CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study

Zhao, Bing; Han, Hui; Zhen, Junhui; Yang, Xiaowei; Shang, Jin; Xu, Liang; Wang, Rong

doi:10.7717/peerj.5400

Cited by 10 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They went on to use ROC curves to assess the ability of CD80 to discriminate MCD ( n = 37) from FSGS ( n = 27), and found an AUC of 0.925, sensitivity 81.1%, and specificity 94.4% (22). Several other research teams have found similar differences in urine CD80 when comparing relapsed MCD, remission MCD, and FSGS (26–29).…”

Section: Urine and Serum Biomarkersmentioning

confidence: 60%

The Search for Biomarkers to Aid in Diagnosis, Differentiation, and Prognosis of Childhood Idiopathic Nephrotic Syndrome

Stone¹,

Magella²,

Bennett³

2019

Front. Pediatr.

View full text Add to dashboard Cite

Identification of genes associated with childhood-onset nephrotic syndrome has significantly advanced our understanding of the pathogenesis of this complex disease over the past two decades, however the precise etiology in many cases remains unclear. At this time, we still rely on invasive kidney biopsy to determine the underlying cause of nephrotic syndrome in adults. In children, response to steroid therapy has been shown to be the best indicator of prognosis, and therefore all children are treated initially with corticosteroids. Because this strategy exposes a large number of children to the toxicities of steroids without providing any benefit, many researchers have sought to find a marker that could predict a patient's response to steroids at the time of diagnosis. Additionally, the identification of such a marker could provide prognostic information about a patient's response to medications, progression to end stage renal disease, and risk of disease recurrence following transplantation. Major advances have been made in understanding how genetic biomarkers can be used to predict a patient's response to therapies and disease course, especially after transplantation. Research attempting to identify urine- and serum-based biomarkers which could be used for the diagnosis, differentiation, and prognosis of nephrotic syndrome has become an area of emphasis. In this review, we explore the most exciting biomarkers and their potential clinical applications.

show abstract

Section: Urine and Serum Biomarkersmentioning

confidence: 60%

The Search for Biomarkers to Aid in Diagnosis, Differentiation, and Prognosis of Childhood Idiopathic Nephrotic Syndrome

Stone¹,

Magella²,

Bennett³

2019

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…The CD80 protein on macrophages can activate T lymphocytes and play an important role in the adaptive immune response 35 . Previously, expression of CD80 was found to be stronger in M1‐like macrophages than in M2‐like macrophages 18,35 .…”

Section: Resultsmentioning

confidence: 99%

“…The CD80 protein on macrophages can activate T lymphocytes and play an important role in the adaptive immune response. 35 Previously, expression of CD80 was found to be stronger in M1-like macrophages than in M2-like macrophages. 18,35 To differentiate the M1-like macrophages in vivo among the other macrophage populations, expression of CD80 was studied (Figure 2A(2)).…”

Section: Identification Of M1 M2 Macrophages and Satellite Cells mentioning

confidence: 94%

Hybridization‐chain‐reaction is a relevant method for in situ detection of M2d‐like macrophages in a mini‐pig model

Nikovics¹,

Morin

Riccobono³

et al. 2020

FASEB j.

View full text Add to dashboard Cite

Macrophages are the ultimate actors to trigger and coordinate an efficient repair of damaged tissue. 1-6 When repair is not coordinated, regeneration fails and fibrosis can take place. Investigation of macrophage subpopulations is essential in establishing new diagnostics for multiple diseases 6-12 as well as therapeutic strategies for tissue repair. Macrophages are a heterogeneous population of cells that acquire their functional specialization in response to microenvironmental alterations. Two major populations, M1 and M2, including four M2 subpopulations (M2a, M2b, M2c, and M2d) of macrophages have been identified and investigated. 2,4,5,10,13-15 Each macrophage subpopulation expresses a specific panel of cytokines and is involved in a distinct function (Figure 1). Huge progress has been made on the characterization of macrophages

show abstract

“…More precisely, we detected in RPTECs MHC Class II molecules, assessed in our research by HAL-DR, and co-stimulatory molecules, evaluated in our study by CD80. Interestingly, co-stimulatory molecules may serve as diagnostic and prognostic markers in various kidney diseases, indicating a possible role of T-cells in their pathogenesis [ 35 ]. Cell-adhesion molecules have been studied in nephrology, mainly in the context of atherosclerosis that frequently accompanies chronic kidney disease [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

A Role for Human Renal Tubular Epithelial Cells in Direct Allo-Recognition by CD4+ T-Cells and the Effect of Ischemia-Reperfusion

Eleftheriadis

Pissas

Crespo

et al. 2021

IJMS

View full text Add to dashboard Cite

Direct allorecognition is the earliest and most potent immune response against a kidney allograft. Currently, it is thought that passenger donor professional antigen-presenting cells (APCs) are responsible. Further, many studies support that graft ischemia-reperfusion injury increases the probability of acute rejection. We evaluated the possible role of primary human proximal renal tubular epithelial cells (RPTECs) in direct allorecognition by CD4+ T-cells and the effect of anoxia-reoxygenation. In cell culture, we detected that RPTECs express all the required molecules for CD4+ T-cell activation (HLA-DR, CD80, and ICAM-1). Anoxia-reoxygenation decreased HLA-DR and CD80 but increased ICAM-1. Following this, RPTECs were co-cultured with alloreactive CD4+ T-cells. In T-cells, zeta chain phosphorylation and c-Myc increased, indicating activation of T-cell receptor and co-stimulation signal transduction pathways, respectively. T-cell proliferation assessed with bromodeoxyuridine assay and with the marker Ki-67 increased. Previous culture of RPTECs under anoxia raised all the above parameters in T-cells. FOXP3 remained unaffected in all cases, signifying that proliferating T-cells were not differentiated towards a regulatory phenotype. Our results support that direct allorecognition may be mediated by RPTECs even in the absence of donor-derived professional APCs. Also, ischemia-reperfusion injury of the graft may enhance the above capacity of RPTECs, increasing the possibility of acute rejection.

show abstract

CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study

Cited by 10 publications

References 36 publications

The Search for Biomarkers to Aid in Diagnosis, Differentiation, and Prognosis of Childhood Idiopathic Nephrotic Syndrome

The Search for Biomarkers to Aid in Diagnosis, Differentiation, and Prognosis of Childhood Idiopathic Nephrotic Syndrome

Hybridization‐chain‐reaction is a relevant method for in situ detection of M2d‐like macrophages in a mini‐pig model

A Role for Human Renal Tubular Epithelial Cells in Direct Allo-Recognition by CD4+ T-Cells and the Effect of Ischemia-Reperfusion

Contact Info

Product

Resources

About