CD8/CD38 activation yields important clinical information of effective antiretroviral therapy: Findings from the first year of the CIPRA-SA cohort

Glencross, Deborah K.; Jánossy, G.; Coetzee, Lindi M.; Lawrie, Denise; Scott, Lesley; Sanne, Ian; McIntyre, James; Stevens, Wendy

doi:10.1002/cyto.b.20391

Cited by 40 publications

(79 citation statements)

References 38 publications

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“…This study also confirmed that laser stability was optimized at a lower sample flow rate (59) and is recommended where such shifts of antigen binding/mean fluorescence intensity or MFI are used to interpret clinical follow-up (e.g. CD38MFI to predict response of HIV/AIDS patients to antiretroviral therapy) (64,65).…”

Section: Continuous Quality Control (Cqc) Of Flow Cytometerssupporting

confidence: 69%

A model for continuous quality control incorporating sample‐to‐sample assessment of optical alignment, fluorescence sensitivity, and volumetric operation of flow cytometers

Lawrie

Coetzee

Glencross

2010

Cytometry Part B Clinical

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Section: Continuous Quality Control (Cqc) Of Flow Cytometerssupporting

confidence: 69%

A model for continuous quality control incorporating sample‐to‐sample assessment of optical alignment, fluorescence sensitivity, and volumetric operation of flow cytometers

Lawrie

Coetzee

Glencross

2010

Cytometry Part B Clinical

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“…The treatment efficacy of HAART is mainly evaluated by the decrease in HIV-1 viral load and the degree of reconstitution of the immune system. 5 However, the implications of the rebuilding of immune function for the development of IRIS in AIDS patients have not been widely reported. In particular, the immunopathogenesis of IRIS is rarely elucidated.…”

mentioning

confidence: 99%

The Immune Pathogenesis of Immune Reconstitution Inflammatory Syndrome Associated with Highly Active Antiretroviral Therapy in AIDS

Zheng

Zhou

et al. 2014

AIDS Research and Human Retroviruses

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The present study investigated the immunological pathogenesis of immune reconstitution inflammatory syndrome (IRIS) in acquired immunodeficiency syndrome (AIDS) patients undergoing highly active antiretroviral therapy (HAART). A total of 238 patients with AIDS who received initial HAART were included in this prospective cohort study. Blood samples were collected immediately, at baseline, at week 12, and at week 24 after initial HAART and at the onset of IRIS. Lymphocyte subsets, Th1 and Th2 cytokines, and interleukin (IL)-7 levels were measured by flow cytometry or ELISA. Among the 238 patients with AIDS who received HAART, 47 patients developed IRIS. The percentages of CD4 + and CD8 + naive, memory, and activated cells exhibited no significant differences between AIDS patients with and without IRIS 24 weeks after initial HAART. The percentage of CD4 + CD25 + Foxp3 + regulatory T cells was lower in IRIS patients than in non-IRIS patients before HAART, 12 weeks after HAART, 24 weeks after HAART, and at the onset of IRIS. IL-2 and interferon (IFN)-c levels were significantly higher at week 4 and at the onset of IRIS in IRIS patients than in non-IRIS patients. In contrast, IL-4 and IL-10 levels were significantly lower at week 4 and at the onset of IRIS in IRIS patients than in non-IRIS patients. Plasma IL-7 decreased gradually with the progression of HAART. The level of IL-7 was higher in IRIS patients than in non-IRIS patients at all follow-up time points. An imbalance of Th1/Th2 cytokines, a consistently low CD + CD25 + Fox3 + percentage, and a high IL-7 level may be crucial in the pathogenesis of IRIS in AIDS patients who had received HAART.

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“…HIV RNA measurements were performed using Abbott Realtime HIV-1 assay and CD4 measurements by the PanLeucogated method. [11,12] …”

Section: Study Outcomesmentioning

confidence: 99%

Short-term treatment outcomes of children starting antiretroviral therapy in the intensive care unit, general medical wards and outpatient HIV clinics at Red Cross War Memorial Children’s Hospital, Cape Town, South Africa: A retrospective cohort study

et al. 2015

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CD8/CD38 activation yields important clinical information of effective antiretroviral therapy: Findings from the first year of the CIPRA-SA cohort

Cited by 40 publications

References 38 publications

A model for continuous quality control incorporating sample‐to‐sample assessment of optical alignment, fluorescence sensitivity, and volumetric operation of flow cytometers

A model for continuous quality control incorporating sample‐to‐sample assessment of optical alignment, fluorescence sensitivity, and volumetric operation of flow cytometers

The Immune Pathogenesis of Immune Reconstitution Inflammatory Syndrome Associated with Highly Active Antiretroviral Therapy in AIDS

Short-term treatment outcomes of children starting antiretroviral therapy in the intensive care unit, general medical wards and outpatient HIV clinics at Red Cross War Memorial Children’s Hospital, Cape Town, South Africa: A retrospective cohort study

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