CD64 on monocytes and granulocytes in severe acute bronchiolitis: Pilot study on its usefulness as a bacterial infection biomarker

García-Salido, Alberto; Serrano-González, Ana; Casado‐Flores, Juan; Sierra-Colomina, Montserrat; Azagra-Garde, Amelia Martínez de; Teresa, María; Melén, Gustavo J.; Ramírez-Orellana, Manuel

doi:10.1002/jlb.4ab0417-152rrr

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…2 d). CD64 is an FCγ receptor of immunoglobulin G and increases surface expression on monocytes and granulocytes in conditions of infection and systemic inflammation [17] . In cirrhosis, both CD169 + and CD169 − monocytes had increased surface expression of CD64 in comparison with healthy controls, while CD169 + monocytes had higher expression than CD169 − monocytes (Fig.…”

Section: Resultsmentioning

confidence: 99%

Elevated CD169 expressing monocyte/macrophage promotes systemic inflammation and disease progression in cirrhosis

Xu,

Huang,

Zheng

et al. 2024

Clin Exp Med

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Systemic inflammation is related to disease progression and prognosis in patients with advanced cirrhosis. However, the mechanisms underlying the initiation of inflammation are still not fully understood. The role of CD169+ monocyte/macrophage in cirrhotic systemic inflammation was undetected. Flow cytometry analysis was used to detect the percentage and phenotypes of CD169+ monocytes as well as their proinflammatory function in patient-derived cirrhotic tissue and blood. Transcriptome differences between CD169+ and CD169− monocytes were also compared. Additionally, a mouse model with specific depletion of CD169+ monocytes/macrophages was utilized to define their role in liver injury and fibrosis. We observed increased CD169 expression in monocytes from cirrhotic patients, which was correlated with inflammatory cytokine production and disease progression. CD169+ monocytes simultaneously highly expressed M1- and M2-like markers and presented immune-activated profiles. We also proved that CD169+ monocytes robustly prevented neutrophil apoptosis. Depletion of CD169+ monocytes/macrophages significantly inhibited inflammation and liver necrosis in acute liver injury, but the spontaneous fibrin resolution after repeated liver injury was impaired. Our results indicate that CD169 defines a subset of inflammation-associated monocyte that correlates with disease development in patients with cirrhosis. This provides a possible therapeutic target for alleviating inflammation and improving survival in cirrhosis.

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Section: Resultsmentioning

confidence: 99%

Elevated CD169 expressing monocyte/macrophage promotes systemic inflammation and disease progression in cirrhosis

Xu,

Huang,

Zheng

et al. 2024

Clin Exp Med

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“…Más recientemente se han venido estudiando nuevos biomarcadores para diferenciar infecciones virales y bacterianas (2) (23) (24) (25) (26) (27), pero muchas instituciones, al igual que la nuestra, carecen de los recursos para realizarlos. Otras técnicas de aislamiento microbiológico e imágenes como la fibrobroncoscopia, el lavado bronquioalveolar, el cepillado bronquial, la tomografía de tórax y la resonancia magnética del tórax solo están indicadas en circunstancias especiales (11).…”

Section: Introductionunclassified

Factores relacionados con la estancia hospitalaria y el uso de antibióticos en menores de 5 años hospitalizados por infección respiratoria aguda baja, en un hospital de tercer nivel

López Pérez,

Galán Gutiérrez,

Lancheros Delgadillo

2023

Rev. Med.

