CD8+CXCR5+ T cells in tumor-draining lymph nodes are highly activated and predict better prognosis in colorectal cancer

Identification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5 + CD8 + T cell abundance

“…18 In HBV-related liver cancer, CXCR5 + CD8 + T cells are likely to be initially induced by viral responses, and then act on tumor cells. 19 As it is demonstrated in previous studies, CXCR5 + CD8 + T cell frequency is positively correlated with the overall survival of patients with various malignancies, including the malignancies mentioned above along with colorectal, 20 pancreas, 21 lung 22 and thyroid 23 cancer. Intriguingly, a study revealed that CXCR5 + CD8 + T cells provide a proliferation burst after PD-1 blockade in LCMV infection, suggesting its sensitivity to anti-PD-1 therapy.…”

“…Intriguingly, we found CXCR5 + CD8 + T cells could serve as a more powerful prognosticator than CD8 + T cells in MIBC, which was in line with its impressive anti-tumor function as discovered in other tumor types. [18][19][20][21][22][23] We have previously reported several immune cells infiltration associated with ACT benefit in MIBC, such as tumor-infiltrating neutrophils, mast cells, B cells, and IL-22 + cell. 25,[31][32][33][34] Remarkably, we revealed the outstanding predictive ability of CXCR5 + CD8 + T cells in response to ACT in MIBC.…”

<p>Predictive Value of Postoperative Peripheral CD4+ T Cells Percentage in Stage I–III Colorectal Cancer: A Retrospective Multicenter Cohort Study of 1028 Subjects</p>

“…However, one study confirmed that the prevalence of some T cell subsets in the tumor was not associated with their frequency in peripheral blood. 25 Secondly, genomic characteristics including microsatellite instability, KRAS, NRAS, and BRAF, which are proposed as predictors of CRC patient outcomes, 26 were not considered in this study due to the lack of identification method for these characteristics in the hospitals before 2016.…”

Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure

“…This subset shows heterogeneous phenotype and gene expression profile depending on the pathogenic context, still it is distinct from the CXCR5 − counterpart pool and maintain cytotoxic properties ( 144 ). In addition of being part of the TCF-1 + /PD-1 int progenitor pool ( 129 , 145 ), these cells have been described as having variable levels of exhaustion and being similar to Tfh cells ( 20 , 108 , 129 , 131 , 141 , 146 – 149 ). This is reflected in their capacity to help in the control of viral infection and of tumor growth, in the promotion of inflammation and in the induction of B cell responses ( 108 , 136 , 137 , 144 ).…”

“…Finally, CD160 + CD8 T cells have been shown to express higher PD-1 levels than the CD160 − counterpart, to have less proliferative and cytotoxic potential and to be enriched among CD8 TILs in pancreatic cancer patients ( 69 ). Recently, a CXCR5 + CD8 T cell population has been observed to expand in diffuse large B cell lymphoma ( 232 ), follicular lymphoma ( 144 ) and HBV-related hepatocellular carcinoma ( 137 , 139 , 141 , 149 ). Circulating, tumor infiltrating, and lymphoid CXCR5 + CD8 T cells were shown to co-express PD-1 and, in contrast with chronic viral infection ( 129 , 131 , 134 , 148 ), TIM-3 ( 134 , 140 ), however they were functionally less exhausted than the CXCR5 − CD8 T cell population and expressed genes related to stem-like plasticity and cytotoxicity ( 140 , 141 , 149 ).…”