CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues.

Prall, Friedrich; Nollau, Peter; Neumaier, Michael; Haubeck, H.-D.; Drzeniek, Zofia; Helmchen, Udo; Löning, Thomas; Wagener, Christoph

doi:10.1177/44.1.8543780

Cited by 182 publications

(139 citation statements)

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“…In contrast to the putative tumor suppressive functions, CEACAM1 is not expressed in several normal epithelial tissues (Prall et al, 1996), including thyroid as shown by our current studies. It has also been found to be upregulated in primary lung carcinomas when compared with adjacent normal lung tissue (Ohwada et al, 1994;Wang et al, 2000).…”

Section: Discussioncontrasting

confidence: 66%

“…CEACAM1 is an example of a transmembrane protein widely expressed by epithelial and endothelial cells, and most types of hematopoietic cells tissues (Prall et al, 1996;Obrink, 1997;Singer et al, 2000;Plunkett and Ellis, 2002). CEACAM1 shows both homophilic adhesion Ocklind, 1984 1446/id as well as heterophilic binding to other CEA family members in vitro (Oikawa et al, 1992) and is believed to be an important player in maintenance of normal tissue architecture.…”

Section: Introductionmentioning

confidence: 99%

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CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases

Winer

et al. 2006

Oncogene

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Section: Discussioncontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases

Winer

et al. 2006

Oncogene

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“…However, when considered more closely, it is noteworthy that all the isolates from men bound CEACAM5 whereas only two-thirds of the isolates from women did so. Interestingly, in this regard, squamous cells of the lower genital tract tend to express CEACAM5 whereas columnar epithelial cells of the female endocervical and upper genital tract instead express CEACAM1 (27). While CEACAM family expression within the male urethra has not been mapped, the difference in receptor specificities of the recovered isolates makes it enticing to consider whether there is selection for CEACAM5 binding at this site.…”

Section: Discussionmentioning

confidence: 99%

“…Epithelial CEACAMs (CEACAM1, CEACAM5, and CEACAM6) are all presumed to facilitate bacterial colonization (25,26). In the female genital tract, squamous epithelia express CEACAM5, whereas CEACAM1 is expressed on columnar epithelia of the endocervix and uterus (27), allowing each to be accessible for direct docking by the gonococci. Moreover, CEACAM1 is widely expressed on lymphocytes, and CEACAM1-induced signaling can influence immune cell activation (28)(29)(30)(31)(32)(33)(34)(35), potentially providing a mechanism for immune evasion by N. gonorrhoeae.…”

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confidence: 99%

Selection for a CEACAM Receptor-Specific Binding Phenotype during Neisseria gonorrhoeae Infection of the Human Genital Tract

et al. 2015

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Infections by Neisseria gonorrhoeae are increasingly common, are often caused by antibiotic-resistant strains, and can result in serious and lasting sequelae, prompting the reemergence of gonococcal disease as a leading global health concern. N. gonorrhoeae is a human-restricted pathogen that primarily colonizes urogenital mucosal surfaces. Disease progression varies greatly between the sexes: men usually present with symptomatic infection characterized by a painful purulent urethral discharge, while in women, the infection is often asymptomatic, with the most severe pathology occurring when the bacteria ascend from the lower genital tract into the uterus and fallopian tubes. Classical clinical studies demonstrated that clinically infectious strains uniformly express Opa adhesins; however, their specificities were unknown at the time. While in vitro studies have since identified CEACAM proteins as the primary target of Opa proteins, the gonococcal specificity for this human family of receptors has not been addressed in the context of natural infection. In this study, we characterize a collection of low-passage-number clinicalspecimen-derived N. gonorrhoeae isolates for Opa expression and assess their CEACAM-binding profiles. We report marked in vivo selection for expression of phase-variable Opa proteins that bind CEACAM1 and CEACAM5 but selection against expression of Opa variants that bind to the neutrophil-restricted decoy receptor CEACAM3. This is the first study showing phenotypic selection for distinct CEACAM-binding phenotypes in vivo, and it supports the opposing functions of CEACAMs that facilitate infection versus driving inflammation within the genital tract.

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“…12 The present study was designed to investigate the expression pattern of CEACAM1 in the human placental components and thus its potential implication in implantation and placentation. To investigate the expression of CEACAM1, immunohistochemistry on paraffin-embedded specimens and flow cytometry on isolated trophoblast was performed using the mAb 4D1/C2, 13,14 which had been previously used to study expression in several normal human tissues, 15 as well as expression in normal and malignant mammary gland and in endometrial neoplasia. 16,17 …”

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The Adhesion Molecule CEACAM1 (CD66a, C-CAM, BGP) Is Specifically Expressed by the Extravillous Intermediate Trophoblast

Bamberger

Sudahl

Löning

et al. 2000

The American Journal of Pathology

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CEACAM1 (CD66a, C-CAM, BGP) is an adhesion molecule of the carcinoembryonic antigen family which has been shown to be normally expressed at the apical pole of epithelial cells, including the apical pole of endometrial surface and glandular epithelia. The purpose of the present study was to investigate its expression pattern at the maternal-fetal interface, and thus to determine whether CEACAM1 could be implicated in the human implantation process. For this purpose, we performed immunohistochemistry using the 4D1/C2 monoclonal antibody (mAb) as well as flow cytometry and Western blot on isolated trophoblast populations. On the maternal side of the maternalfetal interface, CEACAM1 was present in epithelial cells of pregnancy endometrium as well as in small endometrial vessels, whereas it was absent from decidual cells. On the fetal side, CEACAM1 was strongly expressed by the extravillous (intermediate) trophoblast at the implantation site, as well as by extravillous trophoblast cells with invasive phenotype in primary culture, as shown by flow cytometry and Western blot. Expression was also observed in placental villous core vessels but was absent from both villous cyto-and syncytiotrophoblasts throughout the pregnancy. We conclude that, given its specific ex- The trophoblast is the first tissue to differentiate in the mammalian conceptus and its normal development and specific properties are crucial for both implantation and further survival of the embryo. Furthermore, the placenta is unique in its ability to proliferate and invade another tissue in a controlled fashion and is thus a very interesting model for the study of molecular mechanisms involved in these processes, and for differentiating them from those implicated in tumor progression.During development of the human placenta, the stem cell-like cytotrophoblast proliferates and gives rise to the differentiated syncytiotrophoblast on the villous surface and to the invasive intermediate trophoblast, which invades the maternal tissues and provides the anchoring of the placenta and the conceptus at the maternal-fetal interface. 1 The extravillous trophoblast can be further divided into proximal extravillous trophoblast originating from the anchoring villi; deep interstitial extravillous trophoblast invading the decidual stroma and the myometrium; and endovascular trophoblast, which assumes endothelial-like characteristics. [2][3][4] Starting with the initial contact which is made between the trophoblast and the apical plasma membrane of the endometrial surface epithelial cells, through the invasion of the decidua and the invasion of decidual vessels with gradual colonization of the arterial wall of the spiral arteries, cellular contacts mediated by cell adhesion molecules are of essential importance.Cell adhesion molecules are important mediators of tissue architecture and cellular polarity which also mod-

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CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues.

Cited by 182 publications

References 3 publications

CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases

CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases

Selection for a CEACAM Receptor-Specific Binding Phenotype during Neisseria gonorrhoeae Infection of the Human Genital Tract

The Adhesion Molecule CEACAM1 (CD66a, C-CAM, BGP) Is Specifically Expressed by the Extravillous Intermediate Trophoblast

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