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La enfermedad respiratoria aguda baja causa importante morbimortalidad en menores de 5 años. Conocer los factores que inciden en la estancia hospitalaria y el uso de antibióticos ayudará al mejor entendimiento de esta entidad. Población y métodos: trabajo retrospectivo transversal realizado entre enero de 2010 y junio de 2011 en un hospital de tercer nivel localizado en Bogotá (Colombia), a una altura de 2600 m s. n. m., que involucra a menores de 5 años hospitalizados con enfermedad respiratoria baja. Se revisan antecedentes, características clínicas, de laboratorio y radiológicas y se correlacionan con la estancia hospitalaria y el uso de antibióticos. Se analiza su significancia (p < 0,05). Resultados: se obtuvieron 1063 casos de los cuales se excluyeron 89 para un total de 974. El uso de antibióticos, hipoxemia al ingreso, presencia de retracciones, el virus sincitial respiratorio y, asociadas al uso de antibióticos, las cardiopatías congénitas, la presencia de consolidación y las altas temperaturas en las primeras 72 horas, prolongaron la estancia hospitalaria de manera independiente. El uso de antibióticos se asoció con el número de días de enfermedad antes de la consulta, reconsulta, fiebre al ingreso o su persistencia en el hospital, las retracciones, el mayor recuento absoluto de leucocitos o neutrófilos, el virus sincitial respiratorio, el mayor valor de la proteína C reactiva, duración del oxígeno suplementario, la presencia radiológica de consolidación o derrame pleural. Conclusiones: en la estancia hospitalaria de nuestros pacientes no influyeron variables de gravedad descritas para la enfermedad respiratoria. Hubo factores clínicos, de laboratorio y radiológicos asociados al uso de antibióticos.

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“…However, in bacteria-infected individuals, the expression of CD64 on neutrophils can be markedly elevated (> 10-fold) within a few hours, which allows differentiation between resting and activated neutrophils [ 11 ]. Many studies have demonstrated that the expression of CD64 on neutrophils measured as an index had higher sensitivity and specificity for infection: The neutrophil CD64 (nCD64) index significantly increases in bacteria-infected diseases, such as sepsis, systemic infection, bronchitis, and bacterial peritonitis [ 6 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil CD64 index as a superior indicator for diagnosing, monitoring bacterial infection, and evaluating antibiotic therapy: a case control study

et al. 2022

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Background Neutrophil CD64 (nCD64) index has been widely studied as an indication of bacteria-infected diseases, but the exact usage of nCD64 index in monitoring infections remains debated. So this study aims to investigate the functionality of nCD64 index in tracking infections’ progression and evaluating antibiotic therapy. Methods 160 participants (36 healthy controls, 34 culture-negative patients, 56 respiratory tract infected patients, and 34 bloodstream infected patients) were recruited and divided into groups. Data on nCD64 index, T lymphocyte subsets, and conventional indicators, including white blood cell count, neutrophil to lymphocyte ratio, procalcitonin, and C-reactive protein, were tested and compared. Results Bacteria-infected patients had significantly higher nCD64 indexes (p < 0.05), especially patients with both bloodstream and respiratory tract infections. The nCD64 index could identify infected patients from culture-negative patients or controls, which conventional indicators cannot achieve. We followed up with 24 infected patients and found that their nCD64 indexes were promptly down-regulated after effective antibiotic therapy (3.16 ± 3.01 vs. 1.20 ± 1.47, p < 0.001). Conclusion The nCD64 index is a sensitive indicator for clinical diagnosis of bacterial infection, especially in monitoring infection and evaluating antibiotics’ efficacy. Therefore, nCD64 has the potential to improve diagnostic accuracy and provide rapid feedback on monitoring disease progression in infected patients.

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CD64 on monocytes and granulocytes in severe acute bronchiolitis: Pilot study on its usefulness as a bacterial infection biomarker

Cited by 10 publications

References 21 publications

Elevated CD169 expressing monocyte/macrophage promotes systemic inflammation and disease progression in cirrhosis

Elevated CD169 expressing monocyte/macrophage promotes systemic inflammation and disease progression in cirrhosis

Factores relacionados con la estancia hospitalaria y el uso de antibióticos en menores de 5 años hospitalizados por infección respiratoria aguda baja, en un hospital de tercer nivel

Neutrophil CD64 index as a superior indicator for diagnosing, monitoring bacterial infection, and evaluating antibiotic therapy: a case control study

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