Cd8 and Cd45ro T Lymphocytes in Bone Marrow of Gastric Cancer Patients: Correlation With Disseminated Tumor Cells and Disease Outcome

Osinsky, Sergej; Kovelskaya, Antonina; Bubnovskaya, Larissa; Osinsky, Dmitry; Merentsev, Sergej

doi:10.31768/2312-8852.2015.37(1):48-52

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…At the same time the association between pre sence of CD8 and CD45RO T lymphocytes and survival was shown: high density of CD8 + and CD45RO + T cells in primary tumor or high density of CD8 + and CD45RO + T cells in bone marrow are the most favorable for patients. These data may allow to consider intratumoral CD8 and CD45RO T lymphocytes as a "keeping factor" that prevents the exit of tumor cells from primary node, dissemination in the circulation and hit into the distant organs, in particular bone marrow, and allow to assume that tumor cells in bone marrow may be existed in a dormant state through the control by T cells in particular by CD8-positive T cells [63,64].…”

Section: Minimal Residual Diseasementioning

confidence: 99%

Tumor microenvironment and metabolic factors: contribution to gastric cancer

Bubnovskaya

Osinsky

2023

Exp. oncol.

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Summary. Malignancy may be characterized as a state formed in the setting of specific tumor-host relationships at the molecular and cellular microenvironment levels. R.E. Kavetsky and his collaborators distinctly outlined the concept of tumor-host interaction. Tumor is a complicated biological system closely connected with the organism, where it arises and develops. Tumor cells are in the environment of different factors that form tumor microenvironment playing an active role in the disease progression. There are two types of tumor microenvironment: the metabolic microenvironment mediated by factors of tumor microphysiology (blood flow, vascular permeability, oxygenation, extracellular рН, interstitial fluid pressure, etc.) and the cellular-molecular microenvironment comprising interactions between tumor cells and non-tumor cells and the factors of the stromal compartment. Factors of tumor microphysiology can modify the interaction between tumor cells and surrounding non-tumor cells and molecular components and they form the tumor profile that influences the pressure of tumor on the host. The review presents the data concerning the role of metabolic microenvironment of tumor cells from the point of tumor-host interaction in order to employ these parameters to working out the methods of diagnosis and prognosis of disease outcome in patients with gastric cancer. Special attention has been paid to hypoxia as a key factor of metabolic microenvironment that positively affects tumor progression, stimulating its aggressiveness, metastasis and resistance to therapy and is regarded as a factor of unfavorable prognosis. It was shown that there is possible clinical relevance of tumor classification based on the level of tumor oxygenation that may be advantageous for selection of patients for individualized therapy that may give the hope for enhancement of treatment efficacy.

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Section: Minimal Residual Diseasementioning

confidence: 99%

Tumor microenvironment and metabolic factors: contribution to gastric cancer

Bubnovskaya

Osinsky

2023

Exp. oncol.

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“…It was shown that CD45RO + -T cells infiltrating into gastric cancer tissues are functional and have significant prognostic value in human gastric cancer [15]. Moreover the presence of CD8-and CD45RO-positive T cells in bone marrow (BM) of gastric cancer patients demonstrated better overall survival than those with the absence of CD8-and CD45RO-positive T cells in BM [16]. At the same time as it was noted by Mei et al [17], the prognostic value of TILs in gastric cancer remains controversial because of the limited number of studies.…”

Section: Introductionmentioning

confidence: 99%

Tumor-Infiltrating Lymphocytes in Primary Tumor and Bone Marrow in Patients with Gastric Cancer and Overweight

Bubnovskaya¹,

Mikhailenko²,

Merentsev³

et al. 2019

JPP

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Immune infiltration in human tumors is a key prognostic factor. In this aspect it has to be noted that the publications concerning the tumor-infiltrating lymphocytes (TILs) under overweight and obesity are limited, especially in the clinical setting in particular concerning gastric cancer. This study has shown that density of TILs consistently associated with body mass index (BMI) and density of cancer-associated adipocytes (CAA) in tumors, decreased significantly in patients with BMI > 30 having high density of CAA. Hypoxia in tumor does not affect this process. Patients with BMI > 30 having high density of CAA with slight infiltrating of TILs in tumors demonstrated better overall survival than the same patients with BMI < 25 whereas the same patients with BMI < 25 but with low density of CAA have shown much longer overall survival. Presence of TILs in BM was not affected by both the high density of CAA and level of hypoxia in primary tumor; moreover it has not been associated with BMI as well as patients survival time. Understanding the metabolic changes that occur in obese individuals may help to pave the way for more effective treatments for patients with gastric cancer having overweight.

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Clinicopathological significance and prognostic role of LAG3 + tumor-infiltrating lymphocytes in colorectal cancer; relationship with sidedness

et al. 2023

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Background It is well-documented that the interplay between tumor-infiltrating lymphocytes (TILs) and tumor cells is a major determining factor in cancer progression. CD45RO seems to be a reliable indicator for predicting prognosis and disease outcome, along with CD3 and CD8 markers. LAG-3 is another important marker that overexpresses on TILs in a variety of cancers and is associated with disease prognosis; however, its prognostic impact is controversial. Hence, in the present study, we aimed to investigate the presence of CD45RO + , LAG3 + , CD3 + , and CD8 + lymphocytes in CRC tumor tissues and their association with clinicopathological parameters of the disease as well as patients' survival, according to primary tumor locations. Methods Expression of CD45RO, LAG3, CD3, and CD8 was immunohistochemically assessed in tissue sections of 136 patients with CRC. The percentages of TILs expressing these markers were then separately determined in both invasive margin (IM) and center of tumor (CT). Their associations with clinicopathological factors and patients’ survival were analyzed in the entire cohort and the subgroups of patients with right- and left- rectum tumors. Results Based on our observation, CD45RO + and CD3 + cells were the most frequent infiltrated lymphocytes in both CT and IM regions of colon tumor tissue. Whilst, LAG3 + lymphocytes were the least frequent subset in both areas. Statistical analysis indicated that the frequency of CD45RO + TILs was positively associated with advanced TNM stages (III/IV), in the entire cohort and right-sided tumors (P < 0.05). LAG3 + TILs in IM were also increased in tumor tissues with higher T-stages in the entire cohort (P = 0.027). In univariate analysis, high score of CD45RO + TILs in IM was associated with better overall survival in the entire cohort. High score of CD8 + and CD45RO + lymphocytes in IM were also associated with improved survival in patients with right-sided tumors. Conclusions Our findings generally suggest that the clinicopathological and prognostic significance of immune system-related markers such as CD45RO and LAG3 depends on the primary tumor sides. Our results collectively demonstrated that infiltration of CD45RO + lymphocytes in IM could be an independent prognostic factor in a site-dependent manner.

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Cd8 and Cd45ro T Lymphocytes in Bone Marrow of Gastric Cancer Patients: Correlation With Disseminated Tumor Cells and Disease Outcome

Cited by 5 publications

References 16 publications

Tumor microenvironment and metabolic factors: contribution to gastric cancer

Tumor microenvironment and metabolic factors: contribution to gastric cancer

Tumor-Infiltrating Lymphocytes in Primary Tumor and Bone Marrow in Patients with Gastric Cancer and Overweight

Clinicopathological significance and prognostic role of LAG3 + tumor-infiltrating lymphocytes in colorectal cancer; relationship with sidedness

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