What is known on this topic? The Mississippi Delta has high rates of chronic disease and is known for its poor health outcomes and health disparities. Medication therapy management (MTM) improves the safe and effective use of medications, and ensuring appropriate medication use can improve clinical outcomes related to cardiovascular disease (CVD). What does this research add to the literature? Pharmacists met face-to-face in federally qualified health centers with patients who had a diagnosis of diabetes, hypertension, and/or dyslipidemia to provide MTM. Patients experienced mean reductions in systolic and diastolic blood pressure, low-density lipoprotein cholesterol, triglycerides, total cholesterol, and hemoglobin A 1c. What are the implications for public health practice? MTM is an effective way to improve CVD outcomes in residents of regions like the Mississippi Delta that have high rates of poverty, health disparities, and poor health outcomes.