CD44 variant 6 (CD44v6) expression as a progression marker in benign, premalignant and malignant oral epithelial tissues

Bahar, Rumana; Kunishi, Masanori; Kayada, Yoshiaki; Yoshiga, Koji

doi:10.1016/s0901-5027(97)80010-0

Cited by 27 publications

(23 citation statements)

References 20 publications

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“…In addition, in most cases, staining was limited to the basal and lower levels of the ductal papillomas similar to normal control oral epithelium but in the majority of papillary SCCA, staining of CD44 extended throughout the entire thickness of the lesion. The level of staining intensity of the papillary SCCA in this study was more compatible with that reported by Bahar et al for oral squamous papillomas than that reported for most types of invasive carcinoma in the sinonasal and breast locations previously studied as well [1][2][3][4][5]. No prior studies evaluating the expression of CD44 in papillary SCCA as compared to other variants of oral SCCA could be found in a search of the literature.…”

Section: Discussionsupporting

confidence: 91%

“…It has been shown to be universally present in sinonasal ductal papillomas but lose expression when invasive squamous cell carcinoma (SCCA) arises in these lesions [1]. Similar results have been shown comparing intraductal breast papillomas to invasive papillary carcinoma [2][3][4].It has also been demonstrated to be downregulated in oral dysplasia and SCCA when compared to normal oral epithelium, epithelial hyperplasia, and oral squamous papillomas [5]. Oral squamous papillomas in particular have been shown to stain strongly to CD44, often more strongly than the normal oral epithelium [5].…”

Section: Introductionmentioning

confidence: 53%

“…While epithelial hyperplasia stained compatible to normal epithelium and squamous papillomas stained comparable or stronger to oral epithelium, 80 % of dysplastic lesions and 100 % of SCCA showed loss of expression to CD44v6 [5]. They concluded that CD44v6 might be useful as a progression marker of oral dysplastic and invasive lesions [5]. An earlier study by Herold-Mende et al evaluated multiple splice variants of CD44 in normal oral epithelium, dysplasia, and oral squamous cell carcinoma and found downregulation of certain variants (CD44v7,v8, and v10) with the maintenance of others (CD44v5 and v6) in the cases of squamous cell carcinoma [31].…”

Section: Discussionmentioning

confidence: 96%

“…CD44 staining on the papillary SCCA group revealed 100 % of cases exhibiting moderate or strong staining epithelium as a benchmark for staining level. While epithelial hyperplasia stained compatible to normal epithelium and squamous papillomas stained comparable or stronger to oral epithelium, 80 % of dysplastic lesions and 100 % of SCCA showed loss of expression to CD44v6 [5]. They concluded that CD44v6 might be useful as a progression marker of oral dysplastic and invasive lesions [5].…”

Section: Discussionmentioning

confidence: 99%

“…Bahar et al [5] evaluated a different variant of CD44, CD44v6, with intraoral lesions. They studied 10 cases of oral epithelial hyperplasia, 8 cases of oral squamous papilloma, 19 cases of oral epithelium with dysplasia, and 38 cases of oral SCCA using the staining of normal oral Fig.…”

Section: Discussionmentioning

confidence: 99%

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CD44 Expression in Intraoral Salivary Ductal Papillomas and Oral Papillary Squamous Cell Carcinoma

Fitzpatrick

Montague

Cohen

et al. 2012

Head and Neck Pathol

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CD44 is a transmembrane adhesion molecule which has been previously shown to be useful in the differentiation of benign papillary lesions from invasive carcinoma in several different areas including sinonasal mucosa and breast tissue. CD44 expression has previously been shown to be lost in invasive carcinoma and retained in benign papillary lesions in both of the above locations. In addition, studies have evaluated oral mucosal lesions for CD44 expression and found a loss with invasive squamous cell carcinoma when compared to normal epithelium, hyperplasia, and squamous papillomas, which stained particularly strongly. To the best of our knowledge, no study has evaluated CD44 expression when comparing salivary ductal papillomas in comparison to oral papillary SCCA. In this study 18 cases of intraductal papilloma were compared to 19 cases of oral papillary SCCA. Within the ductal papilloma group, all cases stained either absent (6 %), weakly (33 %), or moderately (61 %) with 76 % expressing the stain diffusely and 24 % focally. In comparison, the papillary squamous cell carcinoma cases expressed the CD44 moderately (26 %) or strongly (74 %) with 100 % showing diffuse staining. Thus, the CD44 expression was contrary to expectation based on previous studies, which we hypothesize is due to the extremely well differentiated nature of papillary SCCA which expressed CD44 staining compatible with levels previously reported with oral squamous papillomas than invasive carcinoma.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

CD44 Expression in Intraoral Salivary Ductal Papillomas and Oral Papillary Squamous Cell Carcinoma

Fitzpatrick

Montague

Cohen

et al. 2012

Head and Neck Pathol

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Gains and losses of adhesion molecules (CD44, E‐cadherin, and β‐catenin) during oral carcinogenesis and tumour progression

Bànkfalvi

Krassort

Buchwalow

et al. 2002

The Journal of Pathology

129

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The aim of this study was to define whether or not the impaired expression of CD44, E-cadherin (E-cad), and beta-catenin (beta-cat) correlates with the clinical evolution and prognosis of oral cancer. Ninety-three primary oral squamous cell carcinomas (OSCCs) with tumour-adjacent normal and/or dysplastic mucosa, 30 associated metastases, and 12 recurrences were immunostained for CD44s, -v3, -v4, -v5, -v6, -v7, -v9, E-cad, and beta-cat. In non-neoplastic epithelium, all molecules investigated were constitutively expressed in the basal layers. In the majority of dysplasias, immunoreactivity for all adhesion molecules was increased, but there was restricted loss for CD44s, E-cad, and beta-cat in a few cases. In carcinomas, a striking accumulation of CD44s, v3, v4, v9 and a loss of E-cad/beta-cat were observed at the invasive tumour front. In metastases and recurrences, besides a loss of CD44s, v4, v7, and E-cad, a significant increase of v9 was recorded, whereas CD44v5 and v6 remained unchanged. Clinically, reduced expression of CD44v3, E-cad, and changes of CD44v9 phenotype within the primary tumours correlated significantly with poor prognosis; decreased beta-cat expression was a predictive marker for nodal metastases. These findings indicate that there is some perturbed expression of adhesion molecules during the stepwise course of oral carcinogenesis and tumour progression. Distinct phenotypic alterations project poor prognosis, while others predict metastasis. Some of these restricted molecular changes may serve as potential targets for future antibody-based tumour therapy.

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Expression of CD44 in Uterine Cervical Squamous Neoplasia: A Predictor of Microinvasion?

Callagy

O’Grady

Butler

et al. 2000

Gynecologic Oncology

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CD44 variant 6 (CD44v6) expression as a progression marker in benign, premalignant and malignant oral epithelial tissues

Cited by 27 publications

References 20 publications

CD44 Expression in Intraoral Salivary Ductal Papillomas and Oral Papillary Squamous Cell Carcinoma

CD44 Expression in Intraoral Salivary Ductal Papillomas and Oral Papillary Squamous Cell Carcinoma

Gains and losses of adhesion molecules (CD44, E‐cadherin, and β‐catenin) during oral carcinogenesis and tumour progression

Expression of CD44 in Uterine Cervical Squamous Neoplasia: A Predictor of Microinvasion?

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