CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (l-glutamic acid)/CDDP complexes

Yong, Da-Wei; Luo, Yu; Du, Fu‐Sheng; Huang, Jin; Lü, Wei; Dai, Zhao-yun; Yu, Jiahui; Liu, Shiyuan

doi:10.1016/j.colsurfb.2012.12.046

Cited by 20 publications

(15 citation statements)

References 19 publications

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“…In vitro cytotoxicity studies using F98 glioma cells showed that CDDP-BPN exhibited lower potency compared to CDDP solution which is most likely due to slow release of CDDP from CDDP-BPN as observed in case of in vitro release kinetics of CDDP-BPN. Several other types of polymer- and lipid-based nanoparticles containing CDDP have also shown lower in vitro potency against F98 glioma and other cancer cells compared to carrier-free CDDP solution[48–51]. We anticipate that combined with weekly MRgFUS, these CDDP-BPN could provide stable local drug concentrations with reduced systemic and local toxicities.…”

Section: Discussionmentioning

confidence: 99%

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

Timbie

Afzal

Date

et al. 2017

Journal of Controlled Release

105

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Systemically administered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high interstitial pressure generate a “blood-tumor barrier” (BTB), which inhibits drug delivery and distribution. Meanwhile, beyond the contrast MRI-enhancing edge of the tumor, invasive cancer cells are protected by the intact blood-brain barrier (BBB). Here, we tested whether brain-penetrating nanoparticles (BPN) that possess dense surface coatings of polyethylene glycol (PEG) and are loaded with cisplatin (CDDP) could be delivered across both the blood-tumor and blood-brain barriers with MR image-guided focused ultrasound (MRgFUS), and whether this treatment could control glioma growth and invasiveness. To this end, we first established that MRgFUS is capable of significantly enhancing the delivery of ~60 nm fluorescent tracer BPN across the blood-tumor barrier in both the 9L (6-fold improvement) gliosarcoma and invasive F98 (28-fold improvement) glioma models. Importantly, BPN delivery across the intact BBB, just beyond the tumor edge, was also markedly increased in both tumor models. We then showed that a CDDP loaded BPN formulation (CDDP-BPN), composed of a blend of polyaspartic acid (PAA) and heavily PEGylated polyaspartic acid (PAA-PEG), was highly stable, provided extended drug release, and was effective against F98 cells in vitro. These CDDP-BPN were delivered from the systemic circulation into orthotopic F98 gliomas using MRgFUS, where they elicited a significant reduction in tumor invasiveness and growth, as well as improved animal survival. We conclude that this therapy may offer a powerful new approach for the treatment invasive gliomas, particularly for preventing and controlling recurrence.

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Section: Discussionmentioning

confidence: 99%

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

Timbie

Afzal

Date

et al. 2017

Journal of Controlled Release

105

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“…[106] Liu and coworkers investigated a b-CD-centered seven-arm poly(lglutamic acid) with drug attachment, namely cisdichlorodiamineplatinum(II). [107] Theformation of complexes with adamantyl-functionalized PEG led to supramolecular miktoarm star polymers that undergo assembly into drugreleasing micelles with cmc values ranging from 3.2 to 7.9 mg L À1 and particle sizes from 100 to 135 nm depending on the number of poly(l-glutamic acid) arms.M icelle formation of ab rush polymer was also described by Jiang and co-workers (Figure 6a). [104] Here,P VP was formed together with b-CD-containing monomers,a nd adamantyl end functionalized PCL was grafted in asupramolecular way.…”

Section: Micelles/core-shell Particlesmentioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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Dynamic and adaptive materials are powerful constructs in macromolecular and polymer chemistry with a wide array of applications in drug delivery, bioactive systems, and self‐healing materials. Very often, dynamic materials are based on carefully tailored cyclodextrin host–guest interactions. The precise incorporation of these host and guest moieties into macromolecular building blocks allows the formation of complex macromolecular structures with predefined functions. Thus, dynamic materials with extraordinary adaptive property profiles—responsive to thermal, chemical, and photonic fields—become accessible. This Review explores the hierarchical formation of dynamic materials and complex macromolecular structures from the molecular via the macromolecular to the colloidal and macroscopic level, with a specific emphasis on the functionality and responsiveness of the assemblies, specifically in biological contexts.

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“…involving appendage of seven poly(L-glutamic acid) chains on the primary face of β-cyclodextrin (Yong et al, 2013). This system has been used to develop nanoparticles (micelles) for the targeted delivery of the anti-cancer drug cisdichlorodiammine platinum (II) (CDDP).…”

Section: Applications Of Single-isomer Anionic Cdsmentioning

confidence: 99%

“…Thus the single-isomer derivative 16 was derived by the reaction of the star-shaped poly(γ-benzyl-L-glutamate) with octakis(6-amino-6-deoxy)-γ-CD followed by hydrolysis of the benzyl ester (Yong et al, 2013) (Scheme 8). The metal binding ability of 16 is analyzed in 5.1.…”

Section: Scheme 7 214 Derivatives With Oligomers /Polymers On Each mentioning

confidence: 99%

Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI

Mavridis

Yannakopoulou

2015

International Journal of Pharmaceutics

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CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (l-glutamic acid)/CDDP complexes

Cited by 20 publications

References 19 publications

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI

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