CD8 T‐cell regulation by T regulatory cells and the programmed cell death protein 1 pathway

Penaloza-MacMaster, Pablo

doi:10.1111/imm.12739

Cited by 14 publications

(11 citation statements)

References 98 publications

(211 reference statements)

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“…Interestingly, we observed an increased frequency of T regs in the BM of REL patients compared with CR. The T reg accumulation has been linked to T-cell exhaustion in recent studies on chronic viral infections 33 and on relapsed/refractory lymphoma patients 34 . However, the phenotypic portrait of exhausted T cells appears more complex and driven by several IRs 16 , 35 .…”

Section: Discussionmentioning

confidence: 99%

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

et al. 2019

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The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of Inhibitory Receptors (IR; PD-1/CTLA-4/TIM-3/LAG-3/2B4/KLRG1/GITR) on T cells infiltrating the bone marrow (BM) of 32 AML patients relapsing (median 251 days) or maintaining complete remission (CR; median 1 year) after HSCT. A higher proportion of early-differentiated Memory Stem (TSCM) and Central Memory BM-T cells express multiple IR in relapsing patients than in CR patients. Exhausted BM-T cells at relapse display a restricted TCR repertoire, impaired effector functions and leukemia-reactive specificities. In 57 patients, early detection of severely exhausted (PD-1+Eomes+T-bet−) BM-TSCM predicts relapse. Accordingly, leukemia-specific T cells in patients prone to relapse display exhaustion markers, absent in patients maintaining long-term CR. These results highlight a wide, though reversible, immunological dysfunction in the BM of AML patients relapsing after HSCT and suggest new therapeutic opportunities for the disease.

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Section: Discussionmentioning

confidence: 99%

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

et al. 2019

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“…The phenomenon of cell death is intrinsically linked to the cellular life cycle and aging, and it occurs as a homeostatic mechanism under both physiological and pathological conditions (274)(275)(276)(277)(278)(279). Cells in general may die by two distinct mechanisms, namely, accidental cell death and regulated cell death (RCD) (274).…”

Section: The Role Of Cell Death In Homeostasis and The Control Of Thementioning

confidence: 99%

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

Quaresma

2019

Clin Microbiol Rev

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SUMMARY The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together constitute what is designated skin-associated lymphoid tissue (SALT). In this review, I extensively discuss the organization of SALT and the mechanisms involved in its responses to infectious diseases of the skin and mucosa. The nature of these SALT responses, and the cellular mediators involved, often determines the clinical course of such infections. I list and describe the components of innate immunity, such as the roles of the keratinocyte barrier and of inflammatory and natural killer cells. I also examine the mechanisms involved in adaptive immune responses, with emphasis on new cytokine profiles, and the role of cell death phenomena in host-pathogen interactions and control of the immune responses to infectious agents. Finally, I highlight the importance of studying SALT in order to better understand host-pathogen relationships involving the skin and detail future directions in the immunological investigation of this organ, especially in light of recent findings regarding the skin immune system.

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“…RANTES is produced by the decidua [28] and the placenta [47]. Trophoblast produces MIP-1α and RANTES, CCL3 [54,99].…”

Section: Differentiation Of Cd8 + T Lymphocytesmentioning

confidence: 99%

The Role of Subpopulations of Cd8+ T Lymphocytes in the Development of Pregnancy

Степанова¹,

Bazhenov²,

Khokhlova³

et al. 2018

Med. immunol.

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At the present time, a broad spectrum of CD8+ T lymphocyte subsets is revealed, including naïve cells, memory cells and regulatory subpopulations. Along with cells with high cytolytic activity, some subsets with marked regulatory activity were found there. Each subpopulation is characterized by a set of produced mediators, surface and intracellular markers allowing to suggest their differential in vivo functional activity. The present review article proposes a classification of CD8+ Т cells which takes into account their morphological and functional features. According to conventional view, the CD8+ Т lymphocytes is a cell population exhibiting high cytotoxic ability which is of critical significance in pregnancy, under the conditions of semi-allogenic fetal cell invasion into the endometrium. The fraction of CD8+ T cells is rather high in decidual structures. The review discusses the known mechanisms of differentiation regulation, selective migration and activity of CD8+ T cells in decidual membrane and placenta in the course of pregnancy. Perforine and granzyme are the main cytotoxicity factors of CD8+ Т cells. IL-2, IL-5, IL-13, IFNγ, IL-17, TGF-β and IL-10 cytokines are considered regulatory mediators of CD8+ cells. To induce the effector properties of CD8+ T cells, an antigenic stimulation is required, which is provided by interactions between the CD8+ Т cells and activated CD4+ Т cells or dendritic cells, cytokine effects. Specific differentiation of the CD8+ T cells is determined by differences in microenvironvent. In the course of pregnancy, accumulation of CD8+ Т cells is observed in decidual membrane, but their phenotype and functional properties differ from CD8+ Т cells in peripheral blood. At present time, the mechanisms of selective CD8+ T cell migration to decidual membrane are studied. These events are suggested to be mediated by means of CXCR3 and CCR5 chemokine receptors, IL-6 and IL-15 cytokines. The features of CD8+ Т cell activities, and production of some cytokines, e.g., CSF2, IFNγ, IL-1β, IL-2, IL-6, IL-8,IL-10, IL-12 and TNFα in decidual membrane and is of critical significance for effective invasion of trophoblast cells. In turn, the trophoblast and placental cells promote development of regulatory CD8+ Т lymphocytes in decidual membrane, being able to induce CD8+ T cell apoptosis in decidual membrane. Hence, interaction between the maternal CD8+ T cells and trophoblast in the area of uterine-placental contact is an important link during development of immunological tolerance in the maternal/fetal system.

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CD8 T‐cell regulation by T regulatory cells and the programmed cell death protein 1 pathway

Cited by 14 publications

References 98 publications

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

The Role of Subpopulations of Cd8+ T Lymphocytes in the Development of Pregnancy

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