CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?

Abstract

CD69 has been identified as an early activation marker of lymphocytes. However, recent work has indicated that CD69 plays an essential role for the regulation of inflammatory processes. Particularly, CD69 is highly expressed by lymphocytes at mucosal sites being constantly exposed to the intestinal microflora (one of the nature's most complex and most densely populated microbial habitats) and food antigens, while only a small number of circulating leukocytes express this molecule. In this review we will discuss the role of CD69 in mucosal tissue and consider CD69 as a potential target for the development of novel treatments of intestinal inflammation.

Inflammation-induced CD69+ Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1

“…Engagement of CD69 can activate NK and T cells, resulting in the upregulated cytotoxic activity and pro-inflammatory cytokines secretion (Sancho et al, 2005).Owing to the absence of a known ligand, the biological function and underlying mechanisms of CD69 have not been extensively studied. In recent years, CD69 has been reported as the negative regulating factor for the T cell response because CD69-deficient mice develop more severe T cell-mediated autoimmune diseases, meanwhile, CD69 deficiency could promote the antitumor response (Radulovic and Niess, 2015;Wieland and Shipkova, 2016). Furthermore, CD69 engagement can not only induce apoptosis in monocytes and eosinophils, and also suppress IL-1 receptor-or CD3-mediated T cell proliferation (Ramírez et al, 1996;Walsh et al, 1996;Cosulich et al, 1987).…”

Applying SWATH Mass Spectrometry to Investigate Human Cervicovaginal Fluid During the Menstrual Cycle1

“…This protein is an leukocytic early activation marker [47]. Interestingly this protein like L-Plastin has been found in circulating leukocytes and is presence in intestinal mucosa where by it functions in an inflammatory role.…”

“…Interestingly this protein like L-Plastin has been found in circulating leukocytes and is presence in intestinal mucosa where by it functions in an inflammatory role. It has been suggested to play a role in preventing bacterial pathogens from crossing the external layers of mucosa into the deeper inner tissues [47]. CD69 is expressed in memory T cells and regulatory T cells, in intestinal tissue.…”

Role of peripheral dopaminergic system in the pathogenesis of experimental colitis in rats

“…Functional studies performed in in vitro conditions, reported inhibitory effects of dopamine on fMLPstimulated superoxide anion production by human neutrophils [34]. Dopamine has also been reported to attenuate CD11b/CD18 expression in neutrophils, with consequently diminished ability of human neutrophil adherence to the endothelium, as well as a decrease in the production of ROS and superoxide anions, cell migration and phagocytic activity [35].…”