CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis

Cantor, Joseph M.

doi:10.1016/j.jneuroim.2014.06.015

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…High levels of CD98 expression in cancer cells have been widely reported as a promising biomarker of various cancers and are correlated with a poor prognosis ( 58 – 60 ). In addition, CD98 participates in autoimmune diseases such as type I diabetes and encephalomyelitis by promoting the clonal expansion of lymphocytes ( 44 , 45 , 61 ). The blockade of CD98 in T cells can attenuate T cell migration, thereby contributing to the acceptance of cardiac allografts ( 62 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

Zhang

Zhou

Chen

et al. 2022

mBio

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Section: Discussionmentioning

confidence: 99%

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

Zhang

Zhou

Chen

et al. 2022

mBio

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“…2A and B). Rapid proliferation of other cell types such as T cells 21 and B cells 12 is dependent on CD98hc. We show in vivo that after 8 weeks of HFD, CD98hc −/− VSMC display significantly reduced proliferation and increased apoptosis (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…CD98 is a transmembrane protein made up of a heavy chain (CD98hc) and one of several light chains that is involved in biological events and diseases that require proliferative and migratory processes, including cancer 10 and several autoimmune diseases 11, 12 . The protein has dual functions, including transporting large, neutral amino acids via its interaction with various light chains, and mediating integrin signaling via its cytoplasmic tail, specifically β1- or β3-integrins 1314, 15 .…”

Section: Introductionmentioning

confidence: 99%

CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis

et al. 2017

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Background and aims Vascular smooth muscle cells (VSMC) migrate and proliferate to form a stabilizing fibrous cap that encapsulates atherosclerotic plaques. CD98 is a transmembrane protein made of two subunits, CD98 heavy chain (CD98hc) and one of six light chains, and is known to be involved in cell proliferation and survival. Because the influence of CD98hc on atherosclerosis development is unknown, our aim was to determine if CD98hc expressed on VSMC plays a role in shaping the morphology of atherosclerotic plaques by regulating VSMC function. Methods In addition to determining the role of CD98hc in VSMC proliferation and apoptosis, we utilized mice with SMC-specific deletion of CD98hc (CD98hcfl/flSM22αCre+) to determine the effects of CD98hc deficiency on VSMC function in atherosclerotic plaque. Results After culturing for 5 days in vitro, CD98hc−/− VSMC displayed dramatically reduced cell counts, reduced proliferation, as well as reduced migration compared to control VSMC. Analysis of aortic VSCM after 8 weeks of HFD showed a reduction in CD98hc−/− VSMC proliferation as well as increased apoptosis compared to controls. A long-term atherosclerosis study using SMC-CD98hc−/−/ldlr−/− mice was performed. Although total plaque area was unchanged, CD98hc−/− mice showed reduced presence of VSMC within the plaque (2.1±0.4% vs. 4.3±0.4% SM22α-positive area per plaque area, p<0.05), decreased collagen content, as well as increased necrotic core area (25.8±1.9% vs. 10.9±1.6%, p<0.05) compared to control ldlr−/− mice. Conclusions We conclude that CD98hc is required for VSMC proliferation, and that its deficiency leads to significantly reduced presence of VSMC in the neointima. Thus, CD98hc expression in VSMC contributes to the formation of plaques that are morphologically more stable, and thereby protects against atherothrombosis.

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“…CD98 is a transmembrane protein made up of a heavy chain (CD98hc) and one of several light chains that is involved in biological events and diseases that require proliferative and migratory processes, including cancer 10 and several autoimmune diseases 11,12 . The protein has dual functions, including transporting large, neutral amino acids via its interaction with various light chains, and mediating integrin signaling via its cytoplasmic tail, specifically β1-or β3-integrins 1314, 15 .…”

Section: Introductionmentioning

confidence: 99%

CD98 Regulates Vascular Smooth Muscle Cell Proliferation in Atherosclerosis

Baumer¹,

McCurdy²,

Alcalá³

et al. 2017

Journal of Vascular Surgery

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Background and aims-Vascular smooth muscle cells (VSMC) migrate and proliferate to form a stabilizing fibrous cap that encapsulates atherosclerotic plaques. CD98 is a transmembrane protein made of two subunits, CD98 heavy chain (CD98hc) and one of six light chains, and is known to be involved in cell proliferation and survival. Because the influence of CD98hc on atherosclerosis development is unknown, our aim was to determine if CD98hc expressed on VSMC plays a role in shaping the morphology of atherosclerotic plaques by regulating VSMC function.

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CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis

Cited by 5 publications

References 29 publications

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis

CD98 Regulates Vascular Smooth Muscle Cell Proliferation in Atherosclerosis

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