2017
DOI: 10.3389/fimmu.2017.01216
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CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases

Abstract: Endothelial cells lining new blood vessels that develop during inflammatory disorders or cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent data show that these endothelial cells in cancer tissues and inflamed tissues of lupus patients overexpress CD95L, the biological role of which is a subject of debate. The receptor CD95 (also named Fas or apoptosis antigen 1) belongs to the tumor necrosis factor (TNF) receptor superfamily. Its cognate ligand, CD95L, is implicated … Show more

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Cited by 70 publications
(61 citation statements)
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References 118 publications
(161 reference statements)
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“…Studies have shown that Fas/FasL signaling in B cells contributes to cellular processes such as maturation, proliferation and immunoglobulin production ( 11 ). Fas is highly expressed in activated B cells ( 31 ), the dysfunction B cell-specific Fas is associated with the onset of autoimmunity ( 32 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Studies have shown that Fas/FasL signaling in B cells contributes to cellular processes such as maturation, proliferation and immunoglobulin production ( 11 ). Fas is highly expressed in activated B cells ( 31 ), the dysfunction B cell-specific Fas is associated with the onset of autoimmunity ( 32 ).…”
Section: Discussionmentioning
confidence: 99%
“…The Fas/FasL complex play an important role in immune homeostasis by inducing cell apoptosis. In addition, recent data showed that Fas/FasL system also act as an effective chemoattractant for neutrophils, suggesting a potential pro-inflammatory function of these molecules ( 11 ). The Fas/FasL system contains both membrane-bound versions of (mFas and mFasL) and soluble versions (sFas and sFasL), sFas is mainly expressed on epithelial cells and activated lymphocytes, it regulates T cell homeostasis by mediates proliferation and death of T lymphocytes ( 12 ).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, we evaluated the expression of antigen presenting cells (APC) co-stimulatory molecules (CD80, CD86, CD40, CD95) and co-inhibitory molecules (CD273, CD274, B7H4, CD200, Galectin-9). Both maternal and fetal cell populations did not express co-stimulatory markers, with the exception of CD95 (stimulatory) [51][52][53] that was expressed by all three populations. On the other hand, co-inhibitory markers such as CD273 (PD-L2), CD274 (PD-L1), and Galectin-9 were expressed by all three populations, where the latter was highly expressed (>70%), (Figure 1).…”
Section: Immunophenotype Of Maternal and Fetal Cellsmentioning
confidence: 91%
“…FAS signalling also induced various functions in addition to cell death [155][156][157][158] . The lymphadenopathy that is prominent in mouse and human 159 mutants of the FAS pathway indicates that a main function of this pathway is to regulate the immune system, classically through the control of lymphocyte death although other mechanisms have been proposed 158,160 .…”
Section: [H1] Fas-based Cytotoxicity: Mid-1990smentioning
confidence: 99%