2020
DOI: 10.1101/2020.10.08.328930
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CD73 maintains hepatocyte metabolic integrity and mouse liver homeostasis in a sex-dependent manner

Abstract: Background & AimsMetabolic imbalance and inflammation are common features of chronic liver diseases. Molecular factors controlling these mechanisms represent potential therapeutic targets. One promising target is CD73, the major enzyme that dephosphorylates extracellular adenosine monophosphate (AMP) to form the anti-inflammatory adenosine. In normal liver, CD73 is expressed on pericentral hepatocytes, which are important for long-term liver homeostasis. The aim of this study was to determine if CD73 has n… Show more

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