 41 ), LFA-1 (encoded by ITGB2 ) ( 42 ) in OLP lesions compared with healthy oral mucosa by immunohistochemistry. A recent study reported that IFN-γ could enhance the motility and cytotoxicity of CD8 T cells ( 43 ).…”

Section: Discussionmentioning

confidence: 69%

Single-cell immune profiling reveals immune responses in oral lichen planus

Wang

Shi

et al. 2023

Front. Immunol.

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IntroductionOral lichen planus (OLP) is a common chronic inflammatory disorder of the oral mucosa with an unclear etiology. Several types of immune cells are involved in the pathogenesis of OLP.MethodsWe used single-cell RNA sequencing and immune repertoire sequencing to characterize the mucosal immune microenvironment of OLP. The presence of tissue-resident memory CD8+ T cells are validated by multiplex immunofluorescence.ResultsWe generated a transcriptome atlas from four OLP biopsy samples and their paired peripheral blood mononuclear cells (PBMCs), and compared them with two healthy tissues and three healthy PBMCs samples. Our analysis revealed activated tissue-resident memory CD8+ T cells in OLP tissues. T cell receptor repertoires displayed apperant clonal expansion and preferrential gene pairing in OLP patients. Additionally, obvious BCR clonal expansion was observed in OLP lesions. Plasmacytoid dendritic cells, a subtype that can promote dendritic cell maturation and enhance lymphocyte cytotoxicity, were identified in OLP. Conventional dendritic cells and macrophages are also found to exhibit pro-inflammatory activity in OLP. Cell-cell communication analysis reveals that fibroblasts might promote the recruitment and extravasation of immune cells into connective tissue.DiscussionOur study provides insights into the immune ecosystem of OLP, serving as a valuable resource for precision diagnosis and therapy of OLP.

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Section: Discussionmentioning

confidence: 69%

Single-cell immune profiling reveals immune responses in oral lichen planus

Wang

Shi

et al. 2023

Front. Immunol.

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“…This marker along with its ligand, hyaluronan is involved in various inflammatory diseases, including OLP. Investigating the role and functional mechanism of CD44 can serve as a therapeutic goal in chronic inflammatory diseases (16). Previous studies have shown that increased CD44 is associated with a worse outcome including metastasis and relapse in the colon, gastric, breast, and osteosarcoma cancers (7).…”

Section: Discussionmentioning

confidence: 99%

Literature review of cancer stem cells in oral lichen planus: a premalignant lesion

Moosavi¹,

Tavakol²

2021

Stem Cell Investig

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Objective: As there is no review study about cancer stem cells (CSCs) involved in the pathogenesis of oral lichen planus (OLP), for the first time we review the role of these cells in OLP and this hypothesis may be a clue for the evaluation of the premalignancy of OLP.Background: Cellular mediated immune responses are the main etiopathogenesis in OLP and it is a potentially premalignant lesion. One of the factors proposed in the pathogenesis of OLP and the comparable trend of this autoimmune disease to squamous cell carcinoma (SCC) are CSCs. CSCs have been detected in several solid tumors including head and neck cancers, and have special characteristics including metastasis and resistance to chemotherapy.Methods: Related keywords were searched and risk of bias assessment was done for each study.Conclusions: Among all of the studies reviewed in this article, all markers had increased expression in OLP compared to controls that are consistent with SCC. Only CD44 was in contradiction to other papers, in which different expression of CD44 strains was measured in different samples such as saliva and tissue.Based on the results of this review and more studies in the future by investigating the levels of these markers in OLP, it may be possible to determine the prognosis and course of the disease for each patient individually.

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“…Severe epithelial dysplasia cases showed down-regulated CD44 expression. One of the latest studies by Ghazi et al [90] analyzed CD44 expression in dysplastic and non-dysplastic oral lichen planus (OLP) tissue. The WHO has classified OLP as a potentially malignant oral lesion, as various data have shown a rather wide range of malignant transformation rates (0-12.5%).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues

Čēma

Dzudzilo

Kleina

et al. 2021

Cancers

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The aim of this study was to determine whether and how pan-CD44 protein expression in leukoplakia tissues correlates with positive SolCD44 test presence and their role in oral leukoplakia. SolCD44 and total protein expression in saliva were determined using an OncAlert® Oral Cancer Rapid test. Comparison of paired associations of total protein, SolCD44, mean number of CD44 expressed epithelial layers in leukoplakia tissue, and macrophages below the basement membrane between control group and patients with leukoplakia showed statistically significant results (p < 0.0001). It is shown that the total protein indicates low or elevated risk of possible malignant transformation processes in leukoplakia. Statistically significant differences between higher total protein level and clinical forms of oral leukoplakia (p < 0.0001), as well as CD44-labeled epithelial cell layer decrease (p < 0.0001), were found. This possibly points to the onset of the stemness loss in leukoplakia tissue. CD9 antigen expression in the exosomes of the oral epithelium explained the intercellular flow of SolCD44 and other fluids in the leukoplakia area. We conclude that the OncAlert® Oral Cancer Rapid test is a valuable screening method in daily clinical practice, in terms of complementing clinical diagnostics methods and to assess the potential for early malignancy.

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CD44 Expression in Dysplastic and Non-Dysplastic Oral Lichen Planus

Cited by 9 publications

References 19 publications

Single-cell immune profiling reveals immune responses in oral lichen planus

Single-cell immune profiling reveals immune responses in oral lichen planus

Literature review of cancer stem cells in oral lichen planus: a premalignant lesion

Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues

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