CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells

Lee, Eun Jung; Lee, Hyun Gyu; Park, Shin Young; Choi, Eun Young; Park, Seong Hoe

doi:10.1038/emm.2003.57

Cited by 19 publications

(16 citation statements)

References 28 publications

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“…Its expression is strong in the Ewing sarcoma/primitive neuroectodermal tumor (PNET) family [3], but it can also occur in many other mesenchymal [4,5], hematopoietic [6,7] and even some epithelial tumors [2,8,9]. CD99 is involved in differentiation of primitive neuroectodermal cells [10] and apoptosis of T cells [11], but its role in epithelial tissues and neoplasms originating from them remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

CD99 correlates with low cyclin D1, high topoisomerase 2 status and triple negative molecular phenotype but is prognostically irrelevant in breast carcinoma

Czapiewski¹,

Wełnicka-Jaśkiewicz²,

Seroczyńska³

et al. 2015

pjp

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CD99 is a protein initially described in the Ewing sarcoma family of tumors, but growing evidence has shown its expression in other tumors of mesenchymal, hematopoietic and even epithelial origin. Some articles report CD99 in metaplastic carcinoma of the breast, a subtype of breast carcinoma (BC) with pronounced epithelial to mesenchymal (EMT) phenotype. Our aim was to analyse the potential relationship between CD99 and selected EMT (vimentin, E-cadherin, Twist) and proliferation markers (Ki-67, c-myc, cyclin D1, topoisomerase 2α), molecular subtypes of BC, as well as overall survival (OS) and progression-free survival (PFS). In a group of 122 cases CD99 membrane expression was seen in 14 (11.5%) cases: strong in 11 (9%) and moderate in 3 (2.5%). Expression of CD99 correlated with low cyclin D1 index, high level of topoisomerase 2α expression and lack of progesterone receptor (PR) but not with EMT characteristics. Additionally, strong expression of CD99 correlated with triple negative molecular BC phenotype. CD99 was prognostically irrelevant for OS and PFS. CD99 correlates with selected proliferative markers and low ER/PR receptor status but not with patients' outcome in BC. Further studies are required to explain precisely its role in molecular pathogenesis of BC.

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Section: Introductionmentioning

confidence: 99%

CD99 correlates with low cyclin D1, high topoisomerase 2 status and triple negative molecular phenotype but is prognostically irrelevant in breast carcinoma

Czapiewski¹,

Wełnicka-Jaśkiewicz²,

Seroczyńska³

et al. 2015

pjp

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“…Several factors play a role in the regulation of neurogenesis, and in particular, neurotrophic factors are known to be critical for the survival of new-born cells during their development in vivo and in culture (Palmer et al, 1997). Among the factors that are involved in neural and glial differentiation (Aberg et al, 2000;Lee et al, 2003;Kim et al, 2004), brain-derived neurotrophic factor (BDNF) is interesting, because it has been shown to promote the differentiation and survival of progenitor cells in the adult brain (Zigova et al, 1998), and in cultured cells (Vicario-Abejon et al, 1995;Palmer et al, 1997). In addition, singing behavior has also been reported to increase the expression of BDNF, and this was also found to be correlated with the extent of new Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus neuron survival (Li et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Lee

Kim²,

Kim³

et al. 2006

Exp Mol Med

112

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New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not clear whether chronic stress affects neurogenesis. To determine whether chronic mild stress (CMS) influences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or proliferation of new-born cells, respectively. In addition, we measured brain-derived neurotrophic factor (BDNF) mRNA in the granule cell layer (GCL) of the hippocampus, because BDNF is known to play an important role in the survival of new-born cells. CMS significantly decreased the survival of newborn cells in the GCL, but did not influence the proliferation or differentiation of new-born cells. CMS did not affect the proliferation and survival of new-born cells in the hilus. In addition, CMS did not change BDNF mRNA levels in the GCL. These results demonstrate that CMS reduces the survival of new-born cells but not of their proliferation, suggesting that repeated mild stress could influence a part of neurogenesis, but not the whole part of neurogenesis. These results raise the possibility that the survival of new-born cells may be suppressed in the presence of normal BDNF mRNA levels in GCL.

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“…For detection of the 2 CD99 isoforms that differ by their intracytoplasmic tail, 2 sets of previously published oligonucleotides 38 were used, and real-time polymerase chain reaction (PCR) was carried out using the Light Cycler 2.0 instrument and the software version 4.0 (Roche Applied Science, Mannheim, Germany). The 20-L reaction mixture contained 4 L of 5 ϫ Master Mix (Roche Applied Science), 0.5 M of each primer, and 1 L cDNA sample.…”

Section: Rna Extraction and Quantitative Real-time Polymerase Chain Rmentioning

confidence: 99%

“…Differential expression of these 2 forms is associated with distinct behaviors for phenomena such as CD99-induced cell adhesion or T-cell death. 36,37 The short CD99 isoform is a negative regulator of neural differentiation 38 and is also involved in the induction of motility and invasiveness of human breast cancer cells. 39 Although the expression of CD99 on hematopoietic cells, especially at the early stage of B-cell, T-cell, or neutrophil differentiation has been reported, 40 little is known about CD99 expression and function in the hematopoietic progenitor compartment.…”

Section: Introductionmentioning

confidence: 99%

CD99 expressed on human mobilized peripheral blood CD34+ cells is involved in transendothelial migration

Imbert

Belaaloui

Bardin

et al. 2006

Blood

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CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells

Cited by 19 publications

References 28 publications

CD99 correlates with low cyclin D1, high topoisomerase 2 status and triple negative molecular phenotype but is prognostically irrelevant in breast carcinoma

CD99 correlates with low cyclin D1, high topoisomerase 2 status and triple negative molecular phenotype but is prognostically irrelevant in breast carcinoma

Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

CD99 expressed on human mobilized peripheral blood CD34+ cells is involved in transendothelial migration

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