1992
DOI: 10.1111/j.1398-9995.1992.tb02243.x
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CD8+ T cells in allergy

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Cited by 13 publications
(3 citation statements)
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“…They reported a suppressive effect of early activated CD8 + T cells on IgE production that was transferable to naive animals (54). Interestingly, in vivo depletion of CD8 + T cells before sensitization with ricin and allergen did not lead to the predicted enhancement in IgE production, but instead, inhibited the development of IgE responses (55). From these experiments, they concluded that two distinct populations or different functional stages of CD8 + spleen T cells may exist, one which suppresses IgE responses through the production of IFN-~/ and the other which augments IgE responses by an unknown mechanism.…”
Section: Discussionmentioning
confidence: 98%
“…They reported a suppressive effect of early activated CD8 + T cells on IgE production that was transferable to naive animals (54). Interestingly, in vivo depletion of CD8 + T cells before sensitization with ricin and allergen did not lead to the predicted enhancement in IgE production, but instead, inhibited the development of IgE responses (55). From these experiments, they concluded that two distinct populations or different functional stages of CD8 + spleen T cells may exist, one which suppresses IgE responses through the production of IFN-~/ and the other which augments IgE responses by an unknown mechanism.…”
Section: Discussionmentioning
confidence: 98%
“…36 In general, however, CD8 + cells appear to play a down-regulatory role with respect to the induction of IgE 37 and many reports suggest that CD4 + cells are the sole source of type 2 cytokines in cells derived from patients with atopic asthma or rhinitis.…”
mentioning
confidence: 98%
“…CD4+ T cells can be subdivided according to the cyto kines they secrete [1] but there have been very few system atic studies of CD8+ T cell cytokine secretion [2], CD8+ T cells play an essential role in the clearance of virally infect ed cells, induction o f immunity to parasite infection and regulation of IgE production [3,4], CD8+ T cells are report ed to be major interferon (IFN)-y-producing cells and poor producers o f interleukin (IL)-4 [5,6]. The aim of this study was to systematically investigate IL-4 and IFN-y-production from highly purified human CD8+ T cells using a num ber of different stimuli.…”
Section: Introductionmentioning
confidence: 99%