2024
DOI: 10.62347/wsef7878
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CDCA8, a mitosis-related gene, as a prospective pan-cancer biomarker: implications for survival prognosis and oncogenic immunology

Hanjie Hu

Abstract: Background: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as a prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers. This study analyzed the diagnostic/prognostic potential and clinical implications of CDCA8 across diverse cancers. Methods: Bioinformatics and molecular experiments. Results: Analyzing TCGA data via TIMER2 and GEPIA2 databases revealed significant up-regulation of CDCA8 in 23 cancer type… Show more

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Cited by 6 publications
(1 citation statement)
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“…These technologies have led to the accumulation of a vast amount of data, accessible through public database platforms like Gene Expression Omnibus (GEO) [ 9 ] and The Cancer Genome Atlas (TCGA) [ 10 , 11 ]. By leveraging the wealth of information in GEO and TCGA, scientists can uncover novel molecular signatures and candidate biomarkers that may have diagnostic, prognostic, or therapeutic implications in the fight against cancer [ 12 ]. The integration of GEO data with other experimental approaches enables a deeper understanding of cancer biology and aids in the early detection and treatment of cancer.…”
Section: Introductionmentioning
confidence: 99%
“…These technologies have led to the accumulation of a vast amount of data, accessible through public database platforms like Gene Expression Omnibus (GEO) [ 9 ] and The Cancer Genome Atlas (TCGA) [ 10 , 11 ]. By leveraging the wealth of information in GEO and TCGA, scientists can uncover novel molecular signatures and candidate biomarkers that may have diagnostic, prognostic, or therapeutic implications in the fight against cancer [ 12 ]. The integration of GEO data with other experimental approaches enables a deeper understanding of cancer biology and aids in the early detection and treatment of cancer.…”
Section: Introductionmentioning
confidence: 99%