2010
DOI: 10.1158/1078-0432.ccr-10-0799
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CD44 Expression Predicts Local Recurrence after Radiotherapy in Larynx Cancer

Abstract: Purpose: To find molecular markers from expression profiling data to predict recurrence of laryngeal cancer after radiotherapy.Experimental Design: We generated gene expression data on pre-treatment biopsies from 52 larynx cancer patients. Patients developing a local recurrence were matched for T-stage, subsite, treatment, gender and age with non-recurrence patients. Candidate genes were then tested by immunohistochemistry on tumor material from a second series of 76 patients. Both series comprised early stage… Show more

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Cited by 158 publications
(118 citation statements)
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“…These results are in line with data regarding the putative CSC marker CD44, which has been shown to be functionally relevant for the tumorigenicity of colorectal cancer cells (17). CD44 expression was shown to correlate with in vitro plating efficiency in laryngeal cancer cell lines and in patients with early laryngeal cancer with local tumor control after radiotherapy (18). Of interest, in this dataset, no correlation was observed between the in vitro intrinsic radiosensitivity of the cell lines and CD44 expression, suggesting a possibly higher impact of the number of CSCs or clonogens compared with their intrinsic radioresistance for local tumor control.…”
Section: Radioresistance Of Tumors Is Mediated By Cscssupporting
confidence: 87%
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“…These results are in line with data regarding the putative CSC marker CD44, which has been shown to be functionally relevant for the tumorigenicity of colorectal cancer cells (17). CD44 expression was shown to correlate with in vitro plating efficiency in laryngeal cancer cell lines and in patients with early laryngeal cancer with local tumor control after radiotherapy (18). Of interest, in this dataset, no correlation was observed between the in vitro intrinsic radiosensitivity of the cell lines and CD44 expression, suggesting a possibly higher impact of the number of CSCs or clonogens compared with their intrinsic radioresistance for local tumor control.…”
Section: Radioresistance Of Tumors Is Mediated By Cscssupporting
confidence: 87%
“…This approach provides a rational basis for the development of biomarkers that are predictive for local tumor control after radiotherapy and for CSCtargeting strategies that in combination with radiotherapy may lead to considerable advances in tumor curability in the clinical setting. Recently, for the first time, the applicability of a CSCrelated surface marker as a biomarker bearing predictive potential for local tumor control after radiotherapy was shown in patients with laryngeal cancer (18,38). Consistent with preclinical experiments showing the importance of the intertumoral heterogeneity of CSC density for local tumor control after radiotherapy, a comparison of different gene signatures revealed a significant correlation with local tumor control only for the CD44 mRNA and CD44 immunohistochemical score.…”
Section: Clinical-translational Advancesmentioning
confidence: 57%
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“…CD44 is a widely explored CSC marker in HNSCC (30,36,37). A study by de Jong and colleagues showed that CD44 and CD44 protein levels significantly predict local recurrence after radiotherapy in patients with early-stage laryngeal cancers (38). Here, we showed that patients with surgically resected tumors with no detectable CD44 protein expression have increased locoregional tumor control rates compared with those with CD44 protein-expressing tumors.…”
Section: Discussionmentioning
confidence: 53%
“…In this issue of Clinical Cancer Research, de Jong and colleagues (1) report that CD44 expression correlates with local tumor control of early laryngeal cancer treated by radiotherapy alone.…”
mentioning
confidence: 99%