CD8+ T Cell Biology in Cytokine Storm Syndromes

Sekine, Takuya; Galgano, Donatella; Casoni, Giovanna Perinetti; Meeths, Marie; Bryceson, Yenan T.

doi:10.1007/978-3-030-22094-5_9

Cited by 2 publications

(1 citation statement)

References 144 publications

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“…Paraclinical findings suggest a considerable increase in IL-6, ferritin, and C-reactive protein representing an ongoing inflammatory process that can lead to sepsis and consequent multi-organ damages such as kidney failure (11). There is a broad controversy about the exact mechanism of AKI in COVID-19; However, it seems that an underlying occult viral sepsis can develop a cytokine storm and progresses to kidney injury (12).…”

Section: Clinical and Laboratory Findings In Covid-19associated Akimentioning

confidence: 99%

Acute kidney injury due to cytokine storm in patients with COVID-19 infection

2020

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Patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or COVID-19 represents usually a variety range of symptoms related to influenza-like syndrome and respiratory tract infections. Likewise, kidney involvement and acute kidney injury (AKI) were reported in many previous studies. Although a hypovolemic circulation would be the most common reason in patients with AKI, some strong proofs are suggesting a cytokine storm due to immune system exaggeration and inflammation-mediated tubular injury in COVID-19 infections. The inflammatory response in cytokine storm leads to the high release of cytokines mostly including TNFα, IL-1β, IL-6, INFγ, IL-2, IL-7, and endothelial mediators. The main culprits in the AKI and consequent organ failure are resident leukocytes in specific tissues, activated following the cytokine release, and systemic inflammatory response. AKI management and cytokine profile evaluation should be highly emphasized in patients with COVID-19 to prevent the progression of chronic kidney disease or permanent renal failure. Treatment options in COVID-19 regarding no specific drugs should be supportive and based on stabilizing the patients; however, combination therapy with different antiviral have shown promising outcomes. As a result, utilizing the anti-TNFα and anti-IL-1 agents should be noticed if indicated. Additionally, the hematopoietic stem cell transplantation is a curative approach.

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Section: Clinical and Laboratory Findings In Covid-19associated Akimentioning

confidence: 99%

Acute kidney injury due to cytokine storm in patients with COVID-19 infection

2020

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Infectious Diseases Evaluation of the Child With Suspected Hemophagocytic Lymphohistiocytosis

Deza Leon,

Otto,

Danziger-Isakov

et al. 2024

Journal of the Pediatric Infectious Diseases Society

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Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive and maladaptive inflammation. Classic clinical and laboratory features associated with the diagnosis of HLH, including fever, cytopenias, hyperferritinemia and splenomegaly, are not specific to HLH and can be caused by infections. Fulfillment of these clinical and laboratory criteria alone are not sufficient to diagnose HLH or initiate HLH-directed therapies. In this manuscript, we review the pathogenesis of HLH and HLH-like syndromes associated with infection. We offer a paradigm for evaluating patients with suspected HLH to identify key exposures, diagnose and treat infection before initiation of immunosuppression.

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CD8+ T Cell Biology in Cytokine Storm Syndromes

Cited by 2 publications

References 144 publications

Acute kidney injury due to cytokine storm in patients with COVID-19 infection

Acute kidney injury due to cytokine storm in patients with COVID-19 infection

Infectious Diseases Evaluation of the Child With Suspected Hemophagocytic Lymphohistiocytosis

